Over 3 years we performed WGS-based surveillance of S. aureus in the NICU at @childrensphila.bsky.social, sequencing both surveillance and bloodstream infection isolates, to understand how colonization, transmission, and persistence are associated with invasive infection in high-risk neonates.

Thrilled to share this study tracking Staph aureus carriage and transmission across the NICU using genomics! Work done w @pjplanet.bsky.social & @ahmedmicrobes.bsky.social and made possible by @centermicrobialmed.bsky.social. Study co-led by the amazing @qianxuan.bsky.social & Lakshmi Srinivasan!

This study was made possible through an amazing collaboration across the CHOP NICU, CHOP Infectious Disease Diagnostics Lab (IDDL), CHOP Infection Prevention and Control, the Microbial Archive and Cryocollection at CHOP (MicrobialARC), and @centermicrobialmed.bsky.social.

In this study we tracked carriage, transmission, and invasive infection with S. aureus across 33 months in the NICU. Using longitudinal WGS, we identify risk factors for transmission of invasive clones, and show strains that are transmitted more rapidly are more likely to cause invasive disease

Excited to share our work with @pjplanet.bsky.social and @ahmedmicrobes.bsky.social tracking Staph aureus transmission across the NICU using genomics!! This study was co-led by the amazing @qianxuan.bsky.social and Lakshmi Srinivasan, and made possible by the @centermicrobialmed.bsky.social

Our preprint on genomic epidemiology in the NICU! Strains that transmit faster also cause more invasive disease! nam10.safelinks.protection.outlook.com?url=https%3A...