Mustafa Sahin
@sahinm.bsky.social
š¤ 295
š„ 200
š 4
developmental neurobiologist, child neurologist Lab: Sahin-lab.org
reposted by
Mustafa Sahin
Wardiya Afshar-Saber
20 days ago
Itās been a great publishing week for the
@sahinm.bsky.social
ās lab! Kellen Winden and team provide an inādepth overview of the biology, diagnosis, management, and evolving research landscape of
#TSC
. A great resource highlighting advances in this important genetic cause of
#epilepsy
and
#autism
.
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Tuberous sclerosis complex
Nature Reviews Disease Primers - This Primer by Sahin and colleagues summarizes the epidemiology, pathophysiology, diagnosis and treatment of tuberous sclerosis complex.
https://www.nature.com/articles/s41572-026-00688-9.epdf?sharing_token=pN57Rk7mokh4M2uVey_6X9RgN0jAjWel9jnR3ZoTv0NNUOhxDEGUFIcLJI75CwUoq_dB3fdFf3XJafW-HGBUnFazVJsLK-ytkGfAL9ZqEB5NhnIn_L6rKX3LZzQ3aJqREIHcunPDhXWB0fEhTeUZpt3ONVzBrpEfdL1nKxe2gyw%3D
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reposted by
Mustafa Sahin
Wardiya Afshar-Saber
23 days ago
Publication alert! We built an
#opensource
platform for functional phenotyping of hiPSC-derived
#neurons
, combining calcium
#imaging
,
#optogenetic
stimulation,
#automated
acquisition and analysis into an accessible workflow.
@fedegasparoli.bsky.social
@sahinm.bsky.social
@sciwhye23.bsky.social
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An OpenāSource Pipeline for Calcium Imaging and AllāOptical Physiology in Human Stem CellāDerived Neurons
This work introduces an open-source all-optical platform for functional phenotyping of human stem cell-derived neurons. The system integrates optogenetics, calcium imaging, automated acquisition, and...
https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202515887#diseasemodeling
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9
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reposted by
Mustafa Sahin
Susanne Ahmari
11 months ago
š£ļøNon-federal funding alert!!! Aligning Research to Impact Autism (ARIA) has a new RFA to join their IMPACT Network, a clinical-translational research effort to accelerate care for people across the spectrum by enabling rapid therapeutic development. Up to $15 million over 5 years.
bit.ly/3YRYMv3
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Innovative Medicine and Precision Approaches to Clinical Trials (IMPACT) Network - GMMB-Aria: Production
https://bit.ly/3YRYMv3
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Kari Rosbeck making opening remarks at the inspirational TSC Alliance Regional Conference in Boston
11 months ago
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Excited to share a new paper from our lab out this week in Molecular Psychiatry on an mTORopathy, PTEN Hamartoma Tumor Syndrome.
www.nature.com/articles/s41...
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Phenotypic rescue via mTOR inhibition in neuron-specific Pten knockout mice reveals AKT and mTORC1-site specific changes - Molecular Psychiatry
Molecular Psychiatry - Phenotypic rescue via mTOR inhibition in neuron-specific Pten knockout mice reveals AKT and mTORC1-site specific changes
https://www.nature.com/articles/s41380-025-02916-2
about 1 year ago
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Research from the lab of Clifford Woolf at Boston Children's finds that, in a mouse model of type 2 diabetes, immune cells flood into peripheral nerves. This insight could lead to strategies to prevent peripheral neuropathy in diabetes.
www.nature.com/articles/s41...
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Macrophages protect against sensory axon loss in peripheral neuropathy - Nature
A study in a mouse model of obesity and prediabetes demonstrates that recruitment of macrophages to nerves has a protective role in diet-induced peripheral neuropathy.
https://www.nature.com/articles/s41586-024-08535-1
about 1 year ago
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A new review of protein homeostasis in neurodevelopmental disorders led by Dr. Kellen Winden at Boston Children's Hospital and Juan Ruiz who is now attending MD-PhD program at Yale School of Medicine
authors.elsevier.com/a/1kAvF3Q9h2...
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https://authors.elsevier.com/a/1kAvF3Q9h2ISt5
over 1 year ago
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