Why do identical #mitochondrialdysfunction cause different disease outcomes? A Perspective in EXO proposes that clonal lineage mosaicism and cellular history may help explain tissue-specific vulnerability in #mitochondrialdisease. 🔗Read: www.sciexplor.com/exo/articles... #SpatialOmics #Mitochondria

💡Understanding how ferroptosis propagates between cells has emerged as an important frontier in ferroptosis research. 🔗 Read the Alert: www.eurekalert.org/news-release... 📖 Read the Review: www.sciexplor.com/exo/articles... #Ferroptosis #CellDeath #ExtracellularVesicles #EXOBeyondtheCell

🎉 New Perspective published in EXO! 📖 Decoding the Clonal Origins of Mitochondrial Pathology By Prof. Navdeep S. Chandel and Prof. Yogesh Goyal from Northwestern University 🔗Explore lineage-resolved insights into mitochondrial pathology: www.sciexplor.com/exo/articles... #Mitochondria #Metabolism

From mechanism to function: How Drosophila unlocks the secrets of EV biology. This Review maps EV pathways across species & shows how in vivo genetics accelerates functional discovery. Read more: sciexplor.com/exo/articles... #ExtracellularVesicles #Exosomes #Drosophila #Genetics

🎉We are pleased to share the publication of the new Review! 📖Extracellular vesicles in Drosophila and mammals: Conserved mechanisms and emerging functional roles Led by Prof. Norbert Perrimon (Harvard Medical School). Free to read: www.sciexplor.com/exo/articles... #Extracellularvesicles #exosomes

🎙️EXO Chats Ep03 is LIVE! Thousands of secreted factors circulate through our bodies, but many still have no known receptors. Prof. @brentstockwell.bsky.social talks with Prof. Norbert Perrimon & Dr. Myeonghoon Han about decoding #ligand–receptor interactions. 🔗 www.sciexplor.com/exo/podcast/3

Ferroptosis is emerging as a propagative form of cell death, where lipid peroxides, iron, and intercellular signals may drive wave-like death spreading across cell populations. 🔗Read the full review: sciexplor.com/exo/articles... #Ferroptosis #CellDeath #RedoxBiology #LipidPeroxidation

Gene programs are the missing link for interpretable virtual cells. This framework maps perturbations to phenotypes & paves the way for patient digital twins. Read more: www.sciexplor.com/exo/articles... #VirtualCell #GenePrograms #SingleCell #Genomics #SpatialOmics #EXOBeyondtheCell

Decoding the secretome remains a major challenge in understanding intercellular communication. This EXO review highlights emerging approaches—from CRISPR screening to AI-driven prediction—for mapping ligand–receptor networks: sciexplor.com/exo/articles... #Secretome #SystemsBiology #SpatialOmics

A cell’s defense system can also become its vulnerability. The perspective from Loretta Dorstyn & Sharad Kumar the “caspase-2 paradox” — how genome surveillance shapes liver polyploidy, homeostasis, and cancer risk: sciexplor.com/exo/articles... #Polyploidy #GenomeStability #CancerResearch

Spatial omics can map millions of cells. But can we analyze them reliably? The real bottleneck isn't data generation—it's computation. New review from Jasmine Plummer's lab tackles the challenge: sciexplor.com/exo/articles... #SpatialOmics #Bioinformatics #SpatialBiology

🎉New Perspective published in EXO We are pleased to share the publication of: Anchoring virtual cells on gene programs: from biological networks to patient digital twins Led by Dr. Jie Liao, Zhejiang University. 🔗Read: www.sciexplor.com/exo/articles... #VirtualCell #Spatialbiology #SingleCell

#EditorInTheSpotlight Michael Snyder, EXO Editorial Board Member Stanford W. Ascherman Professor of Genetics A pioneer of multi-omics and personalized medicine. Developed iPOP for predictive and longitudinal health monitoring. #MultiOmics #PrecisionMedicine #Genomics #SystemsBiology #Proteomics

We have hundreds of secreted proteins. But for many of them, their receptors remain unannotated: a major bottleneck in decoding intercellular communication. A recent review highlights why ligand–receptor #deorphanization remains difficult: www.sciexplor.com/exo/articles... #Spatialbiology #Secretome

💡 Is ferroptosis a spreading death wave rather than a cell-autonomous process? A growing body of evidence suggests that #ferroptosis is not restricted to individual cells—but can propagate across tissues in wave-like patterns. Read the article: www.sciexplor.com/exo/articles... #CellDeath #lysosome

Science: First Hormone Cell Atlas at single-cell resolution Hormonal signaling is widely distributed across human cells. Secretin detected in immune cells; GLP-1 receptors in heart cells. Led by Prof. Sarah Teichmann & HCA consortium. Read: www.science.org/doi/abs/10.1... #SingleCell #HumanCellAtlas

How do cells talk to each other? Researchers from Harvard Medical School lay out a roadmap to identify orphan signaling receptors using synthetic biology, AI, and spatial omics. 📰 www.eurekalert.org/news-release... 🔗 sciexplor.com/exo/articles... #LigandReceptor #Deorphanization #SpatialOmics

🎉New Mini Review on STAMP technology now published in EXO! Title: Democratizing the spatial view: STAMP technology from an analytical perspective By Drs. Poudel S, Dezem FS, Martelotto LG, Plummer JT, Green DR. 🔗Free to read: sciexplor.com/exo/articles... #SpatialBiology #STAMP #Transcriptomics

📢 New Review Published in EXO! Title: Ferroptosis spreading through propagative signals By Drs. Saloni K. Hombalkar, Jyotirekha Das, and Michael Overholtzer from @mskcancercenter.bsky.social 🔗 Open access: sciexplor.com/exo/articles... #Ferroptosis #CellDeath #RedoxBiology

📢New Review Published in EXO! Title: Computational workflows and data infrastructures for spatial omics analysis By Drs. Jasmine Plummer, Mariah Alexander, Yutian Liu, Felipe Segato Dezem, and Hayden Chasteen 🔗Read: www.sciexplor.com/exo/articles... #SpatialOmics

🎙️EXO Chats Podcast – Ep02 is LIVE! Hosted by @brentstockwell.bsky.social , Dr. Kathryn Jacobs shares her journey in lymphatics study, the discovery blocking autophagy traps T cells & breaks immunotherapy, and her future vision of lymphatic modulation. 🔗Listen: youtube.com/watch?v=yvbo... #Lymphatics

🧠 Could neuronal metabolism shape neurodegeneration? A new review from Prof. David Rubinsztein’s team (Cambridge) links the mTORC1–autophagy axis to neurodegenerative diseases. 📄 eurekalert.org/news-release... 🔬 doi.org/10.70401/EXO... #Neuroscience #Autophagy #Neurodegeneration

💡Lymphatic endothelial cells aren’t just passive conduits. They control T cell egress via autophagy & S1P, and can make or break immunotherapy. Read the article by Diede Houbaert, @kathrynjacobss.bsky.social, and @agostinislab.bsky.social 🔗: sciexplor.com/exo/articles... #tumorimmunology #autophagy

#AdvisorInTheSpotlight - Meet Sarah A. Teichmann, EXO Advisory Board Member Co-founder&Co-leader, #HumanCellAtlas Professor, University of Cambridge Pioneering single-cell genomics to map every cell in the body. Her vision: A "Multiscale Human" for precision medicine. #SpatialBiology #Genomics

🤝Call for Dedicated Reviewers-Shape the Future of Spatial Biology Together EXO warmly welcome scholars in #cellbiology, #molecularbiology, #spatialomics, and #biochemistry to participate in the peer review and help maintain high-quality publication. #CallForReviewers #PeerReview #SpatialBiology

🎉Congratulations to Prof. Robert S. Langer, EXO's esteemed editorial board member, on the 2026 Welch Award in Chemistry! His pioneering work in drug delivery, macromolecule release, and tissue engineering has impacted healthcare worldwide. welch1.org/news-reports... #BiomedicalEngineering #Chemistry

🔬Decoding the Secretome: From orphan ligands to inter-organ networks. Harvard University's Norbert Perrimon lab reviews how multi-omics & AI decode the secretome's receptor code in spatial context. 🔗Welcome to Read: sciexplor.com/exo/articles... #Secretome #LigandReceptor #SpatialTranscriptomics

📢 New Mini Review Published! Title: Nutrient-sensing and mTORC1 regulation in neuronal homeostasis: from metabolic signaling to neurodegeneration Led by Prof. David C. Rubinsztein from the University of Cambridge 📖 Welcome to read: sciexplor.com/exo/articles... #Neurodegeneration #mTORC1

We are pleased to announce the publication of the inaugural editorial for EXO – Beyond the Cell, authored by Prof. Brent Stockwell, discoverer of ferroptosis and Founding Editor-in-Chief of EXO. 👉 Click the link to read: lnkd.in/gxtsNzmD #SpatialBiology

🎉 Happy New Year 2026 from EXO – Beyond the Cell 🎉 As we step into the new year, we extend our best wishes to the global scientific community. May 2026 inspire pioneering discoveries, foster meaningful collaborations, and deepen our understanding of life from the cellular level to complex systems.

Merry Christmas! 🎄🎄🎄

🎄 Season’s Greetings from EXO - Beyond the Cell 🎄 As 2025 comes to a close, we warmly wish you a joyful holiday season and a productive New Year. 🎈 We look forward to advancing innovative research and fostering scientific discourse together in 2026. ✨

Call for Papers | EXO – Beyond the Cell 🧬🧬🧬 New open-access journal on cell-environment interactions: spatial organisation, dynamic communication, cross-scale integration. Welcoming: Research | Methods | Reviews | Short reports www.sciexplor.com/exo #SpatialOmics #CellEnvironment #OpenAccess

Exciting News! 🎉🎉🎉 Prof. Livia Schiavinato Eberlin joins the Journal: EXO – Beyond the Cell Editorial Board! A leader in Mass spectrometry and Cancer research, she will guide the journal’s leading research. We’re thrilled to have her on board!

Exciting News! 🎉🎉🎉 Prof. Simon Tavaré joins the Journal: EXO – Beyond the Cell Editorial Board! A leader in Statistics, Bioinformatics, and Computational Biology research, he will guide the journal’s leading research. We’re thrilled to have him on board!

Exciting News! 🎉🎉🎉 Prof. Nicole Strittmatter joins the Journal: EXO – Beyond the Cell Editorial Board! A leader in Spatial metabolomics and Mass spectrometry research, she will guide the journal’s leading research. We’re thrilled to have her on board!

Exciting News! 🎉🎉🎉 Prof. Michael Snyder joins the Journal: EXO – Beyond the Cell Editorial Board! A leader in Transcriptomes research, he will guide the journal’s leading research. We’re thrilled to have him on board!

Exciting News! 🎉🎉🎉 Prof. Alison Simmons joins the Journal: EXO – Beyond the Cell Editorial Board! A leader in Human intestine and Mucosal immunology research, she will guide the journal’s leading research. We’re thrilled to have her on board!

Exciting News! 🎉🎉🎉 Prof. Robert Schwabe joins the Journal: EXO – Beyond the Cell Editorial Board! A leader in Hepatic stellate cells and Hepatocellular carcinoma research, he will guide the journal’s leading research. We’re thrilled to have him on board!

Exciting News! 🎉🎉🎉 Prof. Kelly Lee Rogers joins the Journal: EXO – Beyond the Cell Editorial Board! A leader in Microscopy research, she will guide the journal’s leading research. We’re thrilled to have her on board!

Exciting News! 🎉🎉🎉 Prof. Gabriel Rabinovich @gabyrabi.bsky.social joins the Journal: EXO – Beyond the Cell Editorial Board! A leader in Glycoimmunology and Cancer research, he will guide the journal’s leading research. We’re thrilled to have him on board!

Exciting News! 🎉🎉🎉 Prof. Norbert Perrimon @perrimonlab.bsky.social joins the Journal: EXO – Beyond the Cell Editorial Board! A leader in Inter-organ communication research, he will guide the journal’s leading research. We’re thrilled to have him on board!

Exciting News! 🎉🎉🎉 Prof. Helder Nakaya joins the Journal: EXO – Beyond the Cell Editorial Board! A leader in Precision medicine and Spatial transcriptomics research, he will guide the journal’s leading research. We’re thrilled to have him on board!

Exciting News! 🎉🎉🎉 Prof. Julia Laskin joins the Journal: EXO – Beyond the Cell Editorial Board! A leader in Mass spectrometry imaging research, she will guide the journal’s leading research. We’re thrilled to have her on board!

Exciting News! 🎉🎉🎉 Prof. Robert Langer joins the Journal: EXO – Beyond the Cell Editorial Board! A leader in Drug deliverya and Biomaterials research, he will guide the journal’s leading research. We’re thrilled to have him on board!

Exciting News! 🎉🎉🎉 Prof. Neil Kelleher joins the Journal: EXO – Beyond the Cell Editorial Board! A leader in Top down proteomics and Natural products biosynthesis research, he will guide the journal’s leading research. We’re thrilled to have him on board!

Exciting News! 🎉🎉🎉 Prof. Holger Heyn joins the Journal: EXO – Beyond the Cell Editorial Board! A leader in Single cell genomics and Spatial genomics research, he will guide the journal’s leading research. We’re thrilled to have him on board!

Exciting News! 🎉🎉🎉 Prof. Theodore Alexandrov joins the Journal: EXO – Beyond the Cell Editorial Board! A leader in Spatial metabolomics and Single-cell metabolomics research, he will guide the journal’s leading research. We’re thrilled to have him on board!

Exciting News! 🎉🎉🎉 Prof. Kamyar Hadian joins the Journal: EXO – Beyond the Cell Editorial Board! A leader in Ferroptosis and Ubiquitin signaling research, he will guide the journal’s leading research. We’re thrilled to have him on board!

Exciting News! 🎉🎉🎉 Prof. Isabelle Fournier joins the Journal: EXO – Beyond the Cell Editorial Board! A leader in Mass spectrometry imaging and Proteomics research, she will guide the journal’s leading research. We’re thrilled to have her on board!