Joyce Valadares (@joycevaladares.bsky.social)

Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation - Nature Metabolism Casey et al. explore the basic mechanisms of mitochondrial superoxide production and its impact on interleukin-1β production in LPS-treated macrophages. https://doi.org/10.1038/s42255-025-01224-x