How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller? Excited to share our latest work in @science.org on a new small polymerase. 1/n

New paper from my group in @science.org : "A small polymerase ribozyme that can synthesise itself and its complementary strand" www.science.org/doi/10.1126/... Outstanding work by @edogia.bsky.social

Sounds exciting, right?? PhD positions at KCL & Leeds are available through our new EB4BM: Engineering Biology for Biomedicine doctoral training program! eb4bm.org/project/engi... eb4bm.org/project/stru...

📢2025 RSC Chemical Biology Emerging Investigators collection is now published online. This collection features invited contributions from early career researchers who are making significant contributions to the field of chemical biology. ➡️Read the full collection here: https://rsc.li/cbemi25

New paper online! In a distillation of years of painful lessons we've learnt exploring applications of RNA-cleaving DNAzymes as agents for knockdown in cells, we showcase the troubling variety of ways that false positives & negatives can creep in - and how to avoid them. pubs.rsc.org/en/Content/A...