Measles likely came from cows (via rinderpest) around the 6th century BCE. For 2,500 years, we didn’t evolve superhuman resistance—children just died. Real protection only came in the 1960s, with vaccines. Our superpower isn’t evolving into superhumans. It’s outthinking pathogens.

WOW WOW WOW LOOK AT THIS BEAUTIFUL NEW HUBBLE IMAGE OF NGC 346!!! 🌌

New hardware, who dis? 🤣

Questions for RFK Jr.’s Senate Confirmation: Part II open.substack.com/pub/pauloffi...

Please join us on Wednesday, Jan. 8th at Noon for our first #medicalgrandrounds of 2025! 🍾 We will be joined by Kendall Kling, MD and Teresa Zembower, MD from @nufeinbergmed.bsky.social #northwestern #northwesternmedicine #nmim #infectiousdiseases #pathology

Though "Oral is the New IV" with antibiotics (h/t @bradspellberg.bsky.social), it's not always easy to convince reluctant inpatient clinicians -- especially (in my experience) surgeons, who want to treat "aggressively". Interesting dynamic ... blogs.jwatch.org/hiv-id-obser...

Accounting for approximately 350,000 deaths annually worldwide, cervical cancer is preventable with HPV vaccination and screening. Newer chemotherapy, radiotherapy, and immunotherapy techniques have improved survival #idsky #medsky www.nejm.org/doi/full/10....

Questions for RFK Jr.’s Senate Confirmation: Part I open.substack.com/pub/pauloffi...

🆕🔥Just published 🔥🆕 Updates on the Treatment of Drug-Susceptible and Drug-Resistant Tuberculosis(TB) An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline #idsky #TBsky www.atsjournals.org/doi/full/10....

Big Change in TB treatment recommendations. 6 months of RIPE (also called RHEZ) was once the only treatment in town for susceptible TB. Now there's an all oral FOUR months of: Rifapentine INH PZA Moxifloxacin t.co/8EHiWEhEk8

THIS IS HUGE! Researchers at Stanford Medicine have devised an influenza vaccine that prompts immunity to ALL four major flu subtypes AND shows potential against bird flu, indicating a significant advancement in flu prevention and a potential increase in vaccine efficacy. Let’s talk about that! 🧪🧵⬇️

Trials evaluating the effectiveness of treating Mycobacterium tuberculosis infection among contacts of persons with drug-resistant tuberculosis are lacking. Research findings are summarized in a new Quick Take video. youtu.be/5NoUmRlMxs8 #MedSky #IDSky

A Perspective on Vaccinology #IDSky

WH0 2024 in review: 7 countries ( Brazil, Chad, India, Jordan, Pakistan, Timor-Leste, and Viet Nam) eliminated a neglected tropical disease in 2024, including human African trypanosomiasis, leprosy, lymphatic filariasis, and trachoma. www.who.int/news-room/sp...

The US military is the most vaccinated segment of the population. They achieved 97% COVID vaccine coverage in 2021 and receive special vaccines pre-employment in addition to standard adult vaccines. We should aspire to the same levels of vaccination coverage for children in US not less.

This is discussed in wikiguidelines. It is reasonable to not reset if the valve culture from the explant is negative, and it is reasonable to start over if the culture is positive. But there are no data really either way. See WikiGuidelines answer below.

If you are in medical education OR healthcare leadership, you MUST read this!!! Wow. Just wow. thesheriffofsodium.com/2022/02/04/h...

While US is trying to bring back polio, Sweden is trying to eliminate HPV "Researchers will start screening to find all pre-existing infections that might cause cervical cancer starting in the second half of 2025" goal is to sample entire population and vaccinate. www.euronews.com/health/2024/...

Lest you think polio is ancient history: a polio survivor’s voice on your skyline #IDSky #MedSky

Sadly, it’s a good time to once again share this amazing infographic that we ran at @science.org more than 7 years ago 🧪 #IDsky www.science.org/content/arti...

omg table 1

🔥🔥 NEW 🔥🔥 Year In Review: Top Infectious Diseases Articles From 2024 Our new post, a great collaboration with my friend 🌟 @idstewardship.bsky.social 1️⃣6️⃣⚡️🆔 RCTs 7️⃣Syst Reviews/Meta 3️⃣🌏Guidelines ✨️Wiki_Guidelines #idsky #EMIMCC #medsky #utisky EnJoy Share plz! www.idstewardship.com/year-review-...

On this day in 1981, a landmark paper in NEJM described four patients with evidence of immunodeficiency associated with PJP pneumonia, disseminated CMV, and Kaposi sarcoma. The disease would come to be known as HIV/AIDS. Revisit the paper: nej.md/41iekKD #MedSky #IDSky

Dynamics of Histoplasma fungal load in people living with HIV with disseminated histoplasmosis under treatment with liposomal amphotericin B #IDSky #MedMycoSky #HIVSky www.clinicalmicrobiologyandinfection.com/article/S119...

Diagnosis and management of invasive fungal diseases by next-generation sequencing: are we there yet?: Expert Review of Molecular Diagnostics: Vol 0, No ja www.tandfonline.com/doi/abs/10.1...

Not all hospitalized patients with infections need to be treated with antibiotics against P. aeruginosa! 🆕🔥Systematic review and meta-analysis Effect of empiric antibiotics against Pseudomonas aeruginosa on mortality in hospitalized patients #idsky #medsky #utisky academic.oup.com/jac/advance-...

I’m old enough to remember the catastrophic toll of HIV/AIDS denial by South African President Thabo Mbeki, which led to >300,000 AIDS deaths. I never thought that 20 years later, an HIV/AIDS denialist would be tapped for the helm of health policy in the US. RFK Jr MUST be rejected #WorldAIDSDay

Excellent! Good for patients, crowded hospitals, and costs. Should be widely adopted -- already is internationally. But to quote @bradspellberg.bsky.social further down in the thread, "payor reform need to fund this." Already our hospital system worries about deficits in our analogous program.

@cidjournal.bsky.social #IDSky Check out what I made on this snow day! youtu.be/FI7feUMCxlU

For my inaugural post, Im proud to announce the publication of our Safer@Home care model. This is going to change how medicine is practiced. No need to admit pts "for IV antibiotics" anymore. Or just for IV diuresis in CHF. Or just for EtOH withdrawal. Etc. jamanetwork.com/journals/jam...

Wow, our Nature Primer on Tuberculosis has been accessed 210K times! www.nature.com/articles/nrd...

Don't you just love a good disease primer. Especially for neglected rare diseases we don't see in clinical practice on the daily. This #leprosy primer in nature reviews is great and comes with a snapshot summary that's very digestible. #IDSky #MedSky www.nature.com/articles/s41....

I’ll say it again. Vaccines are LIFESAVING MIRACLES.

#chagas #trypanosoma cruzi #romana sign Ref wwwnc.cdc.gov/eid/article/...

#idboardreview pt works at Texas horse ranch🐎& exposure to 🐇 🐿 🐈 presents w/ mild conjunctivitis & mild periorbital cellulitis, no pain on eye movements. No improvement on antibiotics, antivirals. Bartonella/tularemia neg. #idmedEd #IDTwitter #IDsky #idfellows

Inaugural article in a new section in @cidjournal.bsky.social called “Clinical Dilemmas in Infectious Diseases” led by IDMedEd superstars Daniel Minter and Varun Phadke designed to teach clinical reasoning Rewriting the Script academic.oup.com/cid/advance-... #IDSky

All infectious diseases, public health , epidemiology, science lovers and beyond + Dr Fauci fans must read

Dive into this comprehensive article on Ulcer Node Syndrome! Explore the differential diagnosis & examine 4 unique case studies to sharpen your diagnostic skills. #IDsky #MedSky www.ppidjournal.com/doi10-55636-...

Y’all are going to need some infectious diseases experts #IDSky Starter Packs IDSky 1 go.bsky.app/LnAQjdq IDSky 2 go.bsky.app/JNfSvQT IDSky 3 go.bsky.app/FeogT7o IDSky 4 go.bsky.app/D1zxj4E IDSky 5 go.bsky.app/NgGSPeF IDSky 6 go.bsky.app/22VBL8z #MedSky

#IDsky Today I did a panel discussion at Rush for medical students interested in going into ID. It was so fun to see young folks interested in ID! We need to plant the seeds early. This is a nice article on how to communicate how wonderful our field is 👇 doi.org/10.1093/ofid...

🗣️🗣️🗣️: If you are a leader in ID, stop whatever you are doing RIGHT NOW and read this fabulous article by #GonzaloBearman in @cidjournal.bsky.social #IDSky 🤯🤯🤯🤯🤯🤯 academic.oup.com/cid/article-...