A novel personalised mortality risk prediction tool for HIV-associated cryptococcal meningitis could lead to future treatment stratification trials - less intensive regimens for less unwell patients? Our new manuscript. www.thelancet.com/journals/lan... #IDsky #HIV #GlobalHealth #meningitis #fungal

Very excited to share our new piece of work in the Lancet Global Health @lancetgh.bsky.social – Periskope-CM, a set of personalised risk prediction tools for HIV-associated cryptococcal meningitis mortality: www.thelancet.com/journals/lan... #IDsky #HIV #GlobalHealth #meningitis #fungal 1/8

Fantastic piece of work by @richarddriley.bsky.social and others - this is the next step we need to be taking when we report the performance of clinical prediction models.

New research article in The Lancet Microbe Assessment of MpoxPlex, a high-throughput and multiplexed immunoassay: a diagnostic accuracy study www.thelancet.com/journals/lan... #IDSky #ClinMicro #ViroSky #Mpox #OpenAccess #OA

🆕💫 Analysis of AMBITION RCT Individuals started ART w/in 2 wks before presenting with cryptococcal meningitis, presumably active cryptococcal infection, have higher mortality, whereas those presenting on ART for > =2 wks have a more favorable prognosis #idsky academic.oup.com/cid/advance-...

Interesting to #IDSky & #ClinMicro

Ever wonder about the basis for fear-mongering & conspiracy theories about mRNA vax? Wish you had a place to go when someone cites "proof"? I've got you covered! In my latest @plos.org I buckle up for the waves of anti-vax muck likely to come in 2025. 1/2 absolutelymaybe.plos.org/2024/12/28/g...

Great piece in the Lancet Microbe from colleagues at HTD and RIPL about the vaccinating for dengue in travellers! 👏🏻 www.thelancet.com/journals/lan... Full details of how to go about it all for Uk travellers in the excellent Green Book travelhealthpro.org.uk/media_lib/ml... #IDSky #ViroSky

Potential delivery of some antibiotics too? Clearly there may be some significant issues with volume of fluid to be delivered subcutaneously! #OPAT #IDSky #clinmicro #AMR

Fatal Case of Crimean-Congo Hemorrhagic Fever, Portugal, 2024 #IDSky #EpiSky

Our letter about HLH in murine typhus has just been published in the Journal of Infection! doi.org/10.1016/j.ji.... Many thanks to my co-authors, with a special mention to Sophie Skarbek, Sana Sharrack, and @jamesmeiring.bsky.social for all your efforts 🙏

Hi @mattfrieman.bsky.social - TL;DR - our key conceptual advance is that different blood transcriptional biomarkers discriminate early and late phases of infection as a result of cell-specific epigenetic regulation and have important translational applications for respiratory virus infections:

Check out our paper on RNA biomarkers in COVID-19 MX1 expression occurred early in infection before PCR detection…potential role to stratify treatment #IDSky

Poignant frontline perspective of a #Rwandan physician responding to the recent #marburg outbreak. It is well worth a read. We are are two weeks into the 42 day countdown to declaring the outbreak over🤞🏾. These brave HCPs kept us safe. #medsky #idsky 🧪 www.nejm.org/doi/full/10....

Fantastic session at #Medplus in the @rcphysicians.bsky.social today chairing cases from the Imported Fever Service with Sarah Logan. Thanks a bunch to all our panelists and speakers, you were all brilliant. If you’re at Med+ or joining online and missed it, do watch it back!