Antimicrobial resistance (AMR) is a major threat to human health. Bur it's GROSSLY under reported This study showed 4% of ALL deaths at a major London hospital were actually caused AMR but NONE were on the death certificate as cause of death.

11/ Pragmatic designs allow real-world evaluation of clinical effectiveness, but not implementation processes, which would allow scale-up of the intervention if found to be effective. i.e. is the intervention generalisable? We need more effectiveness-implementation hybrid designs.

1/ Delighted to report the results of the Procalcitonin-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection in the UK (BATCH) trial in @LancetChildAdol authors.elsevier.com/sd/article/S...