UW-Madison Wisconsin National Primate Research Center (@uwmadisonwnprc.bsky.social)

Transient rapamycin treatment avoids unwanted host immune responses toward AAV-delivered anti-HIV antibodies - Nature Communications A gene therapy method using AAV can help deliver HIV-fighting antibodies long-term, but the body often rejects them. Here the authors show that a short course of the drug rapamycin helps prevent host anti-drug antibody responses, showing successful antibody delivery in mice and monkeys. https://www.nature.com/articles/s41467-025-63970-6