UC TB Innovation for Impact Collaboratory
@tb-innovation.bsky.social
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Mission: To improve the diagnosis and treatment of patients with tuberculosis (TB)
đ¨ Satellite session at
#UnionConf2025
! âTransforming TB detection with tongue swab-based molecular testingâ đď¸ Nov 19 | 8â9AM | Copenhagen Beyond sputum: tongue swabs + near-POC molecular tools.
unionconf2025.abstractserver.com/programme/#/...
#TB
#GlobalHealth
#Diagnostics
21 days ago
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Can a smartphone-recorded cough help detect
#TB
? The CODA TB DREAM Challenge shows promise: AI + clinical data reached 73.8% specificity at 80% sensitivity across 7 countries. Read more:
academic.oup.com/ofid/advance...
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Accelerating cough-based algorithms for pulmonary tuberculosis screening: Results from the CODA TB DREAM Challenge
AbstractBackground. Open-access data challenges can accelerate innovation in artificial-intelligence (AI)-based tools. In the Cough Diagnostic Algorithm fo
https://academic.oup.com/ofid/advance-article-abstract/doi/10.1093/ofid/ofaf572/8255785?utm_source=advanceaccess&utm_campaign=ofid&utm_medium=email
24 days ago
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New Lancet study in Philippines, Vietnam, South Africa, Uganda & India: People tested for
#TB
prioritize diagnostics that are ⢠Low-cost ⢠Accurate ⢠Deliver results in 15 minutes Findings show need to align WHO TPPs with patient preferences.
www.thelancet.com/journals/lan...
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Preferences for tuberculosis diagnostic test features among people tested for tuberculosis: a multicountry discrete choice experiment
Individuals accessing tuberculosis services across high-burden settings universally value low to no cost tests, high diagnostic accuracy, and rapid result availability. These findings underscore the n...
https://www.thelancet.com/journals/lanprc/article/PIIS3050-5143(25)00012-3/fulltext
about 1 month ago
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reposted by
UC TB Innovation for Impact Collaboratory
Devan Jaganath, MD MPH
3 months ago
We need new biomarkers to improve TB diagnosis in children. In the COMBO study, we performed a comprehensive plasma proteomic analysis across 4 countries and found several protein signatures that met the WHO target accuracy for a TB screening test:
www.nature.com/articles/s41...
#tbsky
#idsky
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Plasma proteomics for biomarker discovery in childhood tuberculosis - Nature Communications
In this work, through a comprehensive proteomics approach, the authors identified host plasma protein biosignatures that could distinguish tuberculosis (TB) disease in children.
https://www.nature.com/articles/s41467-025-61515-5
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Can digital adherence tools improve
#TB
care at scale? We evaluated 99DOTS in Uganda during national scale-up. High uptake (87%), no harm to outcomes, but equity in access remains key. Read more:
www.medrxiv.org/content/10.1...
#tuberculosis
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Scale-up of 99DOTS for tuberculosis treatment supervision in Uganda: An interrupted time series analysis
Background Digital adherence technologies like 99DOTS are being scaled-up for tuberculosis (TB) treatment despite limited evidence of their effectiveness and concerns about accessibility. We evaluated...
https://www.medrxiv.org/content/10.1101/2024.01.22.24300949v2
3 months ago
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New @cochranecollab reviews: combining TB tests for children and people living with HIV can boost sensitivity and could be beneficial in high burden settings, data for new
#WHO
recommendations Full reviews:
bit.ly/45nlHCz
and
bit.ly/4laK2QH
#TB
#HIV
#ChildHealth
#GlobalHealth
#EndTB
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Parallel use of lowâcomplexity automated nucleic acid amplification tests on respiratory and stool samples with or without lateral flow lipoarabinomannan assays to detect pulmonary tuberculosis disease in children - Olbrich, L - 2025 | Cochrane Library
Select your preferred language for Cochrane reviews and other content. Sections without translation will be in English.
http://bit.ly/45nlHCz
4 months ago
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Big news: @WHO approves 6 CAD tools for TB detection on chest X-raysâboosting case finding in high-burden settings. Proud that
#R2D2_TBnetwork
data contributed to the report.
#EndTB
#DigitalHealth
#TBscreening
#GlobalHealth
createsend.com/t/d-F03FD74C...
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WHO approves six software products for the computer-aided detection of TB on chest X-ray_June 2025
http://createsend.com/t/d-F03FD74C155DB77F2540EF23F30FEDED
4 months ago
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Our new multi-country study evaluates swab-based molecular tests for
#TB
, showing strong accuracy using both sputum and tongue swabs. Near point-of-care platforms like MTB Ultima and MiniDock MTB could help enable universal molecular testing.
www.medrxiv.org/content/10.1...
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Diagnostic accuracy of swab-based molecular tests for tuberculosis using novel near point-of-care platforms: A multi-country evaluation
Background: Swab-based molecular platforms that enable testing of both sputum (via swabs swirled in sputum) and tongue swabs are emerging as a promising option for more accessible and lower cost molec...
https://www.medrxiv.org/content/10.1101/2025.04.12.25325603v1
6 months ago
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In our study of 2,904 adults with
#TB
symptoms across five high TB-burden countries, CRP-based screening had 84% sensitivity and 61% specificity. Though CRP didnât meet minimum diagnostic targets overall, its accuracy varied by setting and subgroup.
www.atsjournals.org/doi/10.1164/...
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C-Reactive Proteinâbased Screening of People with Tuberculosis Symptoms: A Diagnostic Accuracy Study | American Journal of Respiratory and Critical Care Medicine
https://www.atsjournals.org/doi/10.1164/rccm.202405-1000OC
6 months ago
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Our study compared Ugandaâs
#TB
treatment decision algorithm for children with the WHO's. We found these TDAs can help diagnose more TB cases, but could also lead to overtreatment. Better tests are needed to confirm TB in children.
dx.plos.org/10.1371/jour...
#Tuberculosis
#ChildHealth
#Uganda
#WHO
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The Accuracy of the Uganda National Tuberculosis and Leprosy Program diagnostic algorithm and the World Health Organisation treatment decision algorithms for childhood tuberculosis: A retrospective an...
Author summary In this study, we assessed and compared the accuracy of the 2017 Uganda National TB and Leprosy Program (NTLP) algorithm with the 2022 World Health Organization (WHO) Treatment Decision...
https://dx.plos.org/10.1371/journal.pgph.0004026
6 months ago
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Despite being preventable,
#TB
affects thousands in the US. A major barrier to TB elimination is the lack of Medicare coverage for TB infection screening and testing. Our team describes how this policy gap affects US TB elimination efforts.
rdcu.be/efcBa
#TBPrevention
#Medicare
#CTB
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Policy Impediments to Tuberculosis Elimination: Consequences of an Absent Medicare National Coverage Determination for Tuberculosis Prevention
https://rdcu.be/efcBa
7 months ago
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California's health equity-driven approach during
#COVID-19
, using the Healthy Places Index, provided key insights into addressing disparities in testing, cases, and mortality. Learn how the state used data to guide policy and prioritize vulnerable communities:
dx.plos.org/10.1371/jour...
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The integration of health equity into policy to reduce disparities: Lessons from California during the COVID-19 pandemic
Racial and ethnic minoritized groups and socioeconomically disadvantaged communities experience longstanding health-related disparities in the United States and were disproportionately affected throug...
https://dx.plos.org/10.1371/journal.pone.0316517
7 months ago
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A study in Uganda among people living with HIV found newer short-course regimens could drive
#tuberculosis
preventive treatment acceptance from high to nearly universal.
#TB
www.medrxiv.org/content/10.1...
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Predicted choice and acceptability of regimens for tuberculosis preventive treatment among people living with HIV in Uganda â a discrete choice experiment
Abstract Introduction Little is known about how people living with HIV would choose if offered different tuberculosis preventive treatment (TPT) regimens, and under which conditions they would accept ...
https://www.medrxiv.org/content/10.1101/2025.03.12.25323350v1
7 months ago
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Our study in Uganda explores how social factors affect
#TB
diagnosis completion. Barriers like stigma, financial constraints, and limited support were identified. Integrating social and economic supports with clinical care is key. Read more:
rdcu.be/edUmz
#Tuberculosis
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Identifying mechanisms by which social determinants of health impact TB diagnostic evaluation uptake in Uganda: a qualitative study
https://rdcu.be/edUmz
7 months ago
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Social protection boosts TB treatment success! Our team's new study found that those receiving support had 2.23x higher odds of success. Read more:
www.medrxiv.org/content/10.1...
#TB
#HealthEquity
#SocialProtection
#GlobalHealth
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The impact of social protection interventions on treatment and socioeconomic outcomes of tuberculosis-affected people and households in low income, high burden settings: A systematic review and meta-a...
Introduction: Tuberculosis (TB) is the leading cause of death due to infectious disease worldwide. Social protection interventions can benefit TB-affected households. We conducted a systematic review ...
https://www.medrxiv.org/content/10.1101/2025.03.04.25323276v1
7 months ago
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