Vanesa Nieto Estevez
@vanesanieto.bsky.social
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Researcher at UTSA studying brain development and neurodevelopmental disorders
reposted by
Vanesa Nieto Estevez
Cell Reports
6 months ago
Dual developmental effects of ARX poly-alanine mutations on human cortical excitatory and inhibitory neurons
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Dual developmental effects of ARX poly-alanine mutations on human cortical excitatory and inhibitory neurons
Nieto-Estevez et al. show that ARX poly-alanine expansion mutations disrupt cortical and interneuron development in human brain organoids, revealing early network hyperactivity and offering insights into developmental epilepsies.
http://dlvr.it/TQJ8nk
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🧠 New year, new paper! Absolutely thrilled to share the final version of our manuscript on ARX brain organoids! 👩🏻🔬
www.cell.com/cell-reports...
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Dual developmental effects of ARX poly-alanine mutations on human cortical excitatory and inhibitory neurons
Nieto-Estevez et al. show that ARX poly-alanine expansion mutations disrupt cortical and interneuron development in human brain organoids, revealing early network hyperactivity and offering insights i...
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01518-9
7 months ago
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