Huiqing Zhou
@huiqingzhou.bsky.social
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Excited to share the most recent preprint from our lab. We report a directed evolution platform for m6A erasers and an FTO variant with 13-fold enhanced catalytic efficiency. The FTO variant shows promoted site-specific editing efficiency of m6A in human cells.
www.researchsquare.com/article/rs-7...
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Directed evolution of an m6A eraser for site-selective epitranscriptome editing
N6-methyladenosine (m6A) is a critical RNA modification, but tools to manipulate it in cells remain limited. Current m6A demethylases (FTO and ALKBH5) exhibit low catalytic efficiency, hindering their...
https://www.researchsquare.com/article/rs-7958216/latest
2 months ago
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Excited to share the most recent preprint from our lab. We report a directed evolution platform for m6A erasers and an FTO variant with 13-fold enhanced catalytic efficiency. The FTO variant shows promoted site-specific editing efficiency of m6A in human cells.
www.researchsquare.com/article/rs-7...
loading . . .
Directed evolution of an m6A eraser for site-selective epitranscriptome editing
N6-methyladenosine (m6A) is a critical RNA modification, but tools to manipulate it in cells remain limited. Current m6A demethylases (FTO and ALKBH5) exhibit low catalytic efficiency, hindering their...
https://www.researchsquare.com/article/rs-7958216/latest
2 months ago
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A follow-up interview with the editor
@cp-cellchembiol.bsky.social
to share our journeys and perspectives, along with our recent paper on MapID-tRNA-seq.
add a skeleton here at some point
8 months ago
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Happy to share a paper from our group on "MapID-tRNA-seq" for confidently identifying modifications by RT mutation signatures in human tRNAs. This method will enable future discoveries of modifications' occurrence and functions in tRNA biology and diseases.
www.cell.com/cell-chemica...
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MapID-based quantitative mapping of chemical modifications and expression of human transfer RNA
tRNA chemical modifications play critical roles in biology and diseases. Tepe et al. report MapID-tRNA-seq to map m1A, m3C, and multiple bulky modifications in tRNAs from HEK293T and breast cancer-rel...
https://www.cell.com/cell-chemical-biology/abstract/S2451-9456(25)00125-4
8 months ago
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