#NephMadness 2026: The PodCrawl Featuring these podcasts: - GN in Ten @isgd.bsky.social - Global Kidney Care @theisn.org - @freelyfiltered.bsky.social - @febrilepodcast.com - Kidney Commute @nkf-professionals.bsky.social - @coreimpodcast.bsky.social - Nephron Segment bit.ly/NM26Podcrawl

This #InternationalWomensDay, let's recognize the impact of kidney disease on women🌍 Women living with kidney disease face unique challenges, from delayed diagnosis to barriers in care during fertility, pregnancy, and postpartum.

Today’s race marked World Kidney Day by promoting kidney 🫘 health, prevention, and physical activity. We also recognize the leadership and contributions of women in health and society on International Women’s Day 👩🏻 #WorldKidneyDay #OurKidneysOurPlanet #IWD2026 @unwomen.bsky.social

🏃🏻‍♂️ #Run4Kidneys 🫘 #850Challenge #WorldKidneyDay #SockItToKidneyDisease 🧦 #Cochabamba 🇧🇴

ARDS & AKI often coexist in critical illness. A scoping review in J Crit Care found that 46.8% of patients with ARDS developed AKI across 28 studies. ARDS-AKI was also linked to higher hospital mortality vs ARDS alone. More studies are urgently needed. 🔗 doi.org/10.1016/j.jc...

🆕 in Nature Reviews Nephrology: our Review on social determinants of health & #AKI. A 🔑 message: improving AKI outcomes requires more than better clinical care—it also requires confronting social, structural and environmental inequities. 🔗 10.1038/s41581-026-01063-3 #AKI #Nephrology #KidneyHealth

🎓 PROGRAMA EDUCATIVO ANUAL SLANH Los Miércoles son de SLANH 🚀 Tema: EcoNefroLATAM: Salud Renal, Clima y Sostenibilidad 🗓 Miércoles 04 de marzo de 2026 ⏰ Horario 🕖 19:00 h 🇵🇦 🔗 Regístrate en: bit.ly/slanh04marzo 🌐 slanh.net #SLANH #Nefrología

Buenas noches 🌙 #KidneyRunners🏃🏻‍♂️ 🫘 #850Challenge

First run 🏃🏻‍♂️ of #KidneyMonth #Run4Kidneys 🫘 #WorldKidneyDay #850Challenge 🎗️

#JustDoItSunday 🏃🏻‍♂️ #Run4Kidneys 🫘 #850Challenge 🎗️

New in Nature Reviews Nephrology (Mar 2026) 🌍🩺🫘 I contributed to: “Climate change and AKI: heat, hazards and health-system readiness” (World Kidney Day collection). Extreme heat + environmental hazards raise AKI risk systems need readiness now. doi:10.1038/s41581-026-01048-2 #AKI #ClimateChange

#Run4Kidneys 🫘 🏃🏻 #850Challenge 🎗️

Heat isn’t just uncomfortable—it’s nephrotoxic at scale. 🌡️🩺 CJASN 📄 (US counties, 2005–2019): per +1°C annual avg temp, CKD prevalence +0.23 pp & kidney failure +1.37/100k. Heat-wave days also linked—strongest in high-poverty & nonmetro counties. 🔗 journals.lww.com/cjasn/fullte...

Después del trabajo 👨‍💻 🏥 una corta carrera de recuperación ❤️‍🩹 🏃🏻 #Run4Kidneys 🫘 #850Challenge

100 years ago (1926), Poul Brandt Rehberg introduced creatinine clearance to eGFR shaping how we assess 🫘 function today. A JASN perspective also honors his later life in the 🇩🇰 resistance, arrested by the Gestapo & his postwar science leadership. 🔗 journals.lww.com/jasn/citatio...

Pre-op SGLT2i use may protect kidneys 🫘 after surgery in T2D. In an Australian 🇦🇺 target-trial emulation (738 SGLT2i vs 1,761 no SGLT2i), AKI ≤7d: 18.6% vs 25.8% (29% lower odds). Consistent across subgroups. RCTs needed. #AKI #Diabetes #Surgery 🔗 doi.org/10.1111/dom....

Guidelines recommend finerenone for T2D+CKD to cut CV events & slow CKD👉🏻mechanistic analyses suggest ~90% of benefit is via proteinuria reduction, cheaper steroidal MRAs (e.g., spironolactone) also ⬇️proteinuria. Could they be a lower💲alternative? Head-to-head trial needed.

Editors’ Choice 2025: Impact of Simultaneous Initiation of Finerenone and Empagliflozin on Urinary Albumin-to-Creatinine Ratio in Asia: a Pre-Specified Analysis of CONFIDENCE Check out the paper here #ASNCJASN: kidney.pub/CJASN0865

The latest ASN Kidney Translation Podcast episode covers advances in kidney transplantation: an SGLT2i trial in kidney transplant recipients (CJASN), delivery outcomes after kidney transplantation (JASN), and strategies and policies for living donation (Kidney360). Tune in: kidney.pub/KTPOD022026

New 📑 activating transcription factor 4 (ATF4) (integrated stress response) links drug-induced AKI to pyroptosis. Tubular ATF4 ↑ with dysfunction; deleting ATF4 improves 🫘 function & inflammation. Pathway: ATF4 → STAT1/GBP2 → NLRP3 → pyroptosis. 🔗 journals.lww.com/jasn/abstrac...

𝗜𝗡𝗦𝗜𝗚𝗛𝗧, our newsletter is out! Read about: • Professor Donal O’Donoghue Global Kidney Policy Forum during #ISNWCN • New report from ISN i3C in @kidneyint.bsky.social • 10 new ISN INTCs • New ISN Academy curriculum • and more ➡️ www.theisn.org/news/insight...

Adjuvant thiazide outperformed simply increasing loop dose for boosting diuretic response in acute HF with diuretic resistance and response didn’t depend on the presumed mechanism of diuretic resistance. #HeartFailure #CardioRenal #Nephrology 🔗 journals.lww.com/jasn/fulltex...

CSA-AKI: immediate postop phase is critical. J Crit Care (UK, 2015–2024; n=1,530; matched 1:2): pts needing postop hemofiltration had higher in-🏥 mortality (23.1% vs 6.2%) & worse survival to 5y—but among 🏥 survivors, long-term survival was similar. 🔗 doi.org/10.1016/j.jc...

Novel immunotherapies can cause AKI. ICIs: severe acute interstitial nephritis is the key renal adverse event. CAR-T: cytokine release syndrome + IEC-associated HLH can injure kidneys via multiple mechanisms. Need better prevention & earlier diagnosis. 🔗 journals.lww.com/kidney360/fu...

A multicenter retrospective HRS-HARMONY study (11 🇺🇸 🏥 systems; n=374 cirrhosis + AKI requiring dialysis): HRS-AKI was not associated with higher 90-day mortality vs other AKI etiologies. Overall mortality 59.6%—similar to other AKI-dialysis cohorts. 🔗 journals.lww.com/kidney360/fu...

Proud to have been part of this newly published phase 2 RCT in AKI + iron deficiency (n=120). A single 1,200 mg IV iron dextran infusion was safe but did not reduce MAKE at 90 days vs usual care (82% vs 75%; p=0.37). #AKI #Nephrology #ClinicalTrials 🔗 journals.lww.com/kidney360/ab...

#JustDoItSunday 🏃🏻‍♂️ #Run4Kidneys 🫘 #850Challenge 🎗️ 2026

Supplementing with fish oil reduces the risk of serious cardiovascular events in patients receiving maintenance dialysis per a new randomized clinical trial. Read more in #ASNKidneyNews: kidney.pub/KN1801-26#ASNKidneyNews:

AI is becoming the backbone of kidney care. The #ASN 🤖 Workgroup urges responsible use: patient benefit first, clinician oversight, & innovation where burden is highest. AI should augment, not replace judgment. Transparency, validation + education. www.kidneynews.org/view/journal...

#AKI insights: response to ⚡️ • 17β-estradiol blocks ferroptosis (non-genomic+genomic) → sex diffs • AKI mtDNA mutations impair resilience; adenosine restores ATP & function • Hypoxia ↑ tRNA-Asp-GTC-3′tDR traps PUS7 → RNA autophagy → protection 🔗 doi.org/10.1038/s415...

Climate change is a kidney issue: heat stress, floods/water insecurity, dengue/lepto, pollution & nephrotoxins → more community-acquired #AKI—hitting outdoor workers & underserved communities hardest. “Heat-season” readiness can save lives. Read: rdcu.be/eY1G0

Large Danish matched study (2,815 Down syndrome; 1:10 controls) found consistently higher risks of AKI & CKD across adulthood—even among those without congenital heart disease. Kidney monitoring deserves more attention in this population. #DownSyndrome doi.org/10.1093/ckj/...

ABG is the gold standard, but arterial sticks hurt & carry risks. A Kidney360 study (5,419 paired samples) derived formulas to estimate arterial pH, pCO₂ & HCO₃⁻ from VBG—meeting acceptable clinical expectations. #Nephrology #CriticalCare #AcidBase journals.lww.com/kidney360/ab...

After preeclampsia, kidney risk persists. 171,693 pregnancies 🤰(FU 7y): preeclampsia → 2.53× severe albuminuria (>300 mg/g) & 2.18× eGFR<60. But in the 1st postpartum year: only 20% Cr and 10% albumin testing. #Preeclampsia #CKD journals.lww.com/jasn/abstrac...

SLANH 🌎 survey (Mar–Dec 2024; n=505; 20 LA countries): EBP for AKI 👉🏻IHD 98%, PD 65%, CRRT 59% (unavailable in 🇭🇹, 🇳🇮, 🇵🇾 & 🇻🇪). Advanced EBP scarce: ECMO 16.7%, ECCO₂R 7%. Top training needs: ECMO, ECCO₂R, CRRT, TPE. @SLANH_ #AKI #EBP 🔗 doi.org/10.1159/0005...

Hi, I’m Cello Tonelli, President of the ISN. Join us for the #ISNWCN in March. Register today ➡️ lite.spr.ly/6007Ol8D

PPIs have been linked to AKI/CKD risk. A 📑 in 🇰🇷 found P-CAB users had fewer kidney events than PPI users: creatinine doubling and eGFR ≥50% decline were lower; adjusted risk reductions 48% and 37%. Observational—needs confirmation. 🔗 doi.org/10.1093/ckj/...

AKI is rising 🗺️ hit hardest in LMICs. The 5R framework (Risk, Recognition, Response, Renal Support, Rehab) guides action: advocacy + access, better detection, patient-centered care, closing gaps, equity & climate action, & tools like POC tests, EMRs, digital health & AI. #AKI

Grow professionally with the ISN. Access high-impact scientific and clinical research through our journals. Join/renew your ISN Membership ➡️ http://lite.spr.ly/6... #ThisIsISN - Advancing kidney health worldwide. Together.

Non-tunneled vs tunneled HD catheters: a 301-patient study found no significant difference in CRBSI rates with pre-curved non-tunneled catheters vs tunneled. Suggests longer use may be reasonable while awaiting AVF/PD cath/transplant. doi.org/10.1093/ckj/...

As the year draws to a close, we invite you to look back at 25 KDIGO resources from 2025, organized alphabetically by topic. KDIGO wishes you a happy and healthy 2026! KDIGO 25 from 2025: kdigo.co/25-from-2025

🌍🏃‍♂️ We’re ending the year running around the world: 3 continents (Americas, Europe, Asia), 7 countries (🇧🇴🇪🇨🇺🇸🇮🇳🇩🇪🇵🇦🇲🇽) & 10 cities—1,450 km total. Proud to complete the #850Challenge again, raising kidney disease awareness worldwide. 💚🩺🌎 #Run4Kidneys 🫘

Feliz navidad 🎄 #KidneyRunners 🏃🏻‍♂️ 🏃🏻‍♀️ 🫘 #850Challenge #Run4Kidneys

Key updates on IgAN & complement-mediated kidney disease from KI/KIR: felzartamab, vWF–platelet targeting, and advances in C3G & IC-MPGN. Plus endotyping, biomarkers, and trial updates refining risk stratification & therapy. ISN eDigest team 👏🏻 🔗 www.theisn.org/edigest-isn-...

VTL-308 post-hoc 📑 (n=151) in severe alcohol-associated hepatitis, AKI → higher 90-day mortality. Higher bilirubin ↑ AKI risk; corticosteroids were linked to ↓ AKI incidence. After AKI, steroids didn’t improve recovery; high bilirubin ↓ reversal. 🔗 doi.org/10.1038/s415...

POCUS is changing nephrology at the 🛌 answering focused questions fast and sharpening decisions. But untrained use can cause diagnostic errors and harm. As adoption grows, we need standardized training + certification to keep #POCUS safe and effective. doi.org/10.62716/kn....

Inactive lupus nephritis & SGLT2i data: NDT cross-over trial (n=30). Dapagliflozin + standard care vs usual therapy for 6 mo; 9 excluded (flare/LTFU). Proteinuria ↓ –36.1% vs –3.5%. More hypotension symptoms; no sig BP/weight changes. #LupusNephritis 🔗 doi.org/10.1093/ndt/...

In 102 PICU children 🇮🇷 Ultrasound ❤️ Output Monitoring showed CI as the only useful USCOM predictor for early AKI. AUC: CI 0.66 vs RAI 0.70. +RAI ↑ AKI risk 6.23x; abnormal CI 3.92x. PPV 60% (RAI) vs 57.1% (CI). USCOM may complement RAI. #AKI 🔗 doi.org/10.1007/s004...

Our 🆕 review out in Nature Reviews Nephrology! We discuss the global epidemiology of #AKI why major gaps and inequities persist 🗺️ , & practical opportunities to improve outcomes through the 5R framework, stronger surveillance, & digital/innovation-enabled care. www.nature.com/articles/s41...

After 🏥#AKI, albuminuria at 3 months is recommended—but often missed. In 554 CRIC pts, uPCR measured within 1 year still strongly predicted risk. Each doubling of proteinuria → ~3x higher kidney disease progression risk. #AKI to #CKD 🔗 journals.lww.com/kidney360/ab...