1/n Have you ever wondered whether an amplified oncogene in a patient’s tumor (HER2/EGFR/CCND1/…) is carried on extrachromosomal DNA (ecDNA) vs embedded within a chromosome? Bulk WGS + genome graph can hint, but in practice it’s often hard to resolve. Here is our new preprint.

Today marks a meaningful milestone -- I am starting as a lab investigator and thoracic oncologist at MSKCC, focused on improving treatment through a deep understanding of cancer evolution. I will soon be looking for fellow travelers on this mission. Stay tuned!

Harold Varmus on science policy today www.nytimes.com/2025/02/14/o...

An amazing work utilizing Cre-LoxP system creating oncogene amplification by ecDNA. Fascinating parallels with human liposarcomagenesis. Huge congratulations to the Ventura lab and the whole team!