ADNP:p (activity dependent neuroprotector homeobox) has a single homeodomain (HD): the most cward of the small structured regions in the diagrams below. There are at least 5 phosphoIDRs, most of which flank the homeodomain, particularly those cward of the HD that are arranged enfilade. #proteomics

Day 4 of the current geomagnetic storm is maintaining a high level of #aurora activity.

How would you have done it? #obliquestrategies

My own, special version of "Where's Waldo?" for #proteomics would be something like "Where's the Bait?".

A "good news" story. https://www.chosun.com/english/national-en/2025/09/23/B3ZEYVBMNBDMRHJL5SP7SJOLAI/

Hurricanes Humberto and Imelda have made their predicted turns to the east. Imelda is now expected to run right over Bermuda, while Humberto won't make landfall until it gets to Europe.

Day 3 of the current geomagnetic storm is keeping the #aurora popping.

I have found it increasing challenging to watch (or listen to) programs/podcast about issues of the day once I realized that the hosts, commentators & politicians routinely base their arguments on rather obvious logical fallacies.

Something to bring up if anyone tells you that big investment banks are hard to fool. https://www.usatoday.com/story/money/2025/09/30/charlie-javice-ceo-frank-sentenced-defrauding-jpmorgan/86434405007/

With a few pharma mergers "Colours USA" is a very real possibility. https://www.forbes.com/sites/zacharyfolk/2025/09/30/trump-announces-trumprx-website-offering-discounted-prescription-drugs/

AKT1S1:p (Ras-related C3 botulinum toxin substrate alpha serine/threonine-protein kinase one substrate one) has nward & cward phosphoIDRs. MTOR & AKT1 are the main suspects for causing the phosphorylation. Tryptic peptide with >1 phosphorylation are the rule with this one. #proteomics

There is still a geomagnetic storm going on, so the #aurora prediction suggests it should be visible, at least in Canada and the northern states.

There already is one Gal Gadot. Is there really a need for her creepy, de-aged avatar? https://variety.com/2025/film/global/ai-actress-tilly-norwood-talent-agents-zurich-summit-1236533454

Weekend warrior "major" (who probably won't be around next year) trying to threaten a room of career flag officers. https://www.nbcnews.com/now/video/hegseth-says-military-leaders-who-disagree-with-his-directives-should-resign-248728645895

HCLS1:p (hematopoietic lineage cell-specific protein 1) has a simple, high occupancy S/T+phosphoryl pattern & a rhyming, diffuse, low occupancy Y+phosphoryl pattern. The Y acceptors are believed to be marked via FES, FGR, FYN, LYN or SYK. #proteomics

At some point he is going to require an executive producer credit (& maybe a cameo) on all movies, too. https://www.bbc.com/news/articles/c4g78e809zqo

A modest geomagnetic storm has kicked up some flare in the #aurora, at the moment best seen in north central Asia.

"Our findings challenge narratives of imminent labor market transformation due to Generative AI." https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5219933

EPS15L1:p (epidermal growth factor receptor pathway substrate 15 like 1) is an evolutionarily conserved paralog of EPS15:p. It has a similar arrangement of the 4 nward structured domains, but has detailed differences wrt its phosphoIDRs. The paralogs do not share any tryptic peptides. #proteomics

The models seem to be agreeing that both storms Imelda & Humberto will be getting the bum's rush eastward out to sea starting Tuesday, driven by the same upper level steering winds.

To my American friends: is the current deployments of troops against US cities part of a "cold civil war" or a "civil cold war"?

EPS15:p (epidermal growth factor receptor pathway substrate 15) has a single EGFR kinase signal acceptor (hs: Y849; mm: Y850), but plenty of S/T acceptors for other kinases. These acceptors flank the nward EF-hand pair & in at least 3 cward phosphoIDRs. #proteomics

Can the Fixome be far behind? https://www.biorxiv.org/content/10.1101/2025.09.25.678591v1

EPS8:p (epidermal growth factor receptor pathway kinase substrate 8, signaling adaptor) has 2 larger nward protein-protein domains & 2 smaller ones cward (SH3 & SAM). The highest occupancy S/T phosphoIDR is between the cward domains, with grace notes around the edges of those nward. #Proteomic

I heard a podcast the other day with a science journalist being interviewed. He was very adamant about the problems with describing DNA as the "blueprint for a cell". I didn't think much of it at first, but I must admit that his arguments have won me over as I thought about it.

While it may seem like the right thing to do now, why was all this allowed to be put into place to start with? https://www.theguardian.com/world/2025/sep/25/microsoft-blocks-israels-use-of-its-technology-in-mass-surveillance-of-palestinians

Breaking (and we do mean breaking)! #ontario #dougford #cars

PACSIN1:p (Protein kinase c And Casein kinase Substrate In Neurons 1) has an nward coiled-coil dimerisation domain & a cward pTyr-peptide binding domain (SH3). Between them is a phosphoIDR that is both the protein's defining characteristic & too complex to really understand. #proteomics

Hurricane Gabrielle is set to make a direct hit on the Azores.

I understand the motivation behind this sort of article, but I disagree with it wholeheartedly. https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1013505

IRS2:p (insulin receptor substrate 2) is named for its pTyr kinase, but it is also a riot of pSer/pThr acceptors. I don't think there is a technical name for this type of structure made up of many low-complexity phosphoIDR regions, but there really should be. #proteomics

I can remember, back in the old days, when printing something after not printing anything for a few weeks did not require 4 hours of on-line research & multiple rounds of print nozzle/power cleaning from obscure places in your printer utilities menu.

Rather than pursuing villains, removing barriers to pre- and post-natal care for all US residents would probably produce the largest positive effect on public health of any policy alternative.

DAB2:p (disabled homolog 2 adaptor protein) has a bright nward phosphotyrosine binding domain and the sort of odds-and-sods S/T phosphoIDRs that defies analysis by molecular biology methods, e.g. alanine scans. #proteomics

NO! A thousand times NO! https://www.bbc.com/news/articles/cx27lj39e99o

Tropical Depression Bualoi is expected to take a quick swipe at Manila as a Typhoon some time Thursday night.

I'm always delighted to see that CNPN is still actively promoting things, although I do miss the old logo. https://us02web.zoom.us/webinar/register/WN_8S3ODi8OS0eZ-QdJ0kL2qg#/registration

Hurricane Gabrielle is blowing quite a gale in the north Atlantic, while Invests 93L and 94L are still all potential.

An under-appreciated consequence of this sort of announcement is that the NIH is going to be tasked with funding as many grants as necessary aimed at specifically proving these conclusions. https://www.bbc.com/news/articles/cdx2rk10ep0o

SGIP1 (SH3-containing growth factor receptor bound protein 2-like interacting endocytic adaptor 1) is a peppy little guy, with a cward muniscin domain that features a long rectangular twisted β sheet. The rest of the protein is a Gordian knot of a phospho-IDR that awaits its Alexander. #proteomics

Although it may not be a given that productivity matters, so long as share holder value goes in the right direction this quarter. https://hbr.org/2025/09/ai-generated-workslop-is-destroying-productivity

I guess we can add "practising medicine without a license" to the list, although I can't for the life of me understand the thought process that led here. https://www.cbc.ca/news/world/trump-autism-tylenol-1.7639889

Super Typhoon Ragasa has passed Luzon on its way towards the Chinese Mainland.

This is an official US government web site announcing an official government program. https://trumpcard.gov/

PEA15:p (proliferation and apoptosis adaptor protein 15) is an acronym for its previous name "15 kDa phosphoprotein enriched in astrocytes". The nward block is a death domain (2 bundles of 3 helixes) originally discovered in caspase binding proteins. Is it really an "adaptor protein? #proteomics

The decision to experimentally attack the problem of protein-protein interactions at the level of intact proteins rather than specific interaction domains with known 3D structures (SH2, SH3, RING, CARD, etc.) I would rate as one of the biggest missed opportunities in the history of proteomics.