Anyone have experience with fosmanogepix expanded access or high dose ibrexafungerp for refractory esophageal candidiasis?

This is such a farce, honestly.

I don’t think people understand how great it is to have Bobby Mukumala at the helm of AMA in this moment. Met him in med school, and knew he was going to be a leader, but also knew advocacy and public health well for someone not directly performing those tasks.

We diagnose trisomy 21 and other defects in the first trimester. This is just nonsensical. The chair of the ACIP is making things up, and which is unsurprising to say the least…..

Better yet, just don’t use vancomycin

The Social Darwinism/soft eugenics theories of MAHA become unsettlingly clear when you start looking closely

Kulldorff points out that low rates of COVID-19 vaccination are a reflection of a lack of trust in vaccination, as though this is a tragic accident he spectated rather than something he played an active role in

cardiovascular morbimortality later in life and raises the issue of subclinical myocarditis (i.e., myocarditis develops but you don't experience any symptoms). This is something that is being actively followed- the long-term significance of these imaging changes cannot be known in advance.

Absolutely not. This is the opposite of what should be happening and 100% uptake should be the target. You hate to call them hacks, but you don’t ask this question unless this is what you want

Meissner asks if public uptake ought to influence ACIP recommendations. This is the game right there. The vaccines are safe and effective and a benefit to all ages. But these contrarians have sowed doubt in them and are using that to kill them.

Hepatitis B can be passed from parent to baby at birth - and when that happens, the consequences can be deadly. It is unscientific and dangerous to intentionally ignore the success of U.S. vaccination programs or argue that the U.S. should not vaccinate babies for hepatitis B at birth.

I’m a hospital infection control person, this is an exceedingly dumb question.

"Maybe vaccination is making you more vulnerable to more viruses. Perhaps they vaccine efficacy really means vaccine less efficacy" (WTF)

It’s apparent these ACIP members have never attended a previous ACIP meeting as the format and breadth of data presented by the CDC is exactly the same as provided at every single meeting I’ve watched since 2020.

Kuldorff made a nonsensical comment about test-negative designs not being reflective of the general population in their control group. The control group is literally community members who happen to have a different infection that resembles COVID-19.

Just makes earlier this year announcement to remove approval even more unconscionable.

Malone, who is part of several anti-vax orgs, says he has no conflicts. This is ridiculous.

>90% chance of becoming chronic infection if acquired in infancy (under 1 year old) which risks fibrosis AND with 20-25% chance of hepatocellular carcinoma It's an anti-cancer vaccine in babies

Kulldorff also recycles anti-vaccine propaganda about the birth dose of hepatitis B virus (HBV) vaccine. This is not universally done across the world- mainly in those countries where there is a low rate of chronic infection. The US, however, has millions of chronically infected carriers.

No. Absolutely not. This is a stupendously dumb idea. It is entirely preventable because there are people who don’t know they have Hep B. It needs <20 particles to infect, which is stupidly low numbers.

The Pediatric Infectious Diseases Society has elected not to have our liaisons to ACIP participate in today's meeting. We believe the politicization of the committee renders it incapable of an independent, credible, data-driven process to review and recommend vaccines for the American public.

It’s rich to complain of “false statements” about new “ACIP” members by people using non-existent references in their statements about vaccines #RFKLies #ACIP

Hearing from all corners of HHS this morning about a total bloodletting — firings of scientists, analysts and many more as delayed RIFs take effect. Many folks didn’t see early AM email and showed up, only to be turned away when badges didn’t work. Was sent this photo of long lines at one HHS site.

Vandalism is too mild. This is arson, with millions trapped in the building.

#Breaking: HHS starts layoffs of thousands of workers across its agencies www.statnews.com/2025/04/01/h...

This horrific story has been confirmed to me by a colleague at the same institute as this scientist. The US is not a safe place to run an academic conference. @theguardian.com have an English language version of this story: www.theguardian.com/us-news/2025... 🔭🧪

Taking a nuclear bomb to the research capacity of the United States as a whole, possibly setting back decades of progress

So all NIH websites appear to be down.

Why are the NIH HIV treatment guidelines offline? What absolute nonsense is this??

The world is less without Dickson Despommier. His voice has guided me through myths of virology and parasitology since medical school, among the others from TWiP and TWiV, especially during the pandemic and ID fellowship. Glad to have my signed copy of Parasites.

It’s hardly fashionable, but the IDSA needs to understand that the seat at the table can only be had while there is a table. Right now the house is on fire, and we need to deal with that before we think about the table.

Merry Christmas! lol @ me for doing an extended review for our clinical guidelines @umasschanid.bsky.social only to have this potentially drop off market

NEW: “Eat What You Kill” Hailed as a savior upon his arrival in Helena, Dr. Thomas C. Weiner became a favorite of patients and his hospital’s highest earner. As the myth surrounding the high-profile oncologist grew, so did the trail of patient harm and suspicious deaths. @davidmcswane.bsky.social

We're here now! @sheaepi.bsky.social

As an elder millennial at this point, I remember enough about the early 2000s hip hop that I will not be comfortable calling them “skeets”

the most important survival strategy we can adopt in this new world is to pick one guy to blame for everything going wrong and really just tear his life apart. this brings me back to the subject of Jared Leto,

Well making an effort here now. The other side is going to get real nasty and I’m tired of ads for certain types of male influences nut jobs and cranks. Previously had multiple accounts, but not sure I can stand that much more social media.