Carman Li (@carman-mc-li.bsky.social)

Brca1 haploinsufficiency promotes early tumor onset and epigenetic alterations in a mouse model of hereditary breast cancer - Nature Genetics A second hit to Brca1 in heterozygous mice leads to accelerated tumor development compared to wild-type mice in which both alleles are simultaneously deleted. This is because of an epigenetic state as... https://www.nature.com/articles/s41588-024-01958-6