Helen Willsey
@goodfrognosis.bsky.social
📤 617
📥 593
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Dissecting psychiatric disorders using frogs (she/her) willseylab.com
pinned post!
Check out our new preprint led by
@elinakosty.bsky.social
identifying convergence of autism proteins at the cilium (including chromatin regulators and synaptic proteins)! Makes us realize the deep similarity between neuronal synapses and cilia. Power of 🐸 for discovery
add a skeleton here at some point
10 months ago
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I can confirm the NIH is still working well enough to score my R01 terribly 😂🤪
8 months ago
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Congratulations to newly PhD'ed
@pieceofkate.bsky.social
Dr. McCluskey!! She gave a fantastic thesis seminar to cap it off 👏🎓🐸✨
8 months ago
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Appreciate this generous write up on our recent preprint!
www.thetransmitter.org/spectrum/hai...
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Many autism-linked proteins influence hair-like cilia on human brain cells
The finding may help explain autism’s association with multiple co-occurring conditions that involve cilia defects.
https://www.thetransmitter.org/spectrum/hair-like-cilia-on-human-brain-cells-harbor-many-autism-linked-proteins/
9 months ago
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My New Year’s resolution is to be kind… of a bitch.
9 months ago
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Check out our new preprint led by
@elinakosty.bsky.social
identifying convergence of autism proteins at the cilium (including chromatin regulators and synaptic proteins)! Makes us realize the deep similarity between neuronal synapses and cilia. Power of 🐸 for discovery
add a skeleton here at some point
10 months ago
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reposted by
Helen Willsey
Matyas Bubna-Litic
10 months ago
It's
#FluorescenceFriday
again! Some more
#Xenopus
... This time a
#gastruloid
formed by treating an explant of blastula presumptive ectoderm cells with Activin. Nuclei labelled with H2B-mCherry with colour indicating size.
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reposted by
Helen Willsey
Dr. Peter Walentek (Walentek Lab)
11 months ago
Another preprint from the lab and a collaboration with Miriam Schmidts and her lab from Uniklinik_Fr pediatrics. This work was carried out mostly by fantastic MD MOTIVATE student Henrike Berns. Funded by
@dfgpublic.bsky.social
@cibss.bsky.social
and SFB1453_NephGen.
www.biorxiv.org/content/10.1...
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A homozygous human WNT11 loss-of-function variant associated with laterality, heart and renal defects
Wnt signaling plays important roles during vertebrate development, including left-right axis specification as well as heart and kidney organogenesis. We identified a homozygous human WNT11 variant in ...
https://www.biorxiv.org/content/10.1101/2024.11.14.623711v1
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reposted by
Helen Willsey
Babli Adhikary
11 months ago
Hello science peeps A quick introduction to Miller lab shenanigans 🐸😄
@umichlawlib.bsky.social
We are very demure, very mindful labmates 🧪 🥼
#Scienceisfun
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Check out our new ✨preprint✨ led by James Schmidt! Here we identified a new role for the gene KANSL1 in ciliary biology using Xenopus, with validations in patients with associated Koolen-de Vries Syndrome, which is characterized by hypersociability.
www.biorxiv.org/content/10.1...
11 months ago
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reposted by
Helen Willsey
Kirsty Wan
11 months ago
okay has anybody made one of these for
#cilia
peeps yet??
go.bsky.app/ELfYqxw
please find & add more names below...
add a skeleton here at some point
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reposted by
Helen Willsey
Alliance of Genome Resources
about 1 year ago
Xenopus researchers (and only Xenopus researchers!) Open now!
Xenbase.org
wants to hear from you about how you use Xenbase and what they can do to make Xenbase even better. Just click
forms.gle/5WFANQTKA6TuSyg67
to take the survey!
#science
#biology
#devbio
#xenopus
#frogs
@xenbase.bsky.social
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reposted by
Helen Willsey
Matyas Bubna-Litic
11 months ago
Let's kick things off with live imaging of Xenopus deep layer blastocoel roof cells imaged using Airyscan 2.
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reposted by
Helen Willsey
Frog Wranglers
11 months ago
Hello world! We’re here to spread the love of our favorite model organism Xenopus. Give us a follow for your daily moment of Xen(opus)!
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reposted by
Helen Willsey
Dr. Peter Walentek (Walentek Lab)
11 months ago
New preprint from the lab 🙌 @biorxiv. We found new foxi1 functions in multipotent mucociliary progenitors in
#xenopus
. 🐸
www.biorxiv.org/content/10.1...
Congrats to 3 first authors Sarah Bowden, Magdalena Brislinger-Engelhardt, Mona Hansen & team! Fu dwd by CIBSS SFB1453_NephGen dfg
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Foxi1 regulates multiple steps of mucociliary development and ionocyte specification through transcriptional and epigenetic mechanisms
Foxi1 is a master regulator of ionocytes (ISCs / INCs) across species and organs. Two subtypes of ISCs exist, and both α- and β-ISCs regulate pH- and ion-homeostasis in epithelia. Gain and loss of FOX...
https://www.biorxiv.org/content/10.1101/2024.10.27.620464v2.abstract
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