@mlodziklab.bsky.social
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reposted by
@LaBonneLaB
9 months ago
Our values and resolve are only strengthened by recent events.
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reposted by
SCBRMSinai
18 days ago
Two exciting preprints from
@mlodziklab.bsky.social
lab. In the first preprint, Vuong and Mlodzik describe a novel, essential factor for bcatenin translocation to the nucleus, a big step forward to understand nuclear bcatenin localization.
www.biorxiv.org/content/10.1...
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A novel conserved protein associates with the IFT-A complex to mediate nuclear translocation of β-catenin in Wg/Wnt-signaling
Wingless (Wg)/Wnt signaling is critical throughout development and tissue homeostasis and associated with many disease states. Canonical Wg/Wnt-signaling is mediated by β-catenin (Arm in Drosophila ) ...
https://www.biorxiv.org/content/10.1101/2025.06.21.660855v1
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reposted by
SCBRMSinai
18 days ago
In the 2nd preprint from
@mlodziklab.bsky.social
, Weber et al. show that LRP5/6/arrow, the Wnt/bcatenin signaling specific co-receptor, is also required for Wnt/planar cell polarity establishment, a challenge and eye-opener for the Wnt field.
www.biorxiv.org/content/10.1...
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The Wnt co-receptor Arrow-LRP5/6 is required for Planar Cell Polarity establishment in Drosophila
Wnt-signaling, via β-catenin or the planar cell polarity (PCP) branch, is crucial for development, tissue homeostasis, and linked to many diseases. LRP5/6, arrow ( arr ) in Drosophila , is the obligat...
https://www.biorxiv.org/content/10.1101/2025.09.22.677847v1
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