Eric Wang (@wanglab.bsky.social)

Epigenetic reactivation of the tumor suppressor ZBTB7A by KDM4 inhibition in human acute myeloid leukemia CRISPR screens identify ZBTB7A as a tumor suppressor gene, and therapeutic targeting of KDM4 restores its expression to promote AML differentiation. https://www.science.org/eprint/W9M5JXKP5WFK2AYCB33V/full?activationRedirect=/doi/full/10.1126/scitranslmed.ady2936https://www.science.org/eprint/W9M5JXKP5WFK2AYCB33V/full?activationRedirect=/doi/full/10.1126/scitranslmed.ady2936