May the (icy) force be with you ⚔️: This month's scientific picture comes from Abhirup Majumdar (Fiedler lab). This ice sculpture was formed at the base of a flask during an exothermic reaction at low temperatures 🧊. Great contribution!

New study by @noalipstein.bsky.social and Nils Brose, @mpi-nat.bsky.social links UNC13A gene variants to a new developmental disorder — offering insights into ALS and potential therapies. 👏 Read the full paper: www.nature.com/articles/s41...

Congrats to Sigrid Milles, junior group leader at @fmp-berlin.de on receiving a Boehringer Ingelheim Stiftung Exploration Grant! 🎉 Her team studies how flexible, intrinsically disordered proteins form condensates to control clathrin-mediated endocytosis — combining NMR, smFRET & live-cell work. 🧫🫧

Neue Episode im Wirkstoffradio! WSR088 LNDW 2025: Depression & intrinsisch unstrukturierte Proteine mit Gästen aus dem @fmp-berlin.de www.wirkstoffradio.de/2025/10/12/w... #LNDW #Wissenschaftspodcast #Medizin #Podcast #Leibniz #Berlin #Depression #IDP

Our scientific picture of the month sets a spooky vibe 👻🎃 Thanks to the @broichhagenj.bsky.social lab for providing us with Chem o'lanterns

Congratulations to @volkerhaucke-lab.bsky.social for receiving the prestigious Reinhart Koselleck Grant by the @dfg.de (German Research Foundation) once again! 🎉 www.linkedin.com/feed/update/...

Congrats to Volker Haucke, Director at the Leibniz-FMP on being awarded the Ernst Schering Prize 2025 for his pioneering work on the function of signaling lipids that control how cells respond to hormones, nutrients and messengers.

🔥After years of hard work, it's finally out in @natchem.nature.com🔥 The Hackenberger group @fmp-berlin.de developed #🎯DarT-labeling, a #photocatalyticproximitylabeling method using deazaflavin - a ✅ biocompatible ✅ easily synthesized ✅ chemically benign #photocatalyst www.nature.com/articles/s41...

Daniel Roderer and his group revealed the first high-res structure of Fap2 from Fusobacterium nucleatum (cryo-EM/ET). Fap2 binds immune cells (TIGIT) and colorectal cancer cells (Gal-GalNAc), showing how Fusobacteria colonize tumors and escape the immune system. www.nature.com/articles/s41...

Brace yourselves! Arif from the Fiedler lab discovered+characterized in collaboration with us & other groups within the @fmp-berlin.de a novel PTM: autocatalytic oligophosphorylation (up to 6 Phosphates 😲). Still mysterious in origin, function & regulation. www.nature.com/articles/s41...

I am happy to share our new article on dynamic Eps15 and Dab2 networks in endocytosis studied by #NMR, and forming #LLPS. Research was done at @fmp-berlin.de and at the Institut de Biologie Structurale (IBS). www.nature.com/articles/s41...

Great work by @broichhagenj.bsky.social at Leibniz-FMP, David Hodson at @rdm.ox.ac.uk and the whole team!

⏰Join us for the NMR Symposium, Nov 26–27, 2025, celebrating our new 1.2 GHz NMR spectrometer. To present a poster, send your abstract to [email protected]. Registrations are open until September 15th!

Great cover art by @barthvanrossum.bsky.social for @jacs.acspublications.org: Influenza lifecycle showing M2’s roles, from activation in the low-pH endosome to viral uncoating, RNA release, and budding of new particles. View the article from the Lange lab here: pubs.acs.org/doi/10.1021/...

Thanks to Yanwei Su from @volkerhaucke-lab.bsky.social, we have a new scientific image of the month: When morphology gets romantic 🫶- this is a U2OS cell overexpressing Sec61b (ER), stained with LAMP1 (lysosome) and DAPI (nuclei), to test lysosome–ER membrane contact sites.

PhD position on studying intrinsically disordered proteins by NMR and single molecule FRET, Dr. Sigrid Milles, The Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmp-berlin.de Berlin, Germany leibniz-fmp.softgarden.io/job/58144047... #NMRjobs #NMRchat #NMR 🧲

Our scientific image of the month July comes from Kati Fischermanns, @broichhagenj.bsky.social lab and is titled: "96 wells celebrate diversity" 🌈 It was created by scaling up tunable photocontrol over cells.

With his exceptional work, Prof. Dr. Volker Haucke @volkerhaucke-lab.bsky.social has made it onto the #FallingWallsFoundation shortlist for the #ScienceBreakthrough of the Year 2025 in the #LifeSciences category. Congratulations!

The #LongNightoftheSciences at @fmp-berlin.de was a great success: Many visitors took a look behind the scenes during the lab tours and were inspired by research. Thanks to everyone who came and see you around next year!

Kampf dem Kunststoff! In der Forschung fallen Unmengen #Plastikmüll an. Lässt sich das ändern? www.leibniz-magazin.de/alle-artikel... #LeibnizMagazin #Müll #Nachhaltigkeit #Forschung @fmp-berlin.de

New in @jacs.acspublications.org: New insights into the flu virus: The Lange lab used proton-detected solid-state NMR combined with the Sun lab's expertise in QM/MM+MD simulations to reveal how pH changes drive conformational shifts in the influenza A M2 channel. pubs.acs.org/doi/10.1021/...

Wonderful to present my work leading a large European consortium around @fmp-berlin.de and @eu-openscreen.bsky.social at #ELMI2025. We produce large-scale #open-source high quality Cell Painting data for drug discovery 💊. First dataset published: doi.org/10.1016/j.is... Stay tuned for more!

Get ready for this upcoming event: Lecture series on Allostery in Drug Discovery 💊 www.linkedin.com/feed/update/...

The lab of noalipstein.bsky.social introduced a new mouse line to label presynaptic terminals with chemical dyes, enabling imaging of fixed & live neurons at confocal & super-res. They synthesized & validated a cell-impermeable dye, BG-SiR-d12, improving image quality! pubs.acs.org/doi/10.1021/...

Big step for open science! 🎉 Our @eu-openscreen.bsky.social consortium drops their first open Cell Painting dataset. Wolff et al. 2025: doi.org/10.1016/j.is... FAIR, high-quality & ready to power AI in drug discovery. 100K+ compounds coming in 2025! #OpenData #CellPainting #DrugDiscovery

FMP-Director Volker Haucke in @tagesspiegel.de: Why we should not accept the US government's attack on science. www.tagesspiegel.de/wissen/gleic... (article behind paywall)

Join us for the CytoData Symposium and Hackathon: cytodata25.eu-openscreen.eu Registration open now! Symposium November 20–21, 2025 Hackathon November 17–19, 2025 @eu-openscreen.bsky.social @mdc-berlin.bsky.social @fmp-berlin.de @cytodata.bsky.social

Today was #GirlsDay 2025: An opportunity to show girls at @fmp-berlin.de what science has in store for them: www.linkedin.com/feed/update/...

🎉 Freie Wissenschaft. Starke Forschung. 30 Jahre Leibniz-Gemeinschaft. 🎉 Am 31.3.1995 wurden wir unter dem Namen „Wissenschaftsgemeinschaft Blaue Liste“ gegründet – ein Ergebnis der deutschen Wiedervereinigung & ein erfolgreicher Beitrag zum Zusammenwachsen der Wissenschaft in Ost und West. (1/4)

Congratulations to @volkerhaucke-lab.bsky.social for receiving the Gottfried Wilhelm Leibniz Prize 2025 by @dfg.de The award recognises Haucke's research on lipid signaling and synaptic transmission in the nervous system. Insights into his work can be found here: www.youtube.com/watch?v=rl8m...

Read the latest article with Prof. @volkerhaucke-lab.bsky.social in @tagesspiegel.de www.tagesspiegel.de/wissen/wisse...

Congratulations to Dr. Christopher Schmied from @fmp-berlin.de for winning the #EinsteinFoundationAward. Together with Helena Jambor, the scientists were recognized for their project "PixelQuality," improving scientific image publication practices.

This month's scientific image runs under the motto: "Can't see the forest for the trees". It's an overloaded negative stain EM of DIBMA-nanodiscs that didn't break and caused this crystalline aggregates 💠Thanks to @hsawczyc.bsky.social (Lange lab) for providing us with this gem!

The scientific image of the month February shows two clawed frogs (Xenopus laevis) in their colorful underwater world 🐸 Big thanks to Martina Lauersdorf!

Mariposa Microscopy 🦋First Scientific Image of 2025 from Maria Kowald (@LipsteinNoa Lab) and @TolgaSoykan (Lehmann Lab) shows a cerebellum slice from a mutant mouse that was stained with a SNAP-tag ligand, producing a beautiful butterfly-shaped signal. #Microscopy #Neuroscience

Exciting news! @LeibnizFMP, @kieluni & @LeibnizLIV are starting new project, supported through "Leibniz CooperativeExcellence" program. Goal: Unravel mechanisms of K2P potassium channels – with potential new therapeutic approaches. https://t.co/1MeuAOMDXQ #LeibnizWGL @HanSun_lab

🎉 Congratulations! Prof. Volker Haucke @VolkerHaucke receives the #LeibnizPrize 2025 from @dfg_public for his groundbreaking research on #LipidSignaling & synaptic transmission. 👏 #Science #Research https://x.com/dfg_public/status/1866784732463423945

🎉 Herzlichen Glückwunsch! Prof. Volker Haucke @VolkerHaucke erhält den #LeibnizPreis 2025 der @dfg_public für seine bahnbrechende Forschung zu #Lipidsignaling & synaptischer Signalübertragung. 👏 #Wissenschaft #Forschung https://x.com/dfg_public/status/1866784732463423945

Congratulations! https://x.com/ChriSchmied/status/1858479873909534996

🎃👻 Frappy Halloween! 👻🎃 A captivating glimpse into a “haunted” sample 👀✨ Big thanks to Marie Bieck and Arbesa Saiti from the #LehmannLab for testing the FRAP laser on one of our #microscopes! 🔬🧪 #ScienceHalloween #ImageOfTheMonth

New project launched! 🚀 Researchers explore the role of #phosphoinositides (PIPs) in metabolic diseases. Learn more 👉 https://t.co/xA1cBaUstw or Wirkstoffradio podcast: https://t.co/XePML1RYGS @isas_Leibniz @Leibniz_DIfE @LeibnizWGL #PIPMet @VolkerHaucke

Let the peptide sunshine brighten your day! #Microscopic image shows the crystalline form of a #peptide that is part of occludin, a transmembrane #protein localized at tight junctions. 👏Scientific Image of the Month September by Roman Shobik (Lehmann lab).

The new work from Lange lab @NatureComms shows how we can use SMA/DIBMA to not only see associated lipids, but can estimate their binding & study activity of intramembrane proteases in these systems through collisional mixing! https://www.nature.com/articles/s41467-024-51989-0

New interaction network discovered in endocytosis! Team around @MillesSigrid used NMR spectroscopy to study the 600 unstructured amino acids of AP180, revealing a new interaction network crucial for neuronal signaling &endocytosis. Published @NatureComms https://t.co/CcqapzEwi7

New insights @HanSun_lab in collaboration with the Baukrowitz lab (University of Kiel), on phosphorylation of TREK channels could offer therapeutic potential for ischemia, epilepsy & depression, published @NatureComms More: https://t.co/7q8IoPX9PP Illustration: @BarthvanRossum

Happy to start working with new 1,2 GHz NMR spectrometer - perfect for precise analysis of complex biological systems like #proteinstructures ! Peter Schmieder, @HanSun_lab , Adam Lange, @MillesSigrid , Hartmut Oschkinat Read more 👇 https://t.co/EIx0fWmHO5

Diving deep into basic research @LNDWBerlin , guided tours @VolkerHaucke @GroupNazare @theliulab @daniel_roderer & Screening Unit and talk by Ralf Schülein @campusbuch #lndw24

Sunshine and science #lndw24 has started @campusbuch Visit us and get inspired! @VolkerHaucke @GroupNazare @daniel_roderer @theliulab & Screening Unit. Program https://t.co/ZssdYZpzbc

Auf dem @campusbuch begrüßen wir euch bereits ab 16 Uhr zur Langen Nacht der Wissenschaften. 👉 Programm https://t.co/hr0Lbnadnq #lndw24 https://t.co/lHX9omwh79

P5 technology from Christian Hackenberger group @PhosphorusFive enables a novel ADC now being tested in Phase I/IIa clinical trials.👏 Read more: https://t.co/ALmtOpxipl #Innovation #CancerTherapy #ADCs #basicresearch