🚀 AI vs. Thrombosis Experts: Who performs better? New study shows: AI models deliver patient education answers that are often rated better than experts — and perform similar in complex clinical cases. @nikola-vladic.bsky.social @jeanconnorsmd.bsky.social @jthjournal.bsky.social

🤖🩸 #ArtificialIntelligence in everyday clinical practice: A study by #MedUniVienna shows that language models sometimes provide better answers than experts when it comes to questions about #venousthromboembolism. ⬇️ 📰 Results in @jthjournal.bsky.social​​

ISTH is partnering with Inari, now a part of Stryker, for #WorldThrombosisDay 2025! Together we’re advancing #VTE care through a new educational offering: 🎧 The Role of Mechanical Thrombectomy in Transforming VTE Care Launching Oct 16 on the ISTH Pulse Podcast. 🔗 www.worldthrombosisday.org

JTH is proudly supports @worldthrombosisday.bsky.social! Show your commitment to patient safety and awareness this #WorldThrombosisDay on October 13. Share this graphic or create your own image using the WTD Design Hub: www.worldthrombosisday.org/poster-builder/ #WTDay25

The ISTH proudly recognizes Global #ITP Awareness Week 💜This year’s campaign theme, "Shining a light on ITP," underscores the importance of visibility and community engagement. #PaintThePlanetPurple #LightUp4ITP 🟣ISTH members: The ISTH offers educational resources about ITP here lnkd.in/debX39MC

1/ 📣 New risk calculator for stroke prediction in #AFib ♥️ Two #REGARDSStudy manuscripts in @jthjournal.bsky.social ♥️ One Identified biomarkers for breakthrough stroke ♥️ In the other we developed a new CHADS-VASc-Biomarkers score @samnotshort.bsky.social go.uvm.edu/strokecalc

@jthjournal.bsky.social commentary in the most recent issue about more VTE prevention is needed in pregnancy - www.jthjournal.org/article/S153... It will be interesting to see what the new UK 37a green top guidelines advise in the Autumn

💡Turn your exciting research into high-impact publications! Whether you presented at #ISTH2025 &/or have some other new & exciting science to share, watch this interview w/our editors & learn more about submitting to @ISTH.org @jthjournal.bsky.social or @rpth.bsky.social bit.ly/46TLcfk

📢📢NEW research from @jthjournal.bsky.social! Two new papers were released on stroke risk and prediction in #atrialfibrillation. Whether you’re a clinician or researcher, you won’t want to miss these insights. Visit jthjournal.org to explore this new research. #stroke #afib #af

Our webinar with Dr. Jean M. Connors has been rescheduled to August 1st! Don’t miss this opportunity to hear from a top expert in the field! #ISTH2025 #Hematology #MedicalEducation #ClinicalHematology @ash.hematology.org @isth.org @jthjournal.bsky.social @athnnews.bsky.social

📚Spotlight on ISTH publications at #ISTH2025: ✅ @rpth.bsky.social: As ISTH’s open-access, online-only journal, RPTH is drives innovation & accessibility in science. ✅ @jthjournal.bsky.social: JTH publishes peer-reviewed groundbreaking research, reviews & clinical guidance Learn more: bit.ly/4k5PbID

If you want to learn more about Factor XI inhibitors, check out this recent review article in @jthjournal.bsky.social pubmed.ncbi.nlm.nih.gov/39675564/

Global EHR-based study shows ~6% of children with CHD develop VTE within a year post-surgery, with a 25% recurrence rate. Most cases involved LE-DVT. Highlights need for targeted thromboprophylaxis strategies in this high-risk population. #PedsCardio #Thrombosis www.jthjournal.org/article/S153...

Amazing and thorough discussion on the ISTH Hemophilia Guidelines contents & methodology live at #ISTH2025 See this paper in JTHfor more deconstruction of the guidelines #hemophilia #hemesky www.jthjournal.org/article/S153...

Meta-analysis on GLP-1RA (vs. placebo) and VTE: 🔹 PE rates significantly lower 📉 🔹 VTE rates lower but not statistically significant 🔹 No difference in DVT 🔹 Study design matters: RCTs vs. observational data Accepted for publication in JTH! #ISTH2025 #VTE #GLP1RA #Thrombosis @jthjournal.bsky.social

The @rpth.bsky.social and @jthjournal.bsky.social Editors presented the Editors awards this afternoon, including this one to Daniel Steiner.

Corticosteroids remain the go-to for managing transaminitis post-valoctocogene roxaparvovec in hemophilia A. Early, reactive treatment may help preserve FVIII levels. #GeneTherapy #HemophiliaA #HemeSky www.jthjournal.org/article/S153...

Interesting discussion on high open access fees, increase of high quality papers from China & usage of Generative AI. More tools are needed #isth2025 @isth.org @jthjournal.bsky.social @rpth.bsky.social

And we're off #isth2025 EIC Ton Lisman @jthjournal.bsky.social introduces key points! Follow them on @linkedin.com

Considerations for use of generative AI in publication presented at the Publication Session #ISTH2025 @jthjournal.bsky.social

Find the @rpth.bsky.social and @jthjournal.bsky.social editors in PUB01 - The evolving landscape of academic publishing! 📍Room 151 A&B ⏰ 10:30-11:30 🗣️ @profmakris.bsky.social, Ton Lisman and Suzanne Cannegieter with host Donna DiMichele

🩺 In the PAUSE-2 pilot trial, perioperative management of DOACs in patients undergoing high-bleed-risk surgery or neuraxial procedures was found feasible. Both ASRA- and PAUSE-based strategies achieved similar pre-op DOAC levels, supporting a larger trial. www.jthjournal.org/article/S153...

Just in time for the #ISTH2025 congress! @ISTH.org releases its Updated Clinical Practice Guidelines on the Diagnosis and Treatment of TTP. Learn more ⬇️and if you are attending #ISTH2025, don't miss the Guidelines Session GG01 on Saturday at 09:30 (US ET) bit.ly/3G8zaUp

Blocking tubulin detyrosination via VASH1-SVBP inhibition enhances proplatelet formation & boosts platelet counts—no impact on function. A novel understanding of the megakaryocyte tubulin code beyond tubulin isotypes. #Platelet #HemeSky www.jthjournal.org/article/S153...

What are the barriers to recruitment and participation in RCTs evaluating postpartum thromboprophylaxis? This qualitative study reveals trust in providers, altruism, and risk perception as key motivators and barriers. Important insights for future trial design. www.jthjournal.org/article/S153...

Follow our #isth2025 updates and/or these great thrombosis & haemostasis people #hemesky @isth.org @jthjournal.bsky.social @rpth.bsky.social

How should women with AT deficiency be managed during pregnancy? This multicenter study shows that high-dose LMWH and peripartum AT concentrate may reduce venous thrombosis risk. www.jthjournal.org/article/S153...

New study uncovers a zebrafish-specific interaction between TPO receptor (zTpoR) and Mapk14a (p38 MAPKα), crucial for thrombocyte development. This direct interaction, absent in humans, regulates thrombocyte count and clotting via unique signaling. #zebrafish www.jthjournal.org/article/S153...

More #isth2025 #hemesky here

Explore the #June2025 issue of JTH! Highlights: cancer-linked SVT, GPVI malfunction in young platelets, DOAC failure in VTE, and device-induced thrombosis insights. 🩸 jthjournal.org #VTE #hematology

New data reveal a prothrombotic shift in cirrhosis: despite reduced plasmin generation, thrombin generation remains intact—creating a disbalance between coagulation and fibrinolysis. TG/PG ratio may be a novel marker of thrombotic risk. #cirrhosis #thrombosis www.jthjournal.org/article/S153...

And a bonus one too 🤗

🩸 In NSCLC patients starting chemo, elevated FXIa:AT and TAT levels predict VTE and mortality. A new biomarker-based score stratifies risk, offering a potential tool for early intervention. #NSCLC #VTE #oncology #thrombosis #HemeSky www.jthjournal.org/article/S153...

🧪 New findings challenge assumptions about young platelets: during stress thrombopoiesis, newly formed platelets show a transient defect in GPVI signaling. Full function appears to develop only after circulation time. #platelets #GPVI #hematology

🧪 Real-world study validates a new ADAMTS-13 assay: fast, reliable, and accurate for diagnosing and monitoring TTP. Strong performance at critical low activity levels makes it a valuable tool in clinical practice. #TTP #hematology #ADAMTS13 #labmedicine #MedSky www.jthjournal.org/article/S153...

🧪 This study uncovers a novel aging-related thrombosis mechanism: Rpl13a snoRNAs in red blood cells drive ROS and venous thrombosis by silencing peroxidasin via 2ʹ-O-methylation. Knocking out these snoRNAs reduced thrombi in aged mice. #thrombosis #hematology www.jthjournal.org/article/S153...

New insights into antiphospholipid syndrome: plasmin cleavage transforms β2GPI into a novel S-shape, increasing exposure to autoantibodies. This structural shift may explain enhanced immune reactivity and altered function. #APS #MedSky

⚠️ ISTH-SSC communication alert: Oral FXa inhibitors can interfere with heparin anti-Xa monitoring during therapy transitions. This may mislead anticoagulation management. This communication offers practical steps for UFH use. #anticoagulation www.jthjournal.org/article/S153...

🫀 This recent review article explores why thrombosis remains a major challenge in mechanical circulatory support. Device surface properties & flow dynamics drive clot risk—offering opportunities for safer designs. #biomaterials #cardiology www.jthjournal.org/article/S153...

In Impella-supported cardiogenic shock, discrepancies between anti-Xa and APTT during UFH therapy are common and linked to higher mortality—especially when paired with abnormal INR or low fibrinogen. #MedSky #Criticalcare #HemeSky www.jthjournal.org/article/S153...

For the first time in 16 years, ISTH is returning to the U.S. for an in-person Congress. As we prepare to welcome the world to Washington, D.C., we’re guided by our mission & appreciation for our community🌍 Read more @jthjournal.bsky.social: www.jthjournal.org/article/S1538-7836(25)00213-2/abstract

🧠 New network meta-analysis of 10,665 patients suggests dual antiplatelet therapy (aspirin + clopidogrel) may be the best option for minor stroke—more effective than aspirin or rt-PA, with lower bleeding and mortality risk. #stroke #neurology #DAPT #MedSky www.jthjournal.org/article/S153...

Are platelet antibodies clinically relevant? This large cohort study shows that anti-GPIIb/IIIa or anti-GPIb/IX antibodies is associated with lower platelet counts, especially when multiple GPs were targeted or antibody levels were high. #ITP #hematology #MedSky #platelets

All respiratory viral illnesses drive immunothrombosis. The more severe the illness, the more MACE you see. The relation between viral illnesses and MACE is causal. @jthjournal.bsky.social @isth.org www.jthjournal.org/article/S153...

🔬Are you ready to lead the next big conversation in thrombosis and hemostasis research? The ISTH Fundamental Research Workshop Grants are designed to support small, focused international meetings on cutting-edge topics. Up to $50,000 USD is available for each of three annual awards: bit.ly/4jOk2KL

Your 5 minute read for today 🤗

🚨Last chance to share your cutting-edge science! Late-breakthrough abstract submission for #ISTH2025 is OPEN. Deadline: May 14. This is your opportunity to present high-impact, late-breaking research on the world stage. 📖Read full guidelines and submit: www.isth2025.org/late-breakthrough

🫀 New study compares heparin vs. PPC coatings in VA-ECMO: heparin-coated circuits showed fewer thrombotic events and distinct thrombi composition. PPC circuits had higher VWF content. Findings highlight coating type matters in ECMO outcomes. #MedSky #cardiology www.jthjournal.org/article/S153...

🌟Ready to grow your network & level up your career? 🌟Interested in mentoring an #ISTHearlycareer to be the next star in #thrombosis & #hemostasis? Apply to the @ISTH.org Mentor-Mentee Match Program by July 31. You may even meet your match @ #ISTH2025! bit.ly/42rNLTz

In this post hoc analysis, treatment approaches following on-treatment recurrent VTE in cancer patients were found to be highly variable, and bleeding and recurrence risks remain high. 🔗