#miRNA family miR-29 inhibits #PINK1 -PRKN signaling via ATG9A Briana N. Markham, Chloe Ramnarine, Songeun Kim...Wolfdieter Springer & Fabienne C. Fiesel @mayoclinic.org #Parkinsons link.springer.com/article/10.1...

STIP1/HOP promotes the formation of cytotoxic α-synuclein #oligomers Benjamin S. Rutledge...Justin Legleiter, Martin L. Duennwald, Wing-Yiu Choy #alphasynuclein #synucleinopathies link.springer.com/article/10.1...

#ApoE expression across the CNS: Who, What, Where, When, and How (much)? Georgia L. Nolt, Chloe C. Lucido, Lily M. Smith, Lance A. Johnson @uksbcoa.bsky.social @universityofky.bsky.social #AlzheimersDisease link.springer.com/article/10.1...

#Glial-specific and inducible full body C3 deficiency does not affect #amyloid pathology in the AppNL−G−F mouse model of #AlzheimersDisease Pieter Dujardin, Joyce Foroozandeh, Roselien Verhaegen...Roosmarijn E. Vandenbroucke link.springer.com/article/10.1...

Toward #nanomedicine -enabled RNA therapeutics for #AlzheimersDisease Goknur Kara & Sonia Villapol @svillapol.bsky.social link.springer.com/article/10.1...

The mechanism of actions of #caffeine in #AlzheimersDisease: a systematic review of preclinical studies Ying Zhai, Thomas Nevian, David P. Finn, Andrea Kwakowsky @uniofgalway.bsky.social link.springer.com/article/10.1...

#Neuroinflammatory stress preferentially impacts synaptic MAPK signaling and #mitochondria in excitatory neurons Claudia Espinosa-Garcia, Upasna Srivastava, Prateek Kumar...Srikant Rangaraju #proteomics #AlzheimersDisease link.springer.com/article/10.1...

Female-specific Cx3cr1-driven regulation of #ALS and #Alzheimer’s risk genes in #tauopathy Ari Sudwarts & Gopal Thinakaran @thinakaran.bsky.social #microglia #transcriptome link.springer.com/article/10.1...

Pyk2 plays a critical role in #synaptic dysfunction during the early stages of #AlzheimersDisease Quentin Rodriguez, Floriane Payet, Karina Vargas-Baron...Alain Buisson #hippocampus #amyloid link.springer.com/article/10.1...

Spilling the T: #Tcells in #tauopathy mechanisms, disease progression, and therapeutic horizons Megan E. Bosch & Jason D. Ulrich link.springer.com/article/10.1...

#Lysosomal protease-mediated APP degradation is pH-dependent, mutation-sensitive, and facilitates tau #proteolysis Caroline Ackley...Paul J. Sampognaro, Aimee W. Kao @ucsfmac.bsky.social @ucsanfrancisco.bsky.social #amyloid #AlzheimersDisease #autophagy link.springer.com/article/10.1...

#Genetic evidence supports therapeutic modulation of #progranulin levels in #AlzheimersDisease Chloe Robins, John D. Eicher, Jimmy Liu...Chun-Fang Xu @GSK link.springer.com/article/10.1...

Differential downstream signaling in #microglia lacking #Alzheimers -related #TREM2 or its adaptor TYROBP/DAP12 Gabriela E. Farias Quipildor...Stephen R. J. Salton, Michelle E. Ehrlich link.springer.com/article/10.1...

Correction: Adoptive NK cell transfer confers neuroprotection by attenuating neuroinflammation and alpha-synuclein pathology in a mouse model of synucleinopathy link.springer.com/article/10.1...

GPCRs with #genetic associations to #AlzheimersDisease traits: an underdeveloped target class for disease progression Jessica Karson, Laurent Chesnel, Susan Acton link.springer.com/article/10.1...

Development of #cannabinoid-based therapies for #Parkinsons disease: emphasis on targeting cannabinoid receptors as CB2, PPAR-γ and GPR55 receptors Sonia Burgaz, Santiago Rodríguez-Carreiro...Javier Fernández-Ruiz #endocannabinoids link.springer.com/article/10.1...

Divergent #TDP43-regulated and TDP43-independent cryptic splicing in the cortex and #spinalcord Dwight F. Newton, Rena Yang, Johnny Gutierrez...Brad A. Friedman #ALS #AmyotrophicLateralSclerosis #FrontotemporalDementia link.springer.com/article/10.1...

C3 lowering in adult APP KI mice rescues synapses and spares cognitive decline Brijendra Singh, Andre F. Batista, Emma T. Spooner...Cynthia A. Lemere @harvardmed.bsky.social #AlzheimersDisease #complement #amyloid #neuroinflammation link.springer.com/article/10.1...

Global C3 lowering in adulthood protects against hippocampal dysfunction and #cognitiveimpairment in aged mice Andre F. Batista, Jessey Presumey, Brijendra Singh...Cynthia A. Lemere @harvardmed.bsky.social #complement #neurodegeneration link.springer.com/article/10.1...

Genetics of #PLCG2 expression and splicing relative to #AlzheimersDisease risk Andrew K. Turner, Kennedy Dotson, Qi Qiao...Steven Estus @uksbcoa.bsky.social @universityofky.bsky.social #genetics link.springer.com/article/10.1...

Serum #metabolomic - #lipidomic signatures track long-term neurological performance in #MultipleSclerosis Rose Noroozi, Hui-Hsin Tsai, Ketian Yu...Kathryn C. Fitzgerald @hopkinsmedicine.bsky.social #biomarkers link.springer.com/article/10.1...

Adoptive NK cell transfer confers #neuroprotection by attenuating #neuroinflammation and #alphasynuclein pathology in a mouse model of #synucleinopathy Adetutu Adebowale, Jung Ha Byun, Jaegwon Chung..Jae-Kyung Lee @universityofga.bsky.social #Parkinsons link.springer.com/article/10.1...

Emerging roles of the #ciliary-#mitochondrial axis in cellular homeostasis and neuroprotection Emiko Miller, Peter Bambakidis, Phoebe Templin, Bindu D. Paul & Andrew A. Pieper #neurodegeneration #AlzheimersDisease link.springer.com/article/10.1...

"Early-Onset Alzheimer’s with Loss of Presenilin-1?" www.alzforum.org/news/researc...

'The curious case of a heterozygous loss-of-function #PSEN1 variant associated with early-onset #AlzheimersDisease' Inmaculada Sanjuan-Ruiz, Lutgarde Serneels, Katleen Craessaerts...Bart De Strooper @leuvenbrainins.bsky.social @ukdri.ac.uk @viblifesciences.bsky.social bit.ly/3L0QhK6

Dose-ranging and further therapeutic evaluation of a bicistronic humanized TrkB-BDNF #genetherapy for #glaucoma in rodents Andrew Osborne, Tasneem Z. Khatib, Michael Whitehead...Keith R. Martin‬ @cambridge.org mnadvances.biomedcentral.com/articles/10....

Uncovering plaque- #glia niches in human #AlzheimersDisease brains using spatial #transcriptomics Denis R. Avey, Bernard Ng, Ricardo A. Vialle...Yanling Wang @rushalzheimers.bsky.social #glia mnadvances.biomedcentral.com/articles/10....

"A new dawn in neurodegeneration research: MN advances" Our Editor-in-Chief, Dr. Guojun Bu, introduces MN Advances in this inaugural piece — marking the launch of our very first MN Advances publication! Check it out here: bit.ly/4cJ2pZN

👋✨ Introducing Molecular Neurodegeneration Advances! Building on the success of Molecular Neurodegeneration, MN Advances is an open-access peer-reviewed journal aiming to encompass a wider range of neurodegen diseases while maintaining our commitment to scientific excellence & rigorous peer review