Pirto v venetoclax in R/R WM #ASH25 - 91 pts: 64 VEN - MV model:⬇️PFS w/ ven if TP53mut;⬇️MRR & PFS w/ pirto if CXCR4mut - no diff in MRR or PFS between pirto & VEN - transition from BTKi to VEN = 62% IgM rebound (didn't happen w/ pirto) Genetic-based tx decisions in WM! #lymsm

A time toxicity analysis of CAR-T in NHL by Trotier et al. from #ASH25 (using claims data) found a 1-year median of 52 contact days, very similar to our multicenter study. Very promising that we can use claims data to generate these time toxicity data. #lymsm cc @uduranimd.bsky.social

In our study of real-world survival & time toxicity of CAR-T vs BsAb in R/R FL, we found that CAR-T resulted in superior PFS but more time toxicity, with no difference in OS. Over first year, 51-64 physical healthcare contact days with CAR-T vs 36-38 with BsAb. #lymsm www.vumedi.com/video/ash-20...

CU Cancer Center member Ajay Major (@majorajay.bsky.social), MD, MBA, led a study of more than 25,000 long-term childhood cancer survivors, to learn more about their rates of colorectal cancer and what their doctors can do about it ⬇️ https://bit.ly/3MkDl2t

At #ASH25, we presented our patient-reported time toxicity study in 120 pts w/ R/R FL & DLBCL on mosun, glofi & epcor. Mosun & glofi w/⬇️all-cause healthcare visits & hours spent on cancer-related care in past 30 days v epcor. More details in this #thread. #lymsm www.sciencedirect.com/science/arti...

Announcing my #ASHNewsDaily Golden Globule award picks for @ash.hematology.org #ASH25! I gave my awards to the best (shocker) patient-reported outcomes abstracts, including quality of life studies from trials and in real-world practice. #MajorPROsASH ashpublications.org/ashnewsdaily...

Thanks for all the great memories, my #ASH25 friends! Stay in touch, and looking forward to seeing your new abstracts at #ASH26. cc @ash.hematology.org

Our budding PRO researcher Dr. Hofmeister @cuinternalmed.bsky.social in the @cuhematology.bsky.social Major Lab presented her work on quality of life in CTCL at the @ash.hematology.org #ASH25 Annual Meeting. Thread below with our study findings. 🧵 #lymsm

The L-THORs (Lymphoma Translational Health Outcomes Researchers) assemble at #ASH25, presenting work in patient-reported outcomes and time toxicity! 🎉 #lymsm cc @ash.hematology.org

Twins looking sharp!! #ASH25

Hematology twins! @mazietsangmd.bsky.social #ASH25 #fASHion cc @ash.hematology.org

If you want a preview of the CLL17 plenary later today, read my #ASHNewsDaily article where I interview Dr. Othman Al-Sawaf about the study results and time-limited versus indefinite treatment strategies in 1L CLL. #ASH25 #leusm ashpublications.org/ashnewsdaily... @ash.hematology.org

Hey #ASH25: check out my #ASHNewsDaily interviews with Drs. Ferdinandus & Herrera about the HD21 & S1826 trials setting new standards for cHL, and with Drs. Ahmed & Falchi about TRANSCEND & EPCORE FL-1 maximizing remissions in FL. #lymsm ashpublications.org/ashnewsdaily... @ash.hematology.org

Now online: my #ASHNewsDaily article interviewing presenters at this afternoon's 'Innovative Models of Lymphoma' Scientific Program Session (2pm, OCCC, West Hall E2) about the future of lymphoma-mimicking organoids, xenografts, and mice. #ASH25 @ash.hematology.org ashpublications.org/ashnewsdaily...

Happy #ASH25 day! Check out all of this year's #MajorPROsASH, the top 20 best patient-reported outcomes & quality of life abstracts from this year's @ash.hematology.org meeting. Check out the hashtag for details on all the abstracts: bsky.app/hashtag/Majo...

FD mosun in 1L HTB FL #ASH25 - 103 pts - 46/68 elected for maintenance mosun + 1 yr - ORR 87% (CR 64%), 1-yr PFS 86% - 33 d/c'd (mostly d/t PD) - 78% infections, 5 pts with G5 AEs! Need longer f/u & more CRS data. Seems somewhat toxic. #lymsm

5-yr f/u pirto R/R WM #ASH25 - 80 pts, 89% MYD88mut, 22% CXCR4mut, 79% prior cBTKi - ORR 83%, MRR 73%, mDOR 42 mo - mPFS 3 yr, 3-yr OS 67% - RR & PFS similar w/ prior cBTKi Great outcomes in heavily-pretx. Combo w/ pirto (like ven) being explored for FD tx. #lymsm

Pirto+ven R/R WM/LPL #ASH25 - 38 pts, 29 completed 6 cycles (total 24) - ORR 100%, VGPR/CR 56% - lower RR if CXCR4mut, TP53mut, prior cBTKi - 12-mo PFS 94% - MYD88wt pts (n = 2) w/ early PD Great all oral option for MYD88mut R/R WM. #lymsm #wmsm

DRC+/-bortezomib randomized 1L WM #ASH25 - 202 pts - mPFS 57 mos (B-DRC) vs 50 mos (DRC) - no diff TTNT or OS (5-yr OS 89-91%) - much more PN in B arm - 4-mo cum incidence of first response 73% B-DRC (vs 61% DRC) Outcomes very similar to BR. #lymsm

Going to skip pre-tweeting these #ASH25 abstracts because I review them (and interview the presenters!) in my #ASHNewsDaily article coming out on Sunday! #lymsm

1 – #MajorPROsASH – 709 Karmali Liso-cel in R/R MZL: early deterioration in multiple QoL domains by D15. However, by 3 months after liso-cel, QoL rebounds above pre-CAR baseline & sustained until 18 months after liso-cel! Now FDA approved w/ meaningful QoL benefits. #lymsm #ASH25 @ash.hematology.org

Right on the eve of @ash.hematology.org #ASH25: liso-cel approved for R/R MZL after 2+ prior lines of therapy! #lymsm #tcellrx www.fda.gov/drugs/resour...

2 – #MajorPROsASH – 5509 Budde Mosun-pola w/ sig prolonged TTD of phys fxn, #lymsm related sx, and neuropathy vs R-GemOx. Fatigue improved with mosun-pola (no change R-GemOx). Pain improved faster w/ mosun-pola. QoL & PFS improvements in palliative setting. #ASH25 @ash.hematology.org

3 – #MajorPROsASH – 5370 Linton EPCORE FL-1 PROs: Functional QOL + side effect burden initially worsens w/ epco+R2, recovers by C5D1. Otherwise no clinically meaningful worsening in QoL by EOT w/ epco+R2 or R2. Can counsel pts about dynamic QoL changes over time. #ASH25 #lymsm @ash.hematology.org

4 – #MajorPROsASH – 5362 Frustaci Prospective frailty & PROs WM: Nearly all pts w/ at least 1 impaired geri domain. Functional/psychological status & lack of social support significantly associated with inferior QoL. PRO + geri assessment can stratify frailty in WM. #ASH25 #lymsm @ash.hematology.org

5 – #MajorPROsASH – 522 Lapen Novel PRO tool for RT in CTCL (Skindex-16 + PRO-CTCAE + EORTC QLQ-C30). Improved QoL 1 month post RT & sustained thru 6 months. TSEBT w/ better QoL improvements vs focal RT. Severe fatigue during RT improved by 1 month. RT improves QoL! #lymsm #ASH25 @ash.hematology.org

6 – #MajorPROsASH – 2738 Davison S1826: N-AVD w/ worse fatigue at EOT and less neuropathy at 1 yr in all ages. BV-AVD w/ worse neuropathy only in adults. Global QoL better for adults on N-AVD, but no diff in adolescents. PROs across whole age spectrum can be collected! #lymsm @ash.hematology.org

7 – #MajorPROsASH – 138 Efficace Frailty + PRO model RRMM: patient-reported physical functioning (PF) is associated with OS in multivariable model, including IMWG frailty index. Adding PF to frailty model improved fit vs frail. Future for PROs in tx decision-making! #mmsm @ash.hematology.org

8 – #MajorPROsASH – 2263 Mai Isa-RVd v Rvd in NDMM: Adding isa = improved fatigue, pain, and future perspectives. Both study arms: better phys/emotional functioning. Similar to D-RVd data; quads can improve QoL in #mmsm. #ASH25 @ash.hematology.org

RSV after CAR-T #ASH25 - 667 pts s/p CAR: 38 RSV infections - 74% infx >D100 (median 8 mo) - 71% URTI, 29% LRTI: 8 G3 cases (all got ribavirin +/- steroids/IVIG & survived) - LRTI: older, lower ALC & CD4 Targeted vaccination strategies? #lymsm #tcellrx

CD19 CAR in patients with HIV #ASH25 - 35 pts (control cohort 135 HIV-), 91% DLBCL, 97% axi-cel - less CRS (no diff ICANS) & more infx in HIV+ cohort - ORR/CR and OS worse if HIV+, no diff PFS or TRM - 2-yr PFS 28% & OS 37% Adverse prognosis driven by disease features. #lymsm

Fun #ASH25 abstract: CD19 CAR in CD19-negative LBCL - 211 pts: 18% CD19neg before CAR (all 3L+) - no diff CRS, much less ICANS if CD19neg - no diff CR/ORR/PFS/OS between CD19+ and CD19- Tumor heterogeneity?! #lymsm #tcellrx

Rapid dose escalation glofi/epco #ASH25 - 30 pts w rapid escalation - median time to 1st full dose: 6 d epco, 14 d glofi - 16 CRS (2 G3), 7 ICANS (2 G3-4) - More CRS/ICANS than std escalation pts in CUBIC consortium registry. Looking forward to future subgroup analysis. #lymsm

tFL vs de novo LBCL post-CAR outcomes #ASH25 - 272 pts, 33% tFL, all axi-cel - mPFS: tFL 25 mo, dnLBCL 6 mo - mOS: tFL NR, dnLBCL 17 mo - worse PFS/OS if concurrent FL/DLBCL or HT w/i 12 mo Much better post-axi-cel outcomes for tFL, but high-risk subgroups persist. #lymsm

Super proud of Dr. Elisa Hofmeister @cuinternalmed.bsky.social (& #ASH25 Abstract Achievement Award recipient!) for her study of PROs in CTCL. She found that emotional wellbeing is profoundly impaired regardless of stage, tx type, or physical symptoms. #lymsm submit.hematology.org/program/pres...

Epco+ritux 1L HTB FL #ASH25 - 35 pts, 29% bulky, 57% FLIPI 3+ - ORR 97% (CR 91%), 1 non-responder had HT - 9-mo PFS 97% - 43% CRS (all G1-2), 54% infx (9% G3) - 4 pts d/c'd d/t low-grade infx R prephase⬇️CRS risk w/ epco SUD. 9 cycles tx total, w/ plan for q4w for C4-C9. #lymsm

Mosun+zanu 1L HTB FL #ASH25 - 45 pts, 40% bulky, 18% FLIPI 3+ - 56% CRS (all G1-2), 29% infx - n=1 G5 EBV-HLH during C1 - ORR 85% (CR 74%), 2 pts w/ PD Need longer f/u (only 4 mos). Time-limited strategy & could be for non-CIT candidates. #lymsm

9 – #MajorPROsASH – 4029 @sagarlonialmd.bsky.social DREAMM-7 BVd v DVd: 1/3 new ocular AEs w/ belamaf. However, global QoL & functioning were maintained (& comparable to DVd) despite ocular AEs. BVd also w/ longer TTD phys fxn & #mmsm related sx. Great PRO data to give PFS context. #ASH25

10 – #MajorPROsASH – 406 Berenson Remote symptom monitoring (RSM) by SMS #mmsm: >87% PRO completion rates, <3 minutes per survey. 44% of symptom alerts were acted upon. Scalable real-time RSM is holy grail in real-world PROs to improve tx tolerability (& survival). #ASH25 @ash.hematology.org

11 – #MajorPROsASH – 540 Hermans Mim8 (F8 BsAb mimetic) ppx #hemophilia A: clinically-meaningful improvements in PRO-assessed treatment burden, physical fxn & joint pain at 1 year. PROs similar between qweek & qmonth dosing. >88% preferred Mim8 over previous on-demand tx. #ASH25 @ash.hematology.org

Vaccine humoral immunity pre/post CD19/BCMA CAR #ASH25 - of 509 pts, 43 received vaccines after CAR - MM pts had lower vaccine titers vs NHL - revaccination significantly increased post-CAR titers Vaccines at least 6 mos after CAR appear to remobilize memory B cells. #lymsm #mmsm

Symptom-based PFS CLL/SLL #ASH25 - 606 pts in ALPINE (zanu v ibru) - longitudinal fatigue, insomnia, N/V associated with increased risk of PD (regardless of BTKi) - zanu: lower odds of symptom worsening vs ibrutinib More trial data demonstrating prognostic value of PROs! #leusm #lymsm

PIV vs CVC 1L anthracycline chemo #lymsm #ASH25 - 1414 pts: 50% CVC (79% port, 22% PICC) - extravasation: 1 CVC, 2 PIV - no diff in induration, phlebitis, VTE, erythema between CVC & PIV - however, more pain/tenderness & infiltration w/ PIV Which centers use PIV for R-CHOP/ABVD? #oncsky

12 – #MajorPROsASH – 949 @AustinKulasekar Danicopan add-on tx in PNH: significant improvements in Hgb, transfusion independence, and PRO-assessed fatigue. Younger & older pts had better fatigue w/ danicopan (no fatigue changes in placebo arm). Can improve QoL w/ add-on tx! #ASH25 @ash.hematology.org

13 – #MajorPROsASH – 614 Anishchenko EPO + hydroxyurea in #sicklecell disease: Hgb gain of ~3 g/dL plus improvements in pain, physical/role functioning, fatigue & mental health. Pilot study in US & Nigeria with provocative finding that EPO may reduce pain in #SCD. #ASH25 @ash.hematology.org

14 – #MajorPROsASH – 4278 Guilcher Children & AYA pts w/ #sicklecell disease receiving alloSCT: substantial QoL improvements and low decisional regret up to 3 yrs after allo. Study supports shared decision-making in #SCD that includes long-term⬆️QoL outcomes. #bmtsm #ASH25 @ash.hematology.org

15 – #MajorPROsASH – 4682 Kelley Single-dose IV ferric derisomaltose in pregnancy: Hgb improvement at 6 wks post-partum, as well as significant improvements in fatigue & depression PROs. Critically important trial in pregnancy that supports QoL benefits of IV iron. #ASH25 #obgyn @ash.hematology.org

Tx preferences in Waldenstrom #ASH25 - 1455 pts, internatl cohort - response duration & avoidance of temporary severe toxicity were highest importance - pts favored oral therapy at home (vs infusions) and fixed-duration over indefinite therapy Need FD oral (combo?) regimens. #lymsm

Impact of IVIG on post-CAR survival #ASH25 - 430 pts, most LBCL & axicel - low IgA at 1 & 3 mos = increased NRM at all timepoints - low baseline IgM = worse PFS/OS - 20% got IVIG: no effect on NRM! No impact of IgG on survival! Provocative & supports selective use of IVIG. #lymsm #tcellrx

Split-dose RCHOP frail/old DLBCL @prekallikrein.bsky.social #ASH25 - 50% CHOP D1+15/28D - 26 pts, med age 80, all IPI 3+, 48% impaired IADLs - EOT CR 65%; 8 pts were uMRD/PET- and only got 4C total - 18-mo PFS 58%, OS 67% - 2 pts NRM Very frail cohort; outcomes vs mini-CHOP? #lymsm #gerionc