New preprint! The same TFs can drive distinct regulatory programs depending on where they bind.
 TSS → rapid stress responses
 Intronic & upstream → cell-type programs
 Enhancer-like CRMs → embryo/meristem programs
 Coding-sequence binding → repression www.biorxiv.org/content/10.6...

our new preprint is out! if a transcription factor binds near a gene, does it matter exactly where? keep an eye out for a 🧵soon!

Sequencing methods 🧬 have come a long way from census counts 🔢 to assembling genomes and understanding the functions 🧪 of bacteria and viruses. New review by @jgi.doe.gov's Gitta Szabó, @emileyeloe-fadrosh.bsky.social, Tanja Woyke with @jeffinerca.bsky.social www.nature.com/articles/s41...

How do populations maintain an evolutionary memory? I am happy to share that our work with Dmitri Petrov @petrovadmitri.bsky.social, Paul Schmidt, and colleagues on dominance reversal and stabilization of insecticide resistance in changing environments over time is now published at Nature EE.

Do YOU use data from across multiple sources? (See list in link below) We want to know: ✅HOW you gather comprehensive data for the same sample; ✅WHERE you look; and ✅WHAT OBSTACLES you face Sign up by 8/31 to share: jointgeno.me/UserResearch2025 @berkeleylab.lbl.gov @nigelmouncey.bsky.social

Postdoc opportunity with @tomasbruna.bsky.social here at @jgi.doe.gov @berkeleylab.lbl.gov: Develop, benchmark, and apply Plant Genomic Language Models (gLMs) 🌿🧬💻 jobs.lbl.gov/jobs/computa... #AI #PlantGenomics #gLMs #Postdoc

these are all real DAP-seq peaks! specifically, peaks in the promoter of SWEET11 (a sugar transport gene) and its orthologs across 10 plant species the darker colored peaks are binding sites for transcription factors that have maintained regulation of SWEET11 across 100+M years of plant evolution

If you are interested in using DAPseq for your plant, algal, fungal or microbial genomes, consider applying to one of @jgi.doe.gov's user programs: jgi.doe.gov/work-with-us...

The Sudmant lab at UC Berkeley is seeking a postdoc to work on a fully funded NIH project to understand differences in DNA repair and somatic mutation across the primate tree of life. Please spread widely to those who may be interested aprecruit.berkeley.edu/JPF05052

August’s Nature Plants cover story shows how we integrated large-scale multiDAP and snRNA data to reveal drivers of cell type identity and evolution in flowering plants. www.nature.com/nplants/volu... We packed a lot into this paper! Here’s a single-cell spin on what we found:

Excited to share a new preprint w/ the Sonnenberg lab, led by Matt Carter, @zzzhiru.bsky.social & @mattolm.bsky.social. We analyzed the microbiomes of two non-industrialized populations from opposite sides of the globe to try to reconstruct the recent evolutionary history of our gut microbiota.

I am seeking a postdoc for my group at UCLA. We work at the intersection of population genetics x microbiome (garud.eeb.ucla.edu). If interested, please message me!

How is functional variation at large-effect loci maintained in natural populations? Thrilled to share our work showing how beneficial dominance reversal helps fruit flies maintain a resistance polymorphism as selection varies in their environment! A thread 🧵 1/n www.biorxiv.org/content/10.1...

The Dark Energy Spectroscopic Instrument (DESI) scientists mapped how nearly 6 million galaxies cluster across 11 billion years of cosmic history. Their observations line up with what Einstein's theory of general relativity predicts. 🧪 newscenter.lbl.gov/2024/11/19/n...

Hi friends new and old! I study how microbes interact and evolve in complex communities like the human gut microbiome.🦠🧬💩 I'm thrilled to share that I'm starting a lab at UC Irvine in April 2025 and am recruiting at all levels - please spread the word! kxuelab.com More about my work below...🧵1/n