Our study in @JAMAPsych ja.ma/4lVx1eu Using 🧬 we found that disruptions in #energy pathways link to specific #MDD symptoms (⬆️ appetite & sleep). This suggests a #depression profile linked to #metabolic risk, opening doors to targeted treatments. #metabolicpsychiatry

🚨 Preprint Alert 🚨 "Major depression and atherosclerotic disease: linking shared genetics to pathways in blood, brain, heart, and atherosclerotic plaques. " 🧠🫀🩸 The title says it all. Great collaboration with @swvanderlaan.bsky.social . 📄 Read it here: bit.ly/4eTM8T2

In May 2024, I joined an inspiring week at the Ernst Strüngmann Forum on #Metabolic #Neuropsychiatry. Our first outcome is now in Nature Mental Health: 🧠 A Perspective on energy metabolism in psychiatric disorders 🔗 www.nature.com/articles/s44... More to come in an upcoming volume—stay tuned!

Nice reminder of our #PNIRS2025 symposium. @eimearfoley.bsky.social, Naoise Mac Giollabhui, @dpmoriarity.bsky.social (in cross-Atlantic telepathic connection) and I will wait for you tomorrow morning!

Looking forward to this! If you're attending #PNIRS2025 be sure to come to our session (Symposia 4) on Wednesday morning and say hello 👋 @ymilaneschi.bsky.social @dpmoriarity.bsky.social @uob-ieu.bsky.social

Looking forward to connecting with colleagues at #PNIRS2025 in Bordeaux 🇫🇷. Don't miss our symposium "Dissecting Depression Heterogeneity along Immuno-Metabolic Pathways: Triangulating Evidence from Hierarchical-Phenotyping, Experimental and Genomic Methods" Time & Outline of the symposium ⬇️

Our new study in Translational Psychiatry showed that acylcarnitines (involved in mitochondrial #energy production) were linked to the presence+severity of #depression. Bioenergetic pathways may open new avenues in psychiatry #MetabolicPsychiatry check the paper ➡️: rdcu.be/eaWoN

🔬 What is Immuno-metabolic Depression? "Recognizing immune-metabolic mechanisms could be a relevant treatment target for part of the depressed population opens the doors to personalised psychiatry.” Read more: 🔗 https://buff.ly/3WRwYpK #MentalHealthResearch #DepressionResearch

Countdown on for the annual @pnirs.bsky.social meeting in Bordeaux #PNIRS2025 . Very excited for our member sponsored symposium (June 11) with @eimearfoley.bsky.social and @dpmoriarity.bsky.social on #depression heterogeneity and #immunometabolic mechanisms See you in 🇫🇷

New collaboration published in @brainbehavimm.bsky.social Analyses leveraging #genetic data highlighted the potential role of #metabolic alterations (e.g., dyslipidemia, dysglycemia) as mechanisms connecting #childhood maltreatment with psychiatric + somatic #multimorbidity. doi.org/10.1016/j.bb...

1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in @cellpress.bsky.social. www.cell.com/cell/fulltex... A thread 🧵:

"Immuno-metabolic #depression: from concept to implementation". Our new collaborative review is out in THE LANCET Regional Health - Europe. We reflected on the current standing of the immuno-metabolic depression concept and its potential value for clinical implementation bit.ly/4iAlVdL #openaccess

It was a pleasure to contribute to @thementalelf.bsky.social. In my piece, I discuss findings from a recent study by Spiller et al. (JAMA Psychiatry) on the heterogeneity of symptom presentation in mental disorder diagnoses.