Happy to share our @chemicalscience.rsc.org paper where we extract a SAR model from HT crystallographic readouts of fragment elaborations in crude reaction mixtures! Thanks to @kate-fieseler.bsky.social for co-writing and @philbiggin.bsky.social! doi.org/10.1039/D5SC... #MyFirstChemSci #FBDD #D2B

Congratulations @haroldgrosjean.bsky.social and @kate-fieseler.bsky.social on their paper explaining how to extract SAR data from throughput crystallographic evaluation of fragment elaborations in crude reaction mixtures. Awesome work! pubs.rsc.org/en/content/a...

🚨New preprint We extract structure–activity relationships (xSAR) directly from HT crystallography of crude reaction mixtures ⚡No hit resynthesis = faster DMTA 📄 doi.org/10.26434/che... @oxfordbiochemistry.bsky.social @diamondlightsource.bsky.social @opig.stats.ox.ac.uk @philbiggin.bsky.social #FBDD

🚨 Binding-Site Purification of Actives 🦾 With robotic chemistry, automated QC & HT crystallography, we skip purification for faster, greener, cheaper SAR and DMTA-cycles! 🔗 doi.org/10.1002/anie... Thanks to @diamondlightsource.bsky.social @oxfordbiochemistry.bsky.social & co!

Congratulations to Harold Grosjean, Anthony Aimon, Storm Hassell-Hart and Warren Thompson, on their latest work appearing in @angewandtechemie.bsky.social, where small-molecule binders can be extracted directly from crude-reaction mixtures - cool! onlinelibrary.wiley.com/doi/10.1002/...