John Witte (@johnwitte.bsky.social)

Allele Frequencies at Recessive Disease Genes are Mainly Determined by Pleiotropic Effects in Heterozygotes The classic theory of mutation-selection balance predicts the equilibrium frequency of genetic variation under negative selection. The model predicts a simple relationship between the total frequency ... https://www.biorxiv.org/content/10.64898/2025.12.05.692665v1