Today, I’m grateful that I can finally share Briana Lino’s @blino237.bsky.social work on engineering eukaryotic release factor 1 (eRF1) for enhanced noncanonical amino acid incorporation. I highlight some key findings in this thread (1/n). www.biorxiv.org/content/10.1...

Our recent review article describes how high throughput screening pushes genetic code manipulation toward: 1. Efficient biosynthesis of proteins containing noncanonical amino acids 2. Applications of chemically expanded proteins in therapeutics + basic research (1/2) pubs.acs.org/doi/abs/10.1...