Translucence Biosystems
@translucencebio.bsky.social
š¤ 28
š„ 17
š 250
Leaders in next-generation 3D histology and AI-powered quantification for intact biological samples
Happy
#FluorescenceFriday
! Today we are excited to share this video which shows a cleared mouse brain hemisphere following depletion of endogenous microglia and transplantation of human cells (magenta).
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7 days ago
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We had a great time at AD/PD⢠2026 in
#Copenhagen
, engaging with researchers driving advances in neurodegenerative disease research!
9 days ago
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Today, we are presenting two posters at AD/PD⢠2026. Poster #3404 examines whole-brain measurement of plaques, microglia, α-synuclein, and tyrosine hydroxylase in AD and PD model mice using tissue clearing, light sheet imaging, and AI-powered quantification.
15 days ago
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Today marks the start of AD/PD⢠2026 in
#Copenhagen
! We are excited to join the community this week to discuss new approaches for measuring CNS disease pathology and therapeutic distribution across intact brain tissue.
17 days ago
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We are excited to announce our second poster that we will be presenting at AD/PD⢠2026!
21 days ago
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We are excited to announce our first poster that we will be presenting at AD/PD⢠2026!
23 days ago
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For the first Fluorescence Friday of the month, we want to take a moment to recognize Brain Awareness Month and celebrate the researchers and technologies helping us better understand the brain in health and disease.
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28 days ago
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Join CEO, Damian Wheeler, and Director of Products and Business Development, Nathaniel Guanzon, at
#ADPD2026
as they present recent work applying our brain-wide measurement techniques to the evaluation of CNS therapeutics and disease pathology in intact tissue.
about 1 month ago
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This dataset shows α-synuclein staining (green) in a cleared mouse brain following direct PFF injection. The video reveals the distribution of α-synuclein fibrils and cell bodies at cellular resolution across the intact brain.
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about 1 month ago
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This dataset shows alpha-synuclein staining in a cleared mouse brain following direct PFF injection. The video reveals the distribution of alpha-synuclein fibrils and nuclei at cellular resolution across the intact brain.
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about 1 month ago
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Your first look at our newest tissue clearing technology, TB.Clearā¢! Ā Tissue clearing has transformed how we study intact biological systems, but many solvent-based methods (including widely used protocols like iDISCO+) can quench endogenous fluorescence.
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about 1 month ago
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Today was the first day of the FLAIR workshop! Are you or someone you know attending? Be sure to stop by our booth between all of the amazing talks and demos happening between today and Thursday! We are excited to discuss the ways we can support your research.
3 months ago
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Weāre excited to attend and sponsor the Fluorescence Advanced Imaging Research (FLAIR) Workshop! FLAIR brings together the legacy Laboratory for Fluorescence Dynamics (LFD) and Advanced Imaging Methods (AIM) workshops.
3 months ago
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Happy New Year from Translucence Biosystems! Weāre excited to continue helping researchers turn intact tissues into actionable insights. Wishing you a year of strong data, smooth experiments, and big breakthroughs.
3 months ago
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Happy Holidays from Translucence Biosystems!
3 months ago
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Happy Thanksgiving! We are thankful for all of our amazing clients, colleagues, and collaborators! Wishing everyone a safe and happy holiday. P.S It's a great time of year to try out the new Translucence Biosystems Turkey Tissue Clearing Protocol š
4 months ago
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We had a great time at the Society for Neuroscience (SfN) Annual Meeting in San Diego last week! It was great connecting with friends and partners in the neuroscience community.
4 months ago
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Day 3 of
#Neuroscience2025
! Join us for our final poster highlighting collaborative work with Innopsys on āHigh Throughput Immunohistochemistry Imaging and Quantification Using PMT-Generated Images and Cloud-Based ML-Powered Softwareā (PSTR198.22) from 8 AM - 12 PM.
5 months ago
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We're presenting three posters today from 1-5 PM covering brain-wide quantification of AD pathology (PSTR111.19), tools for mapping neuronal activity with Npas4 and cFos (PSTR143.04), and brain-wide quantification of antibody therapeutics (PSTR111.18), highlighting our collaborative work with Roche.
5 months ago
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Booths open today! Find us at Booth #3224 during
#SfN25
from Nov. 15-19, where we'll be sharing our latest advances in tissue clearing, light sheet imaging, and 3D quantification. We're also presenting posters throughout the conference. Stay tuned for poster presentation details!
5 months ago
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Today we will be presenting our first poster (PSTR049.03), where we will highlight tools we've developed to streamline the analysis of large, terabyte-scale light sheet datasets.
5 months ago
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If you have been following along, you will know that we are sharing multiple posters at the Society for Neuroscience (SfN) Annual Meeting in San Diego, California!
5 months ago
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We have one final
#SfN2025
poster to announce!
5 months ago
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We are excited to announce another poster that we have worked on in collaboration with Innopsys.
5 months ago
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Weāre excited to announce another poster that we will be presenting at
#SfN2025
!
5 months ago
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Thank you for joining us at our recent Lunch and Learn, hosted in collaboration with the Innovation Core at the Weill Institute for Neurosciences at the University of California, San Francisco.
5 months ago
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Happening tomorrow! Join us for a Lunch and Learn event in collaboration with the Innovation Core at the Weill Institute for Neurosciences at UC San Francisco.
5 months ago
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Time is running out! Grab a spot while you still can! Next week, join us for a Lunch and Learn event in collaboration with the Innovation Core at the Weill Institute for Neurosciences at UC San Francisco, on Wednesday, November 5th!
5 months ago
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Happening in a few weeks! Join us for a Lunch and Learn event in collaboration with the Innovation Core at the Weill Institute for Neurosciences at UC San Francisco on November 5th!
5 months ago
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Recent FDA approvals of antibody therapeutics for Alzheimer's Disease, such as Leqembi and Kinsula, mark an important advancement in CNS drug discovery. (1/5)
5 months ago
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We are excited to announce the first of our posters that we will be presenting at
#SfN25
this year! Recent advances in tissue clearing and light sheet microscopy enable unprecedented, brain-wide 3D imaging at cellular resolution.
@sfn.org
6 months ago
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Translucence Biosystems will be hosting a Lunch and Learn in collaboration with the Innovation Core at the Weill Institute for Neurosciences at the University of California, San Francisco, on November 5th!
6 months ago
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Happy
#FluorescenceFriday
! This video, generated by Jose Maldonado, shows Myelin Basic Protein (MBP) in a whole-mouse brain. MBP is a component of the myelin sheath, which insulates nerve fibers and plays an important role in nerve signal transmission. ā
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6 months ago
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We are excited to announce we'll be attending
#SfN25
in San Diego, California, from Nov. 15-19. Visit Translucence Biosystems atĀ Booth #3224Ā to learn about our latest advances in whole-brain imaging and tissue clearing.
6 months ago
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We are excited to highlight tissue clearing data generated by Dr. Ian Smith at
@ucirvine.bsky.social
. This cleared mouse brain sample, stained for amyloid (Amylo-Glo, green) and capillaries (cyan), reveals the brainās microvascular network and amyloid pathology in intact tissue.
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6 months ago
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We appreciate the kind words from one of our kit users, Dr. Ian Smith! Dr. Smith is a Research Professor at the University of California, Irvine, and used the Translucence Universal Tissue Clearing Kit to clear a mouse brain.
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7 months ago
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Happy
#FluorescenceFriday
! This video, generated by Jose Maldonado, of a mouse brain stained for Tyrosine Hydroxylase (TH) reveals dopaminergic neurons using our Universal Tissue Clearing Kit!
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7 months ago
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Weāre excited to share beautiful data from one of our kit users, UC Irvine Research Professor Dr. Ian F. Smith. Using the Translucence Universal Tissue Clearing Kit, Dr. Smith cleared a mouse brain to visualize amyloid (Amylo-Glo, green) and capillaries (cyan).
7 months ago
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Happy
#FluorescenceFriday
! iDISCO-based tissue clearing and whole-organ Light Sheet Fluorescence Microscopy (#LSFM) reveal 3D vasculature and bile duct networks in an intact mouse liver stained for Smooth Muscle Actin (cyan; vasculature) and Cytokeratin 7 (green; bile ducts).
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7 months ago
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Congratulations to the team at Denali Therapeutics on their new publication in Science showing that a transferrin receptorātargeted antibody vehicle enhances brain delivery of anti-amyloid therapy while reducing ARIA.
7 months ago
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Jenna McCloskey is a Ph.D. candidate in the Neuroscience Graduate Program at
@umich.edu
and recently used a Translucence Neuronal Activity Tissue Clearing Kit for her ratābrain work. See what she has to say about the kits below!
8 months ago
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New publication in
@nature.com
Neuroscience from our collaboration with the Olson Lab (
@ucdavis.bsky.social
) and the Heifits Lab (Stanford). The study demonstrates that TBGāa non-hallucinogenic analogue of 5-MeO-DMTācan promote cortical neuroplasticity without inducing hallucinogenic effects.
8 months ago
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Kiara Wiggins is a Ph.D. Candidate at UC Irvine and used a Translucence tissue clearing kit to clear mouse pituitary glands as part of her research on how inflammation affects women's reproductive health and polycystic ovary syndrome (PCOS).
8 months ago
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Thank you for joining us at
#AAIC25
in
#Toronto
. CEO Damian Wheeler presented two posters, "Whole Brain Measurement of Amyloid Plaques and Neuroinflammation in AD Model Mice" and "Brain-Wide Cellular-Resolution Measurement of Antibody Therapeutic Biodistribution."
8 months ago
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Heidi Fresenius is a Postdoctoral Scholar at UC Irvine. Using their established antibodies and the Translucence Universal Tissue Clearing Kit, Heidi cleared ~50 µm mouse brain sections for a pilot experiment, followed by imaging on both wide field and confocal microscopes.
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8 months ago
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We are excited to attend
#AAIC25
next week, where our CEO, Damian Wheeler, will be presenting some of the work we have been doing with our Tissue Clearing and Quantification Pipeline.
8 months ago
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We love seeing what people are able to generate using our tissue clearing kits! Pictured below is a cleared thick mouse brain slice stained for amyloid (mOC78) and astrocytes (GFAP) by Heidi Fresenius, a Postdoctoral Scholar at UC Irvine.
9 months ago
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Translucence Biosystems CEO Dr. Damian Wheeler will be attending
#AAIC25
in
#Toronto
from July 27ā31! Heāll be connecting with the
#Alzheimerās
research community and presenting two posters showcasing how tissue clearing is advancing the study of Alzheimerās disease.
9 months ago
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Translucence tissue clearing kits are ideal for next-generation 3D histology across various tissues. It stands out as the preferred option for researchers seeking an easy path to expert-level tissue clearing, so researchers can focus on what matters most ā their discoveries.
9 months ago
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Thank you for joining us at our recent Brunch and Learn, hosted in collaboration with the
@ucsdmedschool.bsky.social
Microscopy Core. We enjoyed sharing how tissue clearing is transforming biological research and discussing specific applications with attendees. (1/2)
11 months ago
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