cFos has been used for decades to map neuronal activity, however its expression is not a direct readout of neuronal activity, as cFos expression can be induced by broader signaling pathways, including cAMP-dependent pathways, neurotrophins, and other paracrine factors.

We are excited to attend the ASGCT 2026 Annual Meeting in #Boston this week, from May 11th to 15th. @asgct.bsky.social brings together the global cell and gene therapy community across scientific, translational, and regulatory areas to help advance these critical therapeutic areas.

Happy #FluorescenceFriday! This visualization shows a cleared whole-mouse spinal cord with left and right motor cortex neurons labeled in different fluorescent colors and traced continuously down the intact spinal cord in 3D.

On Monday, Translucence Biosystems attended the rally in Sacramento, CA, in support of SB 895, the California Science and Health Research Bond Act.

This 2D pan-through from a 3D light-sheet dataset shows a cleared mouse brain hemisphere stained for human IgG (red) and amyloid plaques (green).

This side-by-side 2D view of a cleared kainic acid–induced seizure mouse hemisphere shows #Npas4 immunoreactivity in green and #cFos immunoreactivity in red. At baseline, Npas4 expression is minimal, while cFos exhibits relatively high baseline levels of expression.

Happy #FluorescenceFriday! Here is another look at how tissue clearing can support the evaluation of novel human antibody therapeutics for CNS-related diseases.

This visualization shows whole-brain tyrosine hydroxylase (TH) staining in a cleared mouse brain, revealing dopaminergic neuron cell bodies and projections at cellular resolution throughout the intact brain.

The data in this video highlights the power of tissue clearing for evaluating novel human antibody therapeutics for CNS-related disorders.

Happy #FluorescenceFriday! Today we are excited to share this video which shows a cleared mouse brain hemisphere following depletion of endogenous microglia and transplantation of human cells (magenta).

We had a great time at AD/PD™ 2026 in #Copenhagen, engaging with researchers driving advances in neurodegenerative disease research!

Today, we are presenting two posters at AD/PD™ 2026. Poster #3404 examines whole-brain measurement of plaques, microglia, α-synuclein, and tyrosine hydroxylase in AD and PD model mice using tissue clearing, light sheet imaging, and AI-powered quantification.

Today marks the start of AD/PD™ 2026 in #Copenhagen! We are excited to join the community this week to discuss new approaches for measuring CNS disease pathology and therapeutic distribution across intact brain tissue.

We are excited to announce our second poster that we will be presenting at AD/PD™ 2026!

We are excited to announce our first poster that we will be presenting at AD/PD™ 2026!

For the first Fluorescence Friday of the month, we want to take a moment to recognize Brain Awareness Month and celebrate the researchers and technologies helping us better understand the brain in health and disease.

Join CEO, Damian Wheeler, and Director of Products and Business Development, Nathaniel Guanzon, at #ADPD2026 as they present recent work applying our brain-wide measurement techniques to the evaluation of CNS therapeutics and disease pathology in intact tissue.

This dataset shows α-synuclein staining (green) in a cleared mouse brain following direct PFF injection. The video reveals the distribution of α-synuclein fibrils and cell bodies at cellular resolution across the intact brain.

This dataset shows alpha-synuclein staining in a cleared mouse brain following direct PFF injection. The video reveals the distribution of alpha-synuclein fibrils and nuclei at cellular resolution across the intact brain.

Your first look at our newest tissue clearing technology, TB.Clear™!   Tissue clearing has transformed how we study intact biological systems, but many solvent-based methods (including widely used protocols like iDISCO+) can quench endogenous fluorescence.

Today was the first day of the FLAIR workshop! Are you or someone you know attending? Be sure to stop by our booth between all of the amazing talks and demos happening between today and Thursday! We are excited to discuss the ways we can support your research.

We’re excited to attend and sponsor the Fluorescence Advanced Imaging Research (FLAIR) Workshop! FLAIR brings together the legacy Laboratory for Fluorescence Dynamics (LFD) and Advanced Imaging Methods (AIM) workshops.

Happy New Year from Translucence Biosystems! We’re excited to continue helping researchers turn intact tissues into actionable insights. Wishing you a year of strong data, smooth experiments, and big breakthroughs.

Happy Holidays from Translucence Biosystems!

Happy Thanksgiving! We are thankful for all of our amazing clients, colleagues, and collaborators! Wishing everyone a safe and happy holiday. P.S It's a great time of year to try out the new Translucence Biosystems Turkey Tissue Clearing Protocol 😉

We had a great time at the Society for Neuroscience (SfN) Annual Meeting in San Diego last week! It was great connecting with friends and partners in the neuroscience community.

Day 3 of #Neuroscience2025! Join us for our final poster highlighting collaborative work with Innopsys on “High Throughput Immunohistochemistry Imaging and Quantification Using PMT-Generated Images and Cloud-Based ML-Powered Software” (PSTR198.22) from 8 AM - 12 PM.

We're presenting three posters today from 1-5 PM covering brain-wide quantification of AD pathology (PSTR111.19), tools for mapping neuronal activity with Npas4 and cFos (PSTR143.04), and brain-wide quantification of antibody therapeutics (PSTR111.18), highlighting our collaborative work with Roche.

Booths open today! Find us at Booth #3224 during #SfN25 from Nov. 15-19, where we'll be sharing our latest advances in tissue clearing, light sheet imaging, and 3D quantification. We're also presenting posters throughout the conference. Stay tuned for poster presentation details!

Today we will be presenting our first poster (PSTR049.03), where we will highlight tools we've developed to streamline the analysis of large, terabyte-scale light sheet datasets.

If you have been following along, you will know that we are sharing multiple posters at the Society for Neuroscience (SfN) Annual Meeting in San Diego, California!

We have one final #SfN2025 poster to announce!

We are excited to announce another poster that we have worked on in collaboration with Innopsys.

We’re excited to announce another poster that we will be presenting at #SfN2025!

Thank you for joining us at our recent Lunch and Learn, hosted in collaboration with the Innovation Core at the Weill Institute for Neurosciences at the University of California, San Francisco.

Happening tomorrow! Join us for a Lunch and Learn event in collaboration with the Innovation Core at the Weill Institute for Neurosciences at UC San Francisco.

Time is running out! Grab a spot while you still can! Next week, join us for a Lunch and Learn event in collaboration with the Innovation Core at the Weill Institute for Neurosciences at UC San Francisco, on Wednesday, November 5th!

Happening in a few weeks! Join us for a Lunch and Learn event in collaboration with the Innovation Core at the Weill Institute for Neurosciences at UC San Francisco on November 5th!

Recent FDA approvals of antibody therapeutics for Alzheimer's Disease, such as Leqembi and Kinsula, mark an important advancement in CNS drug discovery. (1/5)

We are excited to announce the first of our posters that we will be presenting at #SfN25 this year! Recent advances in tissue clearing and light sheet microscopy enable unprecedented, brain-wide 3D imaging at cellular resolution. @sfn.org

Translucence Biosystems will be hosting a Lunch and Learn in collaboration with the Innovation Core at the Weill Institute for Neurosciences at the University of California, San Francisco, on November 5th!

Happy #FluorescenceFriday! This video, generated by Jose Maldonado, shows Myelin Basic Protein (MBP) in a whole-mouse brain. MBP is a component of the myelin sheath, which insulates nerve fibers and plays an important role in nerve signal transmission. →

We are excited to announce we'll be attending #SfN25 in San Diego, California, from Nov. 15-19. Visit Translucence Biosystems at Booth #3224 to learn about our latest advances in whole-brain imaging and tissue clearing.

We are excited to highlight tissue clearing data generated by Dr. Ian Smith at @ucirvine.bsky.social. This cleared mouse brain sample, stained for amyloid (Amylo-Glo, green) and capillaries (cyan), reveals the brain’s microvascular network and amyloid pathology in intact tissue.

We appreciate the kind words from one of our kit users, Dr. Ian Smith! Dr. Smith is a Research Professor at the University of California, Irvine, and used the Translucence Universal Tissue Clearing Kit to clear a mouse brain.

Happy #FluorescenceFriday! This video, generated by Jose Maldonado, of a mouse brain stained for Tyrosine Hydroxylase (TH) reveals dopaminergic neurons using our Universal Tissue Clearing Kit!

We’re excited to share beautiful data from one of our kit users, UC Irvine Research Professor Dr. Ian F. Smith. Using the Translucence Universal Tissue Clearing Kit, Dr. Smith cleared a mouse brain to visualize amyloid (Amylo-Glo, green) and capillaries (cyan).

Happy #FluorescenceFriday! iDISCO-based tissue clearing and whole-organ Light Sheet Fluorescence Microscopy (#LSFM) reveal 3D vasculature and bile duct networks in an intact mouse liver stained for Smooth Muscle Actin (cyan; vasculature) and Cytokeratin 7 (green; bile ducts).

Congratulations to the team at Denali Therapeutics on their new publication in Science showing that a transferrin receptor–targeted antibody vehicle enhances brain delivery of anti-amyloid therapy while reducing ARIA.

Jenna McCloskey is a Ph.D. candidate in the Neuroscience Graduate Program at @umich.edu and recently used a Translucence Neuronal Activity Tissue Clearing Kit for her rat‑brain work. See what she has to say about the kits below!