Exploring the role of short peptide motifs (focusing on Walker A P-loop) at the origins of life using simulations. Discussion of collaborative work with the @liamlongo.bsky.social and other colleagues. What can molecular fossils teach us about the first proteins? theconversation.com/molecular-fo...

Representation shapes the questions we ask. Here, we use contrastive learning to unite sequence and structure and build a new, global "map" of protein space. Preprint: www.biorxiv.org/content/10.1... Congratulations to Guy Yanai, who led this work, Rachel Kolodny, Nir Ben Tal, and Gabriel Axel

Is phylogenetics the only record of protein history? No! Led by Tatsuya Corlett, we show that the history of enzymes is written into the structure of metabolism. From there, we reconstruct a self-consistent model of metabolic and enzyme evolution. www.biorxiv.org/content/10.1...

"Protein Problem: Georgia Tech Researchers Challenge Fundamental Assumption in Evolutionary Biochemistry", GT press release on our latest paper with @liamlongo.bsky.social and colleagues. research.gatech.edu/protein-prob...

Excited to announce that @preinerin.bsky.social, @colemathis.bsky.social and I were awarded an @hfspo.bsky.social research grant! 🎉 If you are an experimentalist interested in studying protein histories as a graduate student in the Longo Lab ELSI, please get in touch.

Our ambidextrous HhH peptide is now in @angewandtechemie.bsky.social Proud of the great team @liamlongo.bsky.social , Metanis lab and Koby Levy lab

Redefining the Limits of Functional Continuity in the Early Evolution of P-Loop NTPases Now out in Molecular Biology and Evolution Exciting collaboration with @lynnkamerlin.bsky.social academic.oup.com/mbe/advance-...

Functional Ambidexterity of an Ancient Nucleic Acid-Binding Domain Now out now in @angewandtechemie.bsky.social Exciting collaboration with Norman Metanis and Koby Levy onlinelibrary.wiley.com/doi/10.1002/...

Need phosphorylating power? Maybe our universal polyphosphate kinase can help! ATP ✅ GTP ✅ CTP ✅ UTP ✅ in vitro transcription ✅ An energizing collaboration with the Matsuura Group @ ELSI. Check out the preprint here👇 www.biorxiv.org/content/10.1...