Zane Lybrand
@zane-of-science.bsky.social
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Assistant prof @TWU Building neural systems to understand brain trauma LybrandLab.org
www.nature.com/articles/s41...
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Spatial transcriptomics reveals human cortical layer and area specification - Nature
Multiplexed error-robust fluorescence in situ hybridization (MERFISH) together with deep-learning-based nucleus segmentation enabled the construction of a highly detailed and informative spatially res...
https://www.nature.com/articles/s41586-025-09010-1
7 months ago
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Myles gave his Biology Seminar talk on stem cell derived cortical graft for brain repair.
8 months ago
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I will stop whatever I'm doing anytime a student excitedly knocks on my door to show me new data.
8 months ago
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reposted by
Zane Lybrand
TK (Takashi DY) Kozai
10 months ago
NIH Funds remain frozen using a loophole to try to circumvent judge's orders. Call your elected representatives including Governor and state AG (or DC AG). Express your concern that this will hurt the economy, livelihood, &long-term health of constituents
www.nature.com/articles/d41...
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Revealed: NIH research grants still frozen despite lawsuits challenging Trump order
The Trump administration is exploiting a loophole to keep a funding freeze in place, leaving researchers in limbo.
https://www.nature.com/articles/d41586-025-00540-2
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Zane Lybrand
Katie Wilkinson
10 months ago
Helpful table to determine how much your University or health system is set to lose if the NIH indirect cap is suddenly lowered to 15%. For SJSU it is $374k which is on the smaller end but devastating considering our other budget issues.
datawrapper.dwcdn.net/l0ZqA/8/
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Estimated Single Year Loss of NIH Funding if 15% Indirect Cost Rate is Imposed
Based on analysis of 2024 NIH funding data. Sums are totals of losses in funding to programs if indirect costs had been capped at 15%
https://datawrapper.dwcdn.net/l0ZqA/8/
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The economic impact on North Texas due to the 15% F&A cap is thousands of jobs lost, over $500M in annual economic activity gone, and delays to life-saving research on diseases like cancer and Alzheimer’s. Read my letter to Congress and report here:
10 months ago
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Zane Lybrand
Carl T. Bergstrom
10 months ago
1. Today the NIH director issued a new directive slashing overhead rates to 15%. I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
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NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
https://grants.nih.gov/grants/guide/notice-files/NOT-OD-25-068.html
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Fascinated by how the brain networks balance flexibility and stability. Stochastic ensembles in the dlPFC show that transient, dynamic neuron networks can produce reliable population-level representations. A key to understanding cognitive flexibility and resilience!
www.cell.com/current-biol...
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Recurrent activity propagates through labile ensembles in macaque dorsolateral prefrontal microcircuits
Using ex vivo Ca2+ imaging in macaque dorsolateral prefrontal cortex, Nolan et al. reveal that recurrent activity propagates through unstable, stochastically assembled ensembles to produce stable population-level events. Network excitability covaried with set-shifting performance, suggesting that these features may underlie dlPFC’s role in cognition.
https://www.cell.com/current-biology/fulltext/S0960-9822(24)01636-1
11 months ago
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Opening work email after an extended (and amazing) break can feel overwhelming. My strategy: flag and categorize each email by importance and urgency, then delete the unimportant/non-urgent ones. Today, I cleared about 80%. The Eisenhower Matrix is a game changer:
www.forbes.com/sites/hillen...
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How To Get Stuff Done: The Eisenhower Matrix (a.k.a. The Urgent Vs The Important)
I have found that one of the best frameworks for helping get things done is the classic “urgent vs. important” two-by-two matrix.
https://www.forbes.com/sites/hillennevins/2023/01/05/how-to-get-stuff-done-the-eisenhower-matrix-aka-the-urgent-vs-the-important/
11 months ago
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Got to catch up with
@gopu.bsky.social
12 months ago
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reposted by
Zane Lybrand
Kayson Fakhar
12 months ago
And the same for Python is here:
python-graph-gallery.com/color-palett...
add a skeleton here at some point
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Lots of great reviews out now on networks. Metastability is a new concept for me but digging it. Something we've observed in the lab but haven't linked to attractor dynamics or used that terminology.
www.nature.com/articles/s41...
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Metastability demystified — the foundational past, the pragmatic present and the promising future - Nature Reviews Neuroscience
Metastability is a concept from dynamical systems. In the brain, it is thought to reflect the balance between the cooperative and independent functioning of brain areas or neuronal populations. In thi...
https://www.nature.com/articles/s41583-024-00883-1#Glos20
about 1 year ago
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A nice review of neural oscillations across multiple timescales enable multisensory integration by aligning, segregating, and prioritizing sensory inputs. Fig. 1 is nice. I may print and hang in my office.
www.nature.com/articles/s41...
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Multi-timescale neural dynamics for multisensory integration - Nature Reviews Neuroscience
How the brain routinely processes information from different sensory modalities during everyday tasks is not well understood. In this Perspective, Engel and Senkowski propose how oscillatory neural me...
https://www.nature.com/articles/s41583-024-00845-7#Glos7
about 1 year ago
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I change my email sign-off from 'Regards' to 'Sincerely' just so you know I'm serious.
about 1 year ago
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What a fascinating study on how amygdala networks shift to repetitive 'stay or switch' patterns during stress, disrupting focus on rewards! Stress rewires decision-making circuits, shedding light on how neural dynamics drive overthinking.
www.nature.com/articles/s41...
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Understanding the neural code of stress to control anhedonia - Nature
Examination of the neural activity in the basolateral amygdala and ventral CA1 of mice during tasks or rest following exposure to social stress reveals signatures of resilience and susceptibility to s...
https://www.nature.com/articles/s41586-024-08241-y
about 1 year ago
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Neurons in the human brain multitask! Shared neurons fire in bursts for multiple stimuli, but their firing order shifts to create stimulus-specific sequences. A clever, dynamic way the brain encodes complex info.
www.nature.com/articles/s41...
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Neuronal sequences in population bursts encode information in human cortex - Nature
The temporal order of neuronal firing within bursts of population spiking in the human anterior temporal lobe is dependent on the category as well as the identity of the individual stimulus, and this ...
https://www.nature.com/articles/s41586-024-08075-8
about 1 year ago
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reposted by
Zane Lybrand
SfN Journals
about 1 year ago
#JNeurosci
: Papale et al. mapped out connections between neurons in mice that form the cellular basis of coordinated movement planning across the two hemispheres of the frontal cortex.
doi.org/10.1523/JNEU...
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I'm going to need a starter pack of starter packs at this point.
about 1 year ago
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I've been on Bluesky for a few months and I am really thrilled to see it taking off. Rediscovering old twitter networks over the past few days has been fun.
about 1 year ago
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First time I wasn't able to make it to one of my favorite meetings but the lab still represented.
#MissionConnect
about 1 year ago
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Yet another report by NYT on CTE from the military. It's pervasive. We need to help them. “Over and over and over, high-performing guys spiral down and fall apart,”
www.nytimes.com/2024/11/12/u...
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Chronic Brain Trauma Is Extensive in Navy’s Elite Speedboat Crews
The pounding that sailors’ brains take from years of high-speed wave-slamming in the Special Boat Teams can cause symptoms that wreck their careers — and their lives.
https://www.nytimes.com/2024/11/12/us/brain-trauma-cte-navy-speedboat.html?smid=nytcore-ios-share&referringSource=articleShare
about 1 year ago
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about 1 year ago
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I'm feeling a little guilty enjoying these proper fall temps away from the heat wave we have at home.
#sfn2024
about 1 year ago
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reposted by
Zane Lybrand
Earl K. Miller
about 1 year ago
One week from tonight. The premiere event of the Society for Neuroscience meeting.
#SfN24
#SFN2024
www.reggieslive.com/show/pavlovs...
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reposted by
Zane Lybrand
bioRxiv Neuroscience
about 1 year ago
Neurophysiological signatures of default mode network dysfunction and cognitive decline in Alzheimer disease. https://www.biorxiv.org/content/10.1101/2024.09.16.613373v1
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Neurophysiological signatures of default mode network dysfunction and cognitive decline in Alzheimer disease. https://www.biorxiv.org/content/10.1101/2024.09.16.613373v1
Neural hyper-excitability and network dysfunction are neurophysiological hallmarks of Alzheimer dise
https://www.biorxiv.org/content/10.1101/2024.09.16.613373v1
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reposted by
Zane Lybrand
bioRxiv Neuroscience
over 1 year ago
The dual interpretation of edge time series: Time-varying connectivity versus statistical interaction https://www.biorxiv.org/content/10.1101/2024.08.29.609259v1
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The dual interpretation of edge time series: Time-varying connectivity versus statistical interaction https://www.biorxiv.org/content/10.1101/2024.08.29.609259v1
Functional connectivity (FC) is frequently operationalized as a correlation. Many studies have exami
https://www.biorxiv.org/content/10.1101/2024.08.29.609259v1
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Who's got 2 thumbs and didn't think it would be a disaster to make an assignment due on the first day of class? This guy.
over 1 year ago
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www.nature.com/articles/s41...
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Abstract representations emerge in human hippocampal neurons during inference - Nature
A task in which participants learned to perform inference led to the formation of hippocampal representations whose geometric properties reflected the latent structure of the task, indicating tha...
https://www.nature.com/articles/s41586-024-07799-x
over 1 year ago
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PRIME Academy Intern poster presentations.
over 1 year ago
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FA24 is quickly approaching and so are the all day faculty workshops and events.
over 1 year ago
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elifesciences.org/reviewed-pre...
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Indistinguishable network dynamics can emerge from unalike plasticity rules
https://elifesciences.org/reviewed-preprints/94411
over 1 year ago
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Mustering more energy to check out yet another platform.
over 1 year ago
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