Modelling dynamic host-pathway interactions at the genome scale with machine learning doi.org/10.1016/j.ym...

When talk to colleagues, I see a growing interest in the central question of this paper: what if we’ve been designing genetic circuits the wrong way? After all, natural networks *look* very different. This work, which has gone somewhat unnoticed, is one of my favourites! doi.org/10.1162/isal...

Pseudomonas putida joins the Olympus of effective Cell Factories www.nature.com/articles/s41... Not any longer *a promising platform* for metabolic engineering, but a phenomenal, consolidated chassis for programming degradation and synthesis of amazing molecules 😃!

Great start of the year meal with the lab!

Are you looking looking to engineer chemical production in batch cultures? In our recent paper with Ahmad Mannan we show show to design genetic circuits to enhance productivity! Link: www.nature.com/articles/s41...

Really happy to contribute to this fantastic work led by Harman Mehta in collaboration with Rodrigo Ledesma and @gbstan.bsky.social!! Harman demonstrates that a microbial biosynthetic pathway can be more efficient if divided between two strains 👏🎉🎊 www.biorxiv.org/content/10.1...

Are you heading to Synthetic Biology UK? #BiochemEvent #SBUK2024 Unfortunately I am teaching but you can check out three posters from the group! Go and say hi!

4 PhD positions available in my lab. All membranes / biotech focussed with interdisciplinary friends and industry. www.linkedin.com/posts/alan-g...

What happens if you delete the resource-expensive flagella? Published today doi.org/10.1111/1751-7…, Juhyun Kim’s group shows such deletions can create a flexible P putida cell factory!

Risk-averse optimization of genetic circuits under uncertainty doi.org/10.1101/2024...