Antonio J. Pérez Pulido 🧬🦠💻🦼 (@ajperezpulido.bsky.social)

We present the full story of the PPTOP vs DgiS1 phage battle using Acinetobacter baumannii bacteria as the battleground. PPTOP is a phage-plasmid that, among other weapons, carries a CRISPR-Cas I-Fa system specialized in targeting DgiS1. www.cell.com/cell-reports...

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Biological warfare between two bacterial viruses in a defense archipelago sheds light on the spread of CRISPR-Cas systems Rubio et al. describe an archipelago of anti-phage systems in the opportunistic pathogenic bacterium A. baumannii. This is the battleground of two phages fighting for integration. One of them inserts a CRISPR-Cas system that prevents the other from integrating, and the other could escape by mutations avoiding the CRISPR-Cas system. https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01436-0