Julia Vorhauser
@juliavorhauser.bsky.social
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Postdoc in the Wredenberg lab at Karolinska Institute. Interested in redox biology and metabolism :D
reposted by
Julia Vorhauser
H.P.
15 days ago
„Man kann sich mit dem Nationalsozialismus geistig nicht auseinander-setzen, weil er ungeistig ist." Alexander Schmorell, Mitbegründer der Widerstandsgruppe Weiße Rose, Verfasser bekannter Flugblätter der Gruppe, wurde am 16 September 1917 geboren. Guten Morgen 
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reposted by
Julia Vorhauser
The Institute of Cancer Research
about 1 month ago
The findings highlight a new way of thinking about how cell growth is controlled – one that could eventually be harnessed to improve cancer treatment ⤵️
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Subtle chemical tweak helps determine whether cells grow, potentially affecting cancer risk
Subtle chemical tweak helps determine whether cells grow, potentially affecting cancer risk
https://www.icr.ac.uk/about-us/icr-news/detail/subtle-chemical-tweak-helps-determine-whether-cells-grow--potentially-affecting-cancer-risk
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I am very happy to share that my PhD work in the Mansfeld lab (
www.mansfeldlab.com
) was published yesterday! 🎉 In this study, we characterized a novel redox switch on p21 that regulates proliferation:
www.cell.com/molecular-ce...
Huge thanks to everyone involved for making this possible 🙏@icr.ac.uk
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A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision
ROS oxidize cell cycle proteins and regulate cell proliferation. Vorhauser et al. show that oxidation of the cyclin-dependent kinase (CDK) inhibitor p21 at cysteine 41 (C41) during the G2 phase contro...
https://www.cell.com/molecular-cell/fulltext/S1097-2765(25)00646-X
about 1 month ago
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reposted by
Julia Vorhauser
MRC Laboratory of Medical Sciences
9 months ago
New research from Steve Cutty and
@alexisbarr.bsky.social
published in the British Journal of Cancer shows the protein p21 promotes survival in lung cancer cells strengthening the rationale for targeting p21 as a cancer treatment. This work was also funded by
@cancerresearchuk.org
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Blocking the cell cycle inhibitor p21 prevents regrowth in lung cancer cells
Blocking the activity of a protein called p21 stops lung cancer cells entering a ‘sleep-like’ state that allows them to survive chemotherapy. Blocking p21 causes more cancer cells to die and reduces t...
https://lms.mrc.ac.uk/blocking-the-cell-cycle-inhibitor-p21-prevents-regrowth-in-lung-cancer-cells/
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