@davehulcoop.bsky.social
π€ 117
π₯ 637
π 1
reposted by
Open Targets
8 months ago
The Open Targets Platform autumn release is out! π We have ingested the full dataset of over 13 million enhancer-gene regulatory interactions in the human genome across 1,458 DNase-seq experiments covering 369 cell types and tissues from the ENCODE-rE2G model
blog.opentargets.org/open-targets...
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Open Targets Platform 25.09 has been released!
The September 25 release includes enhancer-gene data predicted by ENCODE-rE2G, molQTL credible sets for targets, new options for the variant structural viewer, and a number of data updates from GWAS C...
https://blog.opentargets.org/open-targets-platform-25-09-release/
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reposted by
Mallory Freeberg
10 months ago
𧬠New
@emblebi.bsky.social
service beta launched: Perturbation Catalogue π Browse genetic perturbation datasets π§ Train models 𧬠Interpret variant function π§ Explore gene dependencies Search, test APIs, suggest datasets, send feedback! π
www.ebi.ac.uk/perturbation...
Funded by
@opentargets.org
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reposted by
Open Targets
12 months ago
Open Targets Platform 25.06 is out now! π» It includes 36% more GWAS credible sets (including from the VA Million Veteran Program study) and a new target interactors view to help nominate potential targets
blog.opentargets.org/open-targets...
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Open Targets Platform 25.06 has been released!
This release brings in 36% more GWAS credible sets, association evidence for a target's interactors, revamped data downloads page and molecular structure viewers, gene burden data from the Broad CVDI ...
https://blog.opentargets.org/open-targets-platform-25-06-release/
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Very excited to share the latest work of the team
@opentargets.org
. If you are interested in
#targetdiscovery
and
#genetics
check out the latest release of the Open Targets Platform.
add a skeleton here at some point
about 1 year ago
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reposted by
Open Targets
over 1 year ago
What can we learn from 95 projects across 10 years of industry-academic collaboration? π€ In a comment for Nature Reviews Drug Discovery, the Open Targets Directors shared their insights on what makes a successful and impactful project π§ͺπ§¬
www.nature.com/articles/d41...
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Open Targets: 10 years of partnership in target discovery
The Open Targets consortium was founded in 2014 to translate insights from genetics and functional genomics into identifying and prioritizing therapeutic targets. We highlight key achievements and ins...
https://www.nature.com/articles/d41573-024-00204-2
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reposted by
Open Targets
over 1 year ago
We're hiring! π©βπ¬π§¬π» β‘ Staff Scientist: high-throughput sc CRIPSR screening in neurodegenerative disease β‘ Data Manager (part time), the point of contact for Open Targets project data β‘ Postdoc: Neurodegenerative Disease Immune Response Modelling
opentargets.org/jobs
#neurojobs
#sciencejobs
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Jobs - Open Targets
Open Targets is a public-private initiative to generate evidence on the validity of therapeutic targets based on genome-scale experiments and analysis.
https://opentargets.org/jobs
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reposted by
Open Targets
over 1 year ago
With the gget opentargets module, you can now interact directly with the Open Targets database from a Python or command line environment Developed by
@lauraluebbert.com
, gget is a free, open-source tool enabling efficient querying of large genomic databases π₯οΈπ§¬
blog.opentargets.org/case-study-g...
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Case study: ggetβs new Open Target module
The new gget opentargets module allows users to communicate directly with the Open Targets database from a Python or command line environment. Amongst other tasks, gget opentargets can quickly find di...
https://blog.opentargets.org/case-study-gget/
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reposted by
Open Targets
over 1 year ago
ποΈNew preprint! Maria Falaguera developed a method to comprehensively track the accumulation of literature-derived, genetic and clinical evidence linking targets to disease over time, and to identify novel drug target opportunities π§¬π₯οΈ
www.researchsquare.com/article/rs-5...
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Temporal trends in novel drug target discovery reveal the increasing importance of human genetic data
Drug approvals involving novel mechanism-of-action targets currently account for about one-fifth of new FDA-approved drugs each year. Developing therapies for novel targets carries added risks, but th...
https://www.researchsquare.com/article/rs-5669559/v1
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