Freya Allen
@freyaallen.bsky.social
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PhD student at the University of Birmingham | AMR, evolution and enterococci
reposted by
Freya Allen
Dr Ross McInnes
9 days ago
Amazing work from
@freyaallen.bsky.social
and
@prob91.bsky.social
. I truly believe that Rob is the Sherlock Holmes of MGEs and one of the leaders in the field of artisanal bioinformatics๐!
add a skeleton here at some point
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reposted by
Freya Allen
Rob Moran
9 days ago
Our new paper in MGen traces the evolution of a plasmid lineage associated with MDR in Enterococcus faecium, primarily driven by IS1216 For anyone interested in plasmid structures and the smaller MGEs that shape them ๐งต๐ [1/14]
@microbiologysociety.org
www.microbiologyresearch.org/content/jour...
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IS1216 drives the evolution of pRUM-like multidrug resistance plasmids in Enterococcus faecium
pRUM-like plasmids are commonly found in multidrug-resistant Enterococcus faecium, but the evolution of these plasmids has not been characterised in detail. When we analysed the genome sequences of tw...
https://www.microbiologyresearch.org/content/journal/mgen/10.1099/mgen.0.001598
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reposted by
Freya Allen
Willem van Schaik
about 2 months ago
Delighted that our review on resistance to last-resort antibiotics in Enterococci has been published in FEMS Microbiology Reviews
academic.oup.com/femsre/advan...
(accepted manuscript version) TL;DR: the Enterococci are really good at evolving resistance to antibiotics in new and creative ways.
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Resistance to last-resort antibiotics in enterococci
Abstract. The genus Enterococcus comprises a diverse group of species, many of which are commensal members of the gut microbiota of humans and animals. The
https://academic.oup.com/femsre/advance-article/doi/10.1093/femsre/fuaf057/8317236?utm_source=advanceaccess&utm_campaign=femsre&utm_medium=email
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reposted by
Freya Allen
Willem van Schaik
about 2 months ago
Absolutely delighted (and proud) that
@freyaallen.bsky.social
passed her viva with minor corrections today. Thanks very much
@jessicamablair.bsky.social
@robfagan.bsky.social
for examining!
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reposted by
Freya Allen
Lilly Cummins
5 months ago
๐จNew pre-print ๐จ We introduce our new tool GOLD-GWAS and demonstrate its use by digging into the evolution of MRSA facilitated by SCCmec This work was led by talented PhD student
@seungwonko.bsky.social
who did most of the computational heavylifting 1/n
www.biorxiv.org/content/10.1...
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Genome co-adaptation and the evolution of methicillin resistant Staphylococcus aureus (MRSA)
Background: Antimicrobial resistance (AMR) in bacterial pathogens is a major threat to global health, rendering standard treatments ineffective and increasing the risk of severe infection or death. Re...
https://www.biorxiv.org/content/10.1101/2025.07.21.665857v2
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reposted by
Freya Allen
Cassie Bakshani
5 months ago
๐จ New preprint klaxon ๐จ We characterised the structure of a PNGaseA superfamily member from Bifidobacterium bifidum LMG13195 and highlight its preference for N-glycan structures attached to a peptide, rather than to a native or denatured protein ๐ซ
@imibirmingham.bsky.social
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PNGaseA-mediated N-glycan stripping from peptides by infant-derived Bifidobacterium bifidum
N-glycans are highly common sources of nutrition for human colonic-dwelling bacteria. These microbes have evolved a several methods to remove N-glycans from proteins; herein we describe the biochemica...
https://www.biorxiv.org/content/10.1101/2025.07.17.665090v1
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reposted by
Freya Allen
Willem van Schaik
5 months ago
New manuscript from the group 'IS1216 drives the evolution of pRUM-like multidrug resistance plasmids in Enterococcus faecium'
www.biorxiv.org/content/10.1...
/1
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IS1216 drives the evolution of pRUM-like multidrug resistance plasmids in Enterococcus faecium
pRUM-like plasmids are commonly found in multidrug-resistant Enterococcus faecium , but the evolution of these plasmids has not been characterised in detail. When we analysed the genome sequences of t...
https://www.biorxiv.org/content/10.1101/2025.07.10.664085v1
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