New in Nucleic Acids Research! MBD2 forms liquid condensates that organize heterochromatin and control histone acetylation. Combined proteomics + AI predictions reveal how phase separation regulates chromatin states. MBD2 recruits HDACs, excluding HATs. doi.org/10.1093/nar/...

MeCP2driven chromatin organization controls nuclear stiffness during neuronal differentiation. UsingAFM, we show heterochromatin clustering increases nuclear mechanics, disrupted by Rett mutations-severity correlates with stiffness defects, not gene expression. www.nature.com/articles/s42...

A new way to watch chromatin moving in living stem cells as they become neurons and what we saw was striking. Chromatin literally slows down as cells commit to their fate. It's like watching cells physically lock in their identity by constraining their chromatin. cardoso-lab.org/pages/public...

Our new work in EMBO Reports! 🧬 H3K36me3 enriches at pericentromeric heterochromatin BEFORE replication, regulating its timing. H3K36me3 loss disrupts satellite transcription and delays replication. Forward-strand MajSat RNA controls replication timing—ncRNAs as key regulators! cardoso-lab.org

Congratulations to Dr. Maruthi Kumar Pabba on successfully defending his PhD! What an incredible achievement! Wishing you all the best as you embark on this new chapter!! 👏🎉 #PhDLife #Congratulations @tuda.bsky.social

🧬⚡Your sunscreen is only half the story We show that near-infrared light makes UV damage WORSE. nIR loosens DNA packaging, creating a repair traffic jam that increases breaks. We are ignoring the invisible majority of solar radiation that hacks DNA repair. doi.org/10.1038/s415... @tuda.bsky.social

Our new paper is out: we explored the role KAP1 and HP1alpha in retroviral elements silencing. Check it out: doi.org/10.1038/s414... cardoso-lab.org/pages/public... @tuda.bsky.social @synbio.bsky.social

Sustainability prize of the "Freunde der TU Darmstadt" Really proud of it. Let's save the planet. 🌍 @synbio.bsky.social @tuda.bsky.social

Great opportunity for everyone to attend at DGZ focus workshop "Functional organization of the nucleus". Here is the info Zoom-ID: 961 7810 6979 Passcode: DGZ_FW

DGZ Deutsche Gesellschaft für Zellbiologie photo awards. We received a best photo award. Congratulations to our PhD student (Maruthi Kumar). Check it out www.zellbiologie.de/awards/

Warmest congratulations to Dr. Sunil K. Pradhan (@sunil-k-pradhan.bsky.social) on successfully defending his PhD thesis on genome replication and epigenetic regulation in mammalian cells! Wishing you continued success as you embark on your next chapter. 🎓"

I'm excited to share that our lab just earned the LEAF silver certificate for sustainability. Big thanks to our incredible team for making this happen. Next stop: gold!

We as well decided to join the bright side! Follow our newest research findings on Blue Sky, coming soon 😉