#LegacyContent: Beyond Redox Regulation: Novel Roles of TXNIP in the Pathogenesis and Therapeutic Targeting of Kidney Disease. Full text: ajp.amjpathol.org/article/S000...

Deficiency of Mesencephalic Astrocyte–Derived Neurotrophic Factor Aggravates Acute Pancreatitis in Mice Full text: https://ajp.amjpathol.org/article/S0002-9440(26)00003-9/fulltext

Colitogenic Environment Suppresses Notch/Mechanistic Target of Rapamycin–Mediated Epithelial Proliferation to Promote Goblet Cell Differentiation in the Colon Full text: https://ajp.amjpathol.org/article/S0002-9440(26)00005-2/fulltext

Rora Regulates Hematopoietic Stem Cell Phenotypes and Progression of Chronic Myelogenous Leukemia Full text: https://ajp.amjpathol.org/article/S0002-9440(26)00004-0/fulltext

#LegacyContent: Tissue Inhibitor of Metalloproteinase-2 Promotes Wound Healing by Suppressing Matrix Metalloproteinases and Inflammatory Cytokines in Corneal Epithelial Cells. Authors from @harvardmed.bsky.social Free in the #OpenArchive: ajp.amjpathol.org/article/S000...

Check out this new study from Mass General Brigham researchers in @ajpathology.bsky.social!

ADH1C Down-Regulation Is a Key Hypoxia Response in Colon Epithelium #OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(26)00002-7/fulltext

Keratocyte Depletion by Genetic Manipulation Re-creates Corneal Ectasia in a Mouse Model Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00465-1/fulltext

#ArticleinPress: Dermal Microvascular Responses of Human Induced Pluripotent Stem Cell–Derived Skin Organoids to Inflammation and Injury #OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(26)00030-1/fulltext

Peroxisome Proliferator-Activated Receptor α Deficiency Induces Vascular Pathologies through Endothelial Senescence in Diabetic Retinopathy #OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00466-3/fulltext

Neonatal Thymic Dynamics Influence Autoimmune Pathology by Shaping the Suppressive Potential of Regulatory T Cells #OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00467-5/fulltext

#ArticleinPress: Pseudogene-Derived Long Noncoding RNAs GSTM3P1/Gstm2-ps1 Exacerbate Sepsis-Associated Acute Kidney Injury by Suppressing Their Parent Gene Translation #OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(26)00029-5/fulltext

#LegacyContent: Characterization and Role of Glucagon-Like Peptide 1 Receptor in the Lacrimal Gland: Novel Insights into Diabetic Dry Eye Pathogenesis. Free in the #OpenArchive: ajp.amjpathol.org/article/S000...

#ArticleinPress: Leukocytic Dopamine D2 Receptors as Biomarkers for Brain Dopamine Levels in Parkinson Disease. From @asipath.bsky.social member Scott Steffensen. Full text: https://ajp.amjpathol.org/article/S0002-9440(26)00028-3/fulltext

#ArticleinPress: Redefining Pathobiology with Spatial Multi-Omics at the Intersection of Biology, Computation, and Histopathological Assessment Full text: https://ajp.amjpathol.org/article/S0002-9440(26)00032-5/fulltext

The April issue of @ajpathology.bsky.social is now live! Full issue: https://ajp.amjpathol.org/issue/S0002-9440(25)X0006-7 On the cover: Deterioration of colonic crypts in dextran sulfate sodium treated mice.

#ArticleinPress: Applications of Spatial Transcriptomics in Ischemic Stroke Research. Authors from @czechacademy.bsky.social Full text: https://ajp.amjpathol.org/article/S0002-9440(26)00033-7/fulltext

#ArticleinPress: Retinal Hypoxia as an Early-Detection Imaging Biomarker for Diabetic Retinopathy. Full text: https://ajp.amjpathol.org/article/S0002-9440(26)00009-X/fulltext

Machine Learning–Based Pathomics Model Predicts ANGPT2 Expression and Prognosis in Hepatocellular Carcinoma #OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(24)00478-4/fulltext

#LegacyContent: P46Shc Inhibits Mitochondrial ACAA2 Thiolase, Exacerbating Mitochondrial Injury and Inflammation in Aging Livers. From @asipath.bsky.social member author Natalie Török and colleagues @ucdavishealth.bsky.social. Free in the #OpenArchive: ajp.amjpathol.org/article/S000...

#LegacyContent: Genetic Loss of HIF-Prolyl-Hydroxylase 1, but Not Pharmacological Inhibition, Mitigates Hepatic Fibrosis. Free in the #OpenArchive: ajp.amjpathol.org/article/S000...

Emerging Mechanistic Roles of STING Signaling in Kidney Diseases #OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00442-0/fulltext

Throughout 2025 we published a series of #AJPCentennial editorials showcasing seminal articles that appeared in AJP over the last century, as well as some forward-looking pieces predicting the future of key areas in pathobiology. A digital compendium is online here: https://loom.ly/BKOyYJU#AJPCentennial

Mechanistic Insights into Glucocorticoid-Induced Ocular Hypertension Using Differences in Mouse Strain Responsiveness. #OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00440-7/fulltext

Systemic Disease Progression and Neurodegeneration in the Gbe1ys/ys Mouse Model of Glycogen Storage Disease Type IV. Authors from @dukehealth.bsky.social. Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00437-7/fulltext

#ArticleinPress: Organotypic Retinal Explant Culture as a Model for Neuroretinal Degenerative Disease and Future Applications. Full text: https://ajp.amjpathol.org/article/S0002-9440(26)00010-6/fulltext

#ArticleinPress: Single-Cell Triomics Analysis of Tumor Cells Infiltrating Patient-Derived Breast Cancer Scaffolds. Authors from @missionbio.bsky.social #OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(26)00008-8/fulltext

DNA Methyltransferase 3A–Dependent Suppression of Hypoxia-Inducible Factor-1α Alleviates Myopia by Reducing Scleral Ferroptosis and Fibroblast Extracellular Matrix Remodeling Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00441-9/fulltext

Be sure you're following AJP on all your preferred social channels so you never miss an update!

#ArticleinPress: Deciphering the Cellular and Metabolic Landscape of Lymph Node Metastasis in Breast Cancer Using Single-Cell and Spatial Multi-Omics Full text: https://ajp.amjpathol.org/article/S0002-9440(26)00007-6/fulltext

#ArticleinPress: Deficiency of Mesencephalic Astrocyte–Derived Neurotrophic Factor Aggravates Acute Pancreatitis in Mice Full text: https://ajp.amjpathol.org/article/S0002-9440(26)00003-9/fulltext

Our recent work shows that deficiency of ANGPTL4 causes death in one-third of newborn mice due to intestinal lymphatic malformations and inflammation, while surviving mice are more resistant to intestinal inflammation and tumor formation. @uoftpress.bsky.social @sickkidsto.bsky.social

#LegacyContent: Gut Microbiome and Bile Acid Interactions: Mechanistic Implications for #Cholangiocarcinoma Development, Immune Resistance, and Therapy. Free in the #OpenArchive: ajp.amjpathol.org/article/S000...

Delayed Bone Fracture Healing in Hybid (Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization)–Deficient Mice. #OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00438-9/fulltext

#ArticleinPress: Colitogenic Environment Suppresses Notch/Mechanistic Target of Rapamycin–Mediated Epithelial Proliferation to Promote Goblet Cell Differentiation in the Colon Full text: https://ajp.amjpathol.org/article/S0002-9440(26)00005-2/fulltext

#ArticleinPress: Rora Regulates Hematopoietic Stem Cell Phenotypes and Progression of Chronic Myelogenous Leukemia Full text: https://ajp.amjpathol.org/article/S0002-9440(26)00004-0/fulltext

#ArticleinPress: ADH1C Down-Regulation Is a Key Hypoxia Response in Colon Epithelium #OpenAccess text: https://loom.ly/Td1Wvyk

Loss of Angptl4 Protects Mice from Intestinal Colitis and Tumorigenesis with Alternative Activation of Macrophages. @utoronto.ca #OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00434-1/fulltext

#ArticleinPress: Keratocyte Depletion by Genetic Manipulation Re-creates Corneal Ectasia in a Mouse Model Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00465-1/fulltext

#Cholangiocarcinoma Theme Review Development of CAR-T Therapies and Personalized Vaccines for the Treatment of Cholangiocarcinoma: Current Progress, Mechanisms of Action, and Challenges Full text: https://ajp.amjpathol.org/article/S0002-9440(24)00442-5/fulltext

Interpreting Deep Learning–Based Prediction of the BRAF V600E Mutation Using Diagnostic Whole Slide Images in Skin Cutaneous Melanoma. @dartmouthhealth.bsky.social #OpenAccess text: https://loom.ly/xmEbb8Q

Targeting Skeletal Muscle in #DuchenneMuscularDystrophy: Integrating in Silico and Experimental Approaches to Sodium-Glucose Cotransporter-2 Inhibition. @ualberta.bsky.social #OpenAccess text: https://loom.ly/M2rbNQk

The March issue of @ajpathology.bsky.social is now live! Full issue: https://ajp.amjpathol.org/issue/S0002-9440(25)X0005-5 On the cover: Immunostaining of the small intestine of a Angptl4KO lethal mouse

YAP and TEAD Are Transcriptional Regulators of Neuroendocrine Differentiation and Growth in Carcinoid Cells #OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00411-0/fulltext

#LegacyContent: Improving Colorectal Cancer Screening and Risk Assessment through Predictive Modeling on Medical Images and Records. #OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00380-3/fulltext

Improving Colorectal Cancer Screening and Risk Assessment through Predictive Modeling on Medical Images and Records. #OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00380-3/fulltext

#ArticleinPress: Peroxisome Proliferator-Activated Receptor α Deficiency Induces Vascular Pathologies through Endothelial Senescence in Diabetic Retinopathy #OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00466-3/fulltext

#ArticleinPress: Neonatal Thymic Dynamics Influence Autoimmune Pathology by Shaping the Suppressive Potential of Regulatory T Cells #OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00467-5/fulltext

Specialized Pro-Resolving Mediators MaR1 and LXA4 Resolve Inflammation During Acute Chemical Lung Injury in the Absence of Neutrophils. From @asipath.bsky.social member Bill Muller. Full text: https://loom.ly/pCpWpvw

#LegacyContent: Programmed Death Ligand-1 in Melanoma and Extracellular Vesicles Promotes Local and Regional Immune Suppression through M2-like Macrophage Polarization. #OpenArchive: ajp.amjpathol.org/article/S000...