Osteomyelitis, a tough bone infection, often recurs despite treatment. This review highlights how biomaterials can direct immune cells to fight infections more effectively, offering hope for better therapies.😀 #Osteomyelitis #bone @brjournal.bsky.social www.nature.com/articles/s41...

Bone marrow lesions (BML) are early signs of osteoarthritis (OA). Researchers studied BML and cartilage interactions, finding that certain cells drive OA progression through inflammation and aging. This helps in developing new treatments for OA. @brjournal.bsky.social www.nature.com/articles/s41...

By studying Sirtuin 5 (Sirt5) in mice, researchers discovered a key mechanism linking mitochondrial health to bone strength, offering new hope for treating osteoporosis.👇 #Sirt5 #osteoporosis #bone @brjournal.bsky.social www.nature.com/articles/s41...

Researchers demonstrated in mice that deleting hypertrophic chondrocyte descendants impairs bone growth and healing. This revealed the cells' role in secreting factors such as thrombospondin-4, which is essential for blood vessel formation.😀 @brjournal.bsky.social www.nature.com/articles/s41...

Investigating circadian rhythm regulation, a study finds Gala-SR, a small-molecule compound, effectively restores rhythm disorders and mitigates inflammation in periodontitis, offering potential for treating inflammatory diseases.👍 #bone @brjournal.bsky.social www.nature.com/articles/s41...

Exploring the links between ossification of the posterior longitudinal ligament and endocrine-metabolic dysregulation, a review highlights potential factors and pathways, crucial for advancing early intervention and therapeutic strategies.😀 @brjournal.bsky.social www.nature.com/articles/s41...

Discogenic lower back pain is a distinct pathological entity linked to intervertebral disc degeneration. Recent review synthesizes current knowledge on its pathophysiology, risk factors, and diagnostic challenges, highlighting the need for targeted treatments.👇 #bone www.nature.com/articles/s41...

Traumatic heterotopic ossification (HO) is an abnormal bone formation after injury. A study explores how necroptotic macrophages and p21-activated kinase 4 (Pak4) influence this process, revealing potential therapeutic targets.👍 #bone #Pak4 @brjournal.bsky.social www.nature.com/articles/s41...

Osteoarthritis (OA), a common joint disorder, is a significant global healthcare challenge. This review explores how advanced materials and AI enhance OA diagnosis and treatment, offering insights for next-generation smart materials with improved performance.😀 #joint www.nature.com/articles/s41...

cPLA2, a key inflammation mediator, drives cartilage degeneration in osteoarthritis (OA) and intervertebral disc degeneration (IVDD). Inhibiting it reduces inflammation and preserves cartilage, offering hope for new therapies.👇 #osteoarthritis @brjournal.bsky.social www.nature.com/articles/s41...

A new review explores how aging affects osteoarthritis, identifying immune imbalance, cell aging, and stem cell exhaustion as key factors, guiding future treatments.👇 #osteoarthritis #cell #bone #aging @brjournal.bsky.social www.nature.com/articles/s41...

Using bone injury strategies, a recent study explores diabetic patients' foot wound healing, revealing osteokines' role in accelerating repair and offering new treatment insights.😀 #bone #diabetic #osteokines @brjournal.bsky.social www.nature.com/articles/s41...

Dendritic cells play a key role in bone repair and regeneration. New research explores their impact on bone health and potential for innovative treatments in osteoimmunology！😀 #osteoimmunology #bone @brjournal.bsky.social www.nature.com/articles/s41...

Piezo1, a key protein in bone health, boosts fracture healing by enhancing mitochondrial energy production. A new study shows it works through a pathway involving β-catenin and Lars2, offering new ways to treat fractures！👇 #Piezo1 #bone #Lars2 @brjournal.bsky.social www.nature.com/articles/s41...

According to a new study, basic fibroblast growth factor (FGF2), a key protein, regulates rRNA expression in stem cells via chromatin architecture, impacting cell fate and proliferation. These insights could enhance regenerative medicine and tissue engineering!👍 #bone www.nature.com/articles/s41...

Sarcopenia, or muscle loss in the elderly, is linked to falls, fractures, and other issues. This review explores its connection to musculoskeletal disorders and potential treatments, helping develop targeted interventions！👍 #sarcopenia #bone @brjournal.bsky.social www.nature.com/articles/s41...

Featured in Bone Research's [Top 5 Articles in the first half of 2025]😀：Bone formation and blood vessel growth are closely linked. This review explores how cells talk to each other to coordinate these processes, offering insights for bone healing and treatment！👇 www.nature.com/articles/s41...

Featured in Bone Research's [Top 5 Articles in the first half of 2025]👏：PINK1 is a protein vital for cellular health. In this research, boosting PINK1 protected joints by clearing bad mitochondria, shielding them from osteoarthritis. New hope for healthier cartilage!🥳 www.nature.com/articles/s41...

Featured in Bone Research's [Top 5 Articles in the first half of 2025]👏：Circadian rhythm genes like Bmal1 play key roles in bone and cartilage health. This review explores how Bmal1 regulates these tissues, offering insights for treating related diseases.😀 #bone #Bmal1 www.nature.com/articles/s41...

Featured in Bone Research's [Top 5 Articles in the first half of 2025] 🥳DDR2, a collagen receptor, helps bones heal better and stops abnormal bone growth, making it a promising target for improving bone health and treating related conditions.👏 @brjournal.bsky.social www.nature.com/articles/s41...

Highlight from BoneResearch! Don’t miss【Top 5 articles in the first half of 2025】Macrophages play a key role in intervertebral disc degeneration. This review provides insights into their regulatory mechanisms and potential therapeutic strategies @brjournal.bsky.social www.nature.com/articles/s41...

Schwann cells in peripheral nerves help bone healing by transforming into MSCs, which aid bone growth and blood vessel repair. This process is driven by Shh signaling. This discovery could enhance bone regeneration in aging or disease.👍 #bone @brjournal.bsky.social www.nature.com/articles/s41...

Mitochondrial dysfunction in cartilage cells drives osteoarthritis progression（OA）, but new therapies offer hope. Researchers are exploring targeted treatments to improve mitochondrial health and reduce symptoms.👇 #cartilage #mitochondrial #bone @brjournal.bsky.social www.nature.com/articles/s41...

Check out our video!👍The impact of mitochondrial dysfunction on osteoarthritis cartilage: current insights and emerging mitochondria-targeted therapies #mitochondrial #osteoarthritis #bone @brjournal.bsky.social www.nature.com/articles/s41...

This review examines the unfolded protein response (UPR) in cancer-associated bone disease, highlighting its mechanisms and potential as a target for innovative treatments, offering new directions for research.👇 #protein #cancer #bone @brjournal.bsky.social www.nature.com/articles/s41...

Osteoporosis significantly raises the risk of rotator cuff tears, with genetic links identified. Managing osteoporosis is key to prevention.👇 #bone #osteoporosis @brjournal.bsky.social www.nature.com/articles/s41...

Cover image showing pseudo-colored trabeculae of the Sost -/- proximal tibiae, highlighting how bone thickness varies, measured by µCT. This cover image was contributed by @Scott Roberts, the Royal Veterinary College, London, UK. @brjournal.bsky.social www.nature.com/articles/s41...

According to new research, the G3BP1 protein helps cancer cells evade chemotherapy. Targeting this protein could enhance treatment efficacy！👇 #G3BP1 #cancer #bone @brjournal.bsky.social www.nature.com/articles/s41...

New research shows LRP1, a key protein, is crucial for bone formation. Its deficiency can lead to severe skeletal defects. This study provides insights into bone development and related diseases.😀 #bone #skeletal @brjournal.bsky.social www.nature.com/articles/s41...

New research: Isovitexin fights bone damage! It boosts SIRT3 to protect bone cells from stress and death, improving a condition called steroid-induced osteonecrosis.👇 #bone #osteonecrosis @brjournal.bsky.social www.nature.com/articles/s41...

Vinculin: A key protein for strong bones. Loss leads to osteoporosis, but understanding it can help fight bone loss！👇 #bone #osteoporosis @brjournal.bsky.social www.nature.com/articles/s41...

Study uncovers role of protein changes in spinal disc wear. Blocking this may slow degeneration and offer new treatment path! #protein #bone @brjournal.bsky.social xn--www-e113b.nature.com/articles/s41...

FXR receptor key to bone health! Study shows it helps bone cells develop by stabilizing RUNX2 protein. FXR activator OCA can even prevent bone loss in osteoporosis mice!👍 #FXR #bone #osteoporosis @brjournal.bsky.social www.nature.com/articles/s41...

Scientists discover that cell aggregates-derived extracellular vesicles (CA-EVs) can rejuvenate aging stem cells and promote bone regeneration！ #bone #cell @brjournal.bsky.social www.nature.com/articles/s41...

New treatment for infectious bone defects combines photothermal therapy with pulsed drug delivery, enhancing precision and efficacy.😃 #bone #photothermal @brjournal.bsky.social www.nature.com/articles/s41...

Scientists reveal how increased stiffness in intervertebral discs impacts cell metabolism, identifying a key regulator in disc degeneration！👇 #cell #bone @brjournal.bsky.social www.nature.com/articles/s41...

Aptamers, tiny nucleic acid fragments, are revolutionizing bone repair and regeneration, offering precise targeting and minimal side effects!👍 #Aptamers #acid #bone @brjournal.bsky.social www.nature.com/articles/s41...

Osteogenesis imperfecta is shown to be driven by osteocyte dysfunction in new research, highlighting a specific gene mutation's impact！👇 #Osteogenesis #gene #bone @brjournal.bsky.social www.nature.com/articles/s41...

The impact of cellular senescence on skeletal diseases is outlined in new research, pointing to potential anti-aging therapies！ #skeletal #bone @brjournal.bsky.social www.nature.com/articles/s41...

Scientists use advanced cell analysis to reveal how severe injuries disrupt immune function, affecting bone healing and pointing to potential treatments！🧐 #immune #bone @brjournal.bsky.social nature.com/articles/s41...

Based on a mouse model, scientists explore how a high-fat diet causes nerve damage and weaker bones, suggesting diabetes disrupts nerve-to-bone signals and affecting bone health in type 2 diabetes!👇 #bone #diet #diabetes @brjournal.bsky.social nature.com/articles/s41...

Based on experiments in female mice, new research reveals that estrogen receptor signaling in bone cells is crucial for maintaining bone strength！🧐 #mice #bone #cell @brjournal.bsky.social nature.com/articles/s41...

The impact of rheumatoid arthritis on muscle aging is explored in new research, highlighting myopenia and sarcopenia as key factors impacting function and quality of life!👇 #muscle #myopenia #sarcopenia #bone @brjournal.bsky.social nature.com/articles/s41...

Gut health and bone strength are linked! New research shows gut microbiota can affect bone health, with potential for treating related diseases.👇 #gut #bone #microbiota @brjournal.bsky.social nature.com/articles/s41...

Understanding rheumatoid arthritis just got clearer. Recent study shows synovial fibroblasts promote cartilage damage, suggesting new treatment strategies！👇 #bone @brjournal.bsky.social nature.com/articles/s41...