Team eDyNAmiC is proposing a more holistic perspective by integrating extrachromosomal DNA (ecDNA) into the broader Hallmarks of Cancer framework. Read why in a new review published today in @cellpress.bsky.social www.cell.com/cell/fulltex...

The Hallmarks of Cancer series by Hanahan and Weinberg have been the guiding principles in how I come to understand and study cancer as a scientist. This year is the 25th anniversary of HoC since its first publication in 2020..!

We further laid out a roadmap to accelerate drug target discovery (esp. chemical proteomics approaches) and clinical deployment to actualize ecDNA-directed therapy. We hope this could be helpful for people who are interested in exploring the therapeutic space of ecDNA-driven cancers. [2/2]

I'm thrilled to start my first bluesky post by highlighting the review paper Hyerim and I have been working really hard together - published just yesterday on Nature Reviews Drug Discovery. In this review, we outlined the latest ecDNA biology and corresponding therapeutic vulnerabilities [1/2] -