#Postnatal care (PNC) plays a crucial role in averting newborn mortality, yet its use remains low, particularly in regions with the highest mortality. In this cross-sectional observational study, Hwa-Young Lee & co examine the relationship between PNC quality & utilization 🧪 #MedSky plos.io/3OUYPV5

Treatment-resistant #depression (TRD) imposes major clinical and economic burdens. In this multi-armed modelling study, Li and colleagues investigate the cost-effectiveness of Esketamine compared with six real-world third-line treatment strategies for TRD in Hong Kong 🧪 #MedSky plos.io/4tXizGm

In this self-controlled case series study, Andrew Yuen and colleagues analyze data from the United Kingdom clinical practice research datalink (CPRD) and show that gabapentinoid is associated with an increased risk of drug poisoning plos.io/42dNlyY 🧪 #MedSky

In this systematic review of publications on #HIV testing strategies, Warittha Tieosapjaroen & co find that rapid diagnostic tests have similar accuracy to lab-based tests, supporting their adoption as long-acting injectable pre-exposure prophylaxis (LAI-PrEP) is scaled up🧪 #MedSky

Circulating microbiome-related metabolites have emerged as promising biomarkers for coronary heart disease. In this Perspective, Yan Zheng & co discuss a recent multi-stage study that strengthens signal prioritization but highlights the persistent gap between association & causality🧪 plos.io/42d3ggZ

In this modeling study, Daniel De-la-Rosa-Martinez and colleagues examine in-hospital transmission of the bacterium Clostridioides difficile and the hospital’s contribution to community colonization, as well as how these are mitigated by control measures🧪 #MedSky plos.io/4tkLpkb

Tackling today’s environmental and social challenges takes more than ambition, it takes evidence. Explore open access sustainability research showing how collaboration, adaptive management and equity‑driven approaches are shaping a more resilient, sustainable future. 🔗 plos.io/4v29625

Integrating spatial #omics with #AI is likely to advance biomarker research & diagnostics. In this Editorial, Academic Editor Nic Reitsam discusses the potential & challenges of utilizing AI in the development of scalable & reproducible quantification in routine #cancer pathology 🧪

In this retrospective cohort study, Ria Garg & co evaluate how early #methadone dose titration between treatment days 4 and 6, as recommended in Canadian & US clinical guidance for individuals using #fentanyl, is associated with treatment discontinuation & opioid toxicity 🧪 #MedSky

In this cohort study, Annelise Blomberg & co investigate the association between prenatal perfluoroalkyl substances (PFAS) exposure & childhood incidence of #asthma and wheeze, finding very high prenatal #PFAS exposure was associated with higher incidence of childhood asthma 🧪

In this economic modeling analysis, Jiaying Stephanie Su and colleagues investigate the reduction in primary healthcare utilization resulting from investments to combat #HIV, #tuberculosis and #malaria during 2000–2023 in 108 low- and middle-income countries🧪 #MedSky

Abdominal obesity is a shared risk factor for dementia, functional impairment & cardiovascular disease in aging populations. This study by Yujing Zhou &co projects the 30-year burden of these conditions in Chinese adults under different trajectories of abdominal #obesity prevalence🧪 plos.io/4miRF9n

In this prospective cohort study, Hu and colleagues investigate the association between frailty and the risk of suicide attempt, and the potential mediating role of genetic risk and blood biomarkers, in UK Biobank participants🧪 #Medsky plos.io/4miPpz5

In this mathematical modelling study, Katherine Horton & co assess #TB community screening approaches & their estimated effects on TB incidence & mortality, concluding that methods that capture both infectious & non-infectious TB are needed to achieve sustained case reductions🧪 plos.io/4tuD2SM

In this systematic review & meta-analysis, Mortazavi & colleagues (@petermacp.bsky.social) investigate urban vs rural differences in #TB prevalence between 2000 and 2024 in 26 low- and middle-income countries, finding that TB epidemics have become increasingly urbanized 🧪 #MedSky plos.io/3O79BqY

In this Perspective, David Ludwig outlines why, in light of a recent lawsuit against “hyper-palatable” ultra-processed foods (UPF), a new framework centered on metabolic effects of food is required to address links between #UPF & obesity-related chronic disease🧪🍔 #MedSky #nutrition

In recognition of @who.int #WorldHealthDay 🌍, below we highlight three recent Perspectives discussing pressing challenges within #OneHealth, #globalhealth & #publichealth, exemplifying the need for innovative, international & interdisciplinary approaches to improving health around the world🧪 #MedSky

Today is #WorldHealthDay and also the One Health High-Level Summit and Global Forum of WHO Collaborating Centres. These recent articles highlight the focus on #OneHealth and “Together for health - Stand with science”: plos.io/3Qpo8yP plos.io/4skoDHR plos.io/4bWyyi0 plos.io/4cWBxHV #StandWithScience

In this systematic review and meta-analysis, Ian Ross and colleagues assess the evidence regarding the cost-effectiveness and benefit-cost of interventions promoting handwashing with soap in domestic, school or childcare settings globally 🧪 🧼 #MedSky

In meta-analysis of national and subnational #TB prevalence surveys, we found that between 2000-2024, tuberculosis epidemics are rapidly urbanising. doi.org/10.1371/jour... @plosmedicine.org @uofgshw.bsky.social @kchorton.bsky.social

In a quasi-experimental study, Pasquale Rummo and colleagues investigate the association between sugary drink taxes and calories purchased from beverages in drive-through restaurants of a fast-food chain based in the USA 🧪🧃 #MedSky plos.io/3OmZu1i

In this Perspective, Amanda Drury and colleagues outline how and why education, communication, and models of care for patients receiving oral systemic anti-cancer therapies must adapt to support safe, equitable, and sustainable treatment 🧪 #cancer #MedSky

In this randomized controlled trial, Douglas Nils Spangler & colleagues assess the potential of a machine learning–based triage tool to improve emergency triage by supporting dispatchers in identifying patients at high risk of deterioration in resource constrained situations 🧪

In this match-controlled cluster trial, Christina Vogel and colleagues assess the impact of moving the fresh fruit and vegetable section near store entrances on store-level sales, household-level purchasing and waste, and dietary behaviours 🧪🍎 #MedSky plos.io/4dpitCG

In this randomized controlled trial of adolescent girls and young women peer networks in central Kenya, Katrina Ortblad and colleagues investigate the effect of enhanced peer #PrEP referral with #HIV self-testing delivery versus standard peer referral 🧪 #MedSky plos.io/4v9ne9O

We are all set up and ready at Stand 22 for #UKSG2026! 👋 We are looking forward to meeting and discussing how we can support your institution and research community. Stop by and meet our team. @uksg.bsky.social

Long recognized as a breakthrough synthetic approach, One Health has been slow and piecemeal to infiltrate medical fields. In this Perspective, John Gittleman argues that it’s time for change by taking on a new patient - the environment 🧪🌍 #MedSky #OneHealth plos.io/4v3ljTW

After coronary stent procedures, patients take two antiplatelet medicines to reduce risk of ischemic events, but this can increase bleeding. In this meta-analysis, Navarese & co investigate the effects of early aspirin withdrawal after a percutaneous coronary intervention 🧪 #MedSky plos.io/413Mi48

In this retrospective cohort study with a target emulation trial design, Wei and colleagues investigate pain-related outcomes after methadone or buprenorphine initiation in Medicare beneficiaries treated for opioid use disorder with comorbid chronic pain 🧪 #MedSky plos.io/4s2pkFC

In this TTE study, Binh Nguyen and colleagues investigate the impact of physical activity during mid-life on mortality of Australian women later in life, finding that moderate-to-vigorous physical activity over 15 years provides protective benefits against premature mortality🧪🏃‍♀️ plos.io/47sED37

In this time-series analysis, Hong Xiao and colleagues investigate how different phases and shifts in policy stringency related to healthcare utilization in the first four years of the #COVID-19 pandemic in China 🧪 #MedSky plos.io/4bUWxwL

Building on a recent publication in @pnas.org (plos.io/4saRwae), @verokiermer.bsky.social, @magdalenaskipper.bsky.social and @kbibbinsdomingo.bsky.social call for action on adopting a principle-based approach for a responsible authorship culture 🧪 #AcademicSky @plos.org @jama.com plos.io/3Pr5ZAu

In this retrospective study, Shouqiang Zhu, Weihai Shi and colleagues developed a deep learning model for real-time prediction on intraoperative hypotension using dynamic time-series vital signs from a Chinese cohort 🧪 #MedSky plos.io/4sy6Bmd

HIV incidence among adolescent girls & young women in eastern & southern Africa has drastically declined over the past two decades. In this mathematical modeling study, Adam Akullian &co show that both biomedical #HIV interventions & broader behavioral changes contributed to declines plos.io/47WTAKN

Severe infections have been linked to increased risk of #dementia, but both conditions often coexist with other potentially confounding illnesses. In this study, Pyry Sipilä & co show that the increased dementia incidence is not attributable to these comorbid conditions 🧪 #MedSky plos.io/4lVUMUK

Conference attendance! If you're heading to the European Lung Cancer Congress in Copenhagen, keep an eye out for our Senior Editor Alex Tosun! 🧪 #ELCC26 @atosun.bsky.social

The future of the End TB response will not be decided in Washington or Geneva, but in New Delhi, Abuja, Pretoria, and Jakarta @plosmedicine.org journals.plos.org/plosmedicine...

Conference attendance! Associate Editor Katarzyna (Kasia) Starowicz is attending The Asian Conference on Aging & Gerontology 2026 in Tokyo, Japan. If you wish to discuss your research or the journal, do reach out and say hi! 🧪 #AGEN2026

In this modelling study, Elizabeth Gray & co use country-specific data on inactivated #polio vaccine schedules & coverage to estimate immunity against serotype-two poliomyelitis across 112 countries, finding that the 14-39 week immunization schedule is optimal in all countries🧪💉 plos.io/4suaTeH

Despite a lack of evidence, concerns have been expressed that #COVID-19 vaccination may lead to sudden death in younger healthy adults. In this study, Abdel-Qadir, Bhatt et al find no evidence that COVID-19 vaccines increase the risk of sudden cardiac death in young healthy adults plos.io/4bkYJP4

In this Perspective, Ann Weber & Gary Darmstadt discuss how benchmarking life expectancy against what is achievable reveals how sex disadvantage shifts by age, place, and time, and reframes inequality as unrealized potential due to social and structural constraints 🧪 #MedSky plos.io/4bjtkMX

Growing evidence links gut #microbiota to human #cardiometabolic health. In this metabolomics study, Yulu Zheng & colleagues investigate associations between microbial metabolites and coronary heart disease, performing discovery and validation analyses using five different cohorts 🧪 plos.io/4sS1TzG

Explore research‑sharing trends with our new interactive Open Science Indicators dashboard prototype. See how practices like study registration, data, code, protocol sharing and preprints vary across fields, countries, funders and organizations. 🔗 Explore #OpenScience Indicators: plos.io/3PFvT3h

In this Perspective, George Davey Smith (@mendelrandom.bsky.social) and colleagues outline how and why gene-environment equivalence, the fundamental principle of Mendelian Randomization (MR), must be properly applied and critically considered in MR studies 🧪 plos.io/3NGAxNU

Power outages threaten health when medical & communication devices lose power, particularly in vulnerable populations. In this study, Heather McBrien & colleagues investigate if power outages are associated with cardiovascular & respiratory hospitalizations in older adults in the US🧪 plos.io/4cLnS6x

In this Perspective, David Page and colleagues discuss how spatially profiling immune-tumor cell interactions using multispectral immunofluorescence analyses holds promise as a biomarker to predict outcomes in early-stage breast cancer 🧪 #breastcancer #Medsky plos.io/4s1f3dx

In this observational cohort study of women at risk of acquiring HIV, David Mukasa and colleagues report that initiating HIV preexposure prophylaxis did not associate with an increased incidence of bacterial sexually transmitted infections 🧪 #PrEP #HIV #MedSky

In this target trial emulation study, Shih-Chieh Shao and colleagues investigate the risk of hypomagnesemia in type 2 #diabetes when treated with GLP1-RAs or SGLT2 inhibitors compared to DDP4 inhibitors, using data from the TriNetX global collaborative network 🧪 #T2D #MedSky plos.io/3NsrnV8

The #COVID-19 pandemic raised concerns about diagnostic delays and treatment disruptions in childhood #cancer. Using national registry data, Kampitsi and colleagues examine patterns in childhood cancer incidence and survival before and during the COVID-19 pandemic in Sweden🧪 plos.io/40fbyUF

Global health architecture is at a structural inflection point. In this Perspective, Ebere Okereke discusses priorities for sustainable progress, including restoring country agency, strengthening national institutions & securing sustainable health financing🧪🌍 #globalhealth #MedSky plos.io/3N9RiAK