In this genome-wide association study, Richard A Armstrong and colleagues investigate the genetic architecture of postoperative delirium after major surgery and its relationship with related cognitive conditions 🧪🧠🧬 #MedSky plos.io/4lbRcW3

March is #Endometriosis Awareness Month, and this Editorial by Alex Tosun (@atosun.bsky.social) discusses why greater awareness, education, funding and research for this systemic condition is imperative to redefining pain, equity, and investment in women’s health 🧪🌻 #Medsky plos.io/4slvscE

In this pragmatic cluster non-randomized trial, Alexandra Kulinkina and colleagues investigate the effectiveness of a clinical decision support algorithm for guiding antibiotic prescribing in pediatric outpatient care in Rwanda 🧪 #MedSky #AMR #antibiotics plos.io/3MDJiIl

In recognition of Rare Disease Day, this Perspective by Tudor Groza & co discusses how AI can transform rare disease care when organized around patients, outlining a patient-clinician-AI triad spanning diagnosis, clinical trials, & individualized therapies🧪 #RareDiseaseDay

In this study, Qingyu Li and colleagues analyze data from survey responses of an e-consumer cohort in China to understand adherence to event-driven and daily HIV pre-exposure prophylaxis 🧪 #MedSky #HIV #PrEP plos.io/4cPdI4K

In this modeling study, Allison Portnoy and colleagues investigate the potential impact of reduced international donor funding on the household economic burden of tuberculosis in low- and middle-income countries 🧪 #MedSky #TB plos.io/4ryyBFX

In this observational study, Jessica Potts and colleagues investigate health inequalities associated with the transitions in kidney therapy modality or death in the UK Renal Registry 🧪 #Medsky plos.io/4aZlLe2

Conference attendance! PLOS Medicine Senior Editor Alison Farrell (@alisonfarrell.bsky.social) will be attending CROI 2026 in Denver, Colorado, next week. If you want to discuss your research, the journal, Open Access publishing, or more, do reach out and say hi! #CROI2026

Community health workers (CHWs) play a vital role in health services, but remain inadequately compensated. In this Policy Forum article, Temesgen Ayehu &co discuss healthcare reform needed in Sub-Saharan Africa to improve pay & enable integration of CHWs into civil service programs🧪

Air pollution & comorbidities such as hypertension, stroke, and depression are established risk factors for #Alzheimer’s disease (AD). In this study, Yanling Deng & co investigate whether these comorbidities mediate or amplify the effects of fine particulate matter (PM2.5) on AD 🧪🧠 plos.io/4s2zIha

What role should generative artificial intelligence (GAI) play in healthcare? In this Perspective, Arun Thirunavukarasu discusses whether #GAI should be designed to follow treatment guidelines rigidly, provide individualized recommendations, or be somewhere in between 🧪 #AI #Medsky plos.io/4tDx0jL

In this prospective cohort study, Thomas McDonnell and colleagues examine the relationship of creatinine muscle index (CMI)—an estimate of glomerular filtration of creatinine—with sarcopenia and mortality in a non-dialysis chronic kidney disease population 🧪 #MedSky #CKD plos.io/4tILvTj

In this modeling study, Natalie Carvalho and colleagues assess the cost-effectiveness of simultaneously introducing rotavirus, pneumococcal conjugate, and human papillomavirus vaccination in the Pacific Island countries Samoa, Tonga, Tuvalu and Vanuatu 🧪 #MedSky plos.io/4tEMwf9

What are the molecular mediators underlying the link between adiposity & renal cancer? Using evidence from observational & Mendelian randomization analyses, Karine Alcala & co assess obesity‑related risk factors as potential mediators in the development of renal cancer 🧪 #MedSky

In this multi-center, randomized controlled trial, Betina Durovni and colleagues assess the acceptability and safety of a short-course #tuberculosis preventive therapy taken daily or weekly for different durations by persons recently exposed to tuberculosis 🧪 #MedSky #TB plos.io/4bTs5oh

The Lancet Commission proposed an update in January 2025 on the definition of #obesity. In this observational study, David Lui and colleagues investigate the effect of this new obesity definition on the classification of individuals as overweight in two Chinese cohorts 🧪 #MedSky plos.io/4aHWg0F

Despite many antihypertensive options, uncontrolled #hypertension remains pervasive. In this Perspective, Luke Laffin & Steven Nissen discuss the promise & challenges of aldosterone synthase inhibitors as the next breakthrough treatment of uncontrolled hypertension🧪 #CVD #MedSky

In recognition of International Day of Women and Girls in STEM, this Editorial by Aparajita Chattopadhyay reflects on the gender gap in #STEM in India, outlining socio-cultural & infrastructural factors, recent promising trends, and what is needed to continue these transformations 🧪

Given recent advancements in digital technology, this systematic review and meta-analysis by Jack Le Vance and colleagues assesses whether teleultrasound is feasible, acceptable, diagnostically accurate and cost effective for antenatal care 🧪 #MedSky plos.io/4raBqgo

In this study, Cameron M. Gee and colleagues investigated whether targeting spinal cord perfusion pressure via cerebrospinal fluid drainage after acute traumatic spinal cord injury leads to better neurologic recovery than standard mean arterial pressure targets 🧪 #MedSky plos.io/4tpmoEZ

In this mathematical modeling study, Alvaro Schwalb and colleagues estimate the global burden of viable Mycobacterium tuberculosis—that which can cause disease and be transmitted—to help guide disease prevention efforts 🧪 #tuberculosis #MedSky plos.io/4aqzIQV

We are deeply saddened by the passing of Professor Sir Nicholas White. His pioneering research transformed malaria treatment worldwide, & his insight & generosity as an Academic Editor were invaluable to PLOS Medicine. Our thoughts are with his family, colleagues, & those whose lives he touched

Optimal glycemic targets for women with gestational diabetes mellitus (GDM) are unclear. In this study, Lisa Douglas & colleagues investigate the effects of different glycemic targets during pregnancy in women with GDM on the health of mothers & their children 🧪 #MedSky plos.io/4tmvh1V

Abstract deadlines are coming up for the @‌keystoneSymposia.bsky.social #CancerImmunotherapy meeting this March in Québec. Learn more about key dates and submission details: hubs.la/Q03Xlgbv0 #KSCancerImmune26

The 2022 #mpox outbreak quickly made headlines and galvanized global attention; but the #epidemic is not over. In this Perspective, Rosamund Lewis & colleagues (@who.int) highlight ongoing mpox outbreaks across Africa & the world, & advocate for a sustained global response🧪 #MedSky plos.io/45QeNFh

In this Perspective, Giulia Notini & co discuss why the rapid expansion of antibody-drug conjugates, while redefining treatment options in advanced breast #cancer, has also resulted in several unresolved challenges for sequencing strategies, trial design, & drug development programs🧪 plos.io/3Mc25dp

For #WorldCancerDay, Associate Editor Jenny Tucker discusses the people-focused theme 'United by Unique', and talks to @plosone.org Section Editor Justin Brown and @plosmedicine.org Academic Editor James Brenton about a collaborative and personalized approach. everyone.plos.org/2026/02/04/w...

It is recognized that adiposity increases liver cancer risk, but the specific biological mechanisms connecting them are not fully understood. In this study, Zhuo-Ying Li & colleagues identify metabolic mediators linking adiposity markers to liver cancer and assess potential causality plos.io/3NTHUBv

In this population-based cohort study, Rita Patel & colleagues compare socioeconomic differences of multiple outcomes among patients aged 50+ years who underwent primary total hip replacement surgery for osteoarthritis in England 🧪 #MedSky plos.io/46h0YQk

PLOS Biology is proud to present our new collection of comment and opinionated review articles on the many facets of #immunometabolism! 🧪 #immunosky #immunology #metabolism plos.io/4c5z6Cn See 🧵⬇️ for more details

Experts across microbiology, cell biology, immunology, and clinical research will unite to tackle the global TB challenge. This @‌keystoneSymposia.bsky.social meeting highlights new technologies advancing our understanding of disease from bacteria to the human host. buff.ly/1tdrFIP #KSTB26

Using Danish nationwide registry data of nearly 2 million women, Caroline H. Hemmingsen and colleagues evaluate the risk of #leukemia among pre-menopausal women using contemporary hormonal contraceptives 🧪#MedSky plos.io/4kg44Kr

In this Editorial, PLOS Medicine Editor-in-Chief Till Bärnighausen and Executive Editor Helen Lumbard outline how #climate change and associated extreme weather events are threatening human health, and call for research on the effectiveness of climate adaptation interventions🧪🌍 plos.io/4adxog2

Register now for on demand access to @keystoneSymposia.bsky.social: 'Long COVID and Other Post-Acute Infection Syndromes': hubs.la/Q03Xlbmv0 #KSLongCOVID26

This @keystoneSymposia.bsky.social conference will address topics that go beyond tumor metabolism and explore the reciprocal relationship between cancer and whole-body metabolism. Find out more and register your place: hubs.la/Q03XlgKS0 #KSTumorMetab26

In a secondary analysis of the C-STICH trial, Victoria Hodgetts Morton and colleagues investigate the association between progesterone treatment versus no treatment on #pregnancy outcomes in women at high risk of #preterm birth who had received a vaginal cervical cerclage 🧪 #MedSky

Next up in our 'meet the editors' is Academic Editor Peter MacPherson (@petermacp.bsky.social), Professor of Global Public Health and Head of Public Health at the University of Glasgow. Peter also specializes in infectious disease epidemiology, tuberculosis, HIV, and evidence synthesis 🧪 #MedSky

Deadlines are fast approaching for @keystoneSymposia.bsky.social #Neuroinflammation in Health & Disease, this June in Whistler! See scholarship, abstract and discount registration dates: hubs.la/Q03XljQv0 #KSNeuroInflam26

In this study, Daiki Tatematsu et al apply an "energy landscape analysis", which models multivariate psychological states as a dynamic system of interactions, to evaluate longitudinal changes in psychological distress among high school students before & during the COVID-19 pandemic🧪🧠 plos.io/4bjzrBk

Explore emerging research with field leaders @keystoneSymposia.bsky.social #CancerImmunotherapy: Mechanisms, Clinical Advances & Combinations, this March in Québec! hubs.la/Q03Xlgbv0 #KSCancerImmune26

Our Section Editor Rubeena Zakar and coauthor Sarosh Iqbal give an Overview of @plos.org's Collection on Health Literacy, which is key to enhancing healthcare access, improving health outcomes and reducing health disparities. journals.plos.org/plosone/arti... collections.plos.org/collection/h...

Next in our 'meet the editors' is Associate Editor, Suzanne de Bruijn. Suzanne handles papers in cardiovascular disease, diabetes & endocrinology, and maternal & child health. She will be attending the upcoming Keystone cardiometabolism conference next week, so do reach out if you'll be there!🧪⬇️

Next in our 'meet the editors' is Professor Madhukar Pai (@madhupai.bsky.social), Canada Research Chair in Epidemiology & Global Health & inaugural Chair of the Department of Global & Public Health at McGill University. Areas of expertise include TB, global and public health, & infectious diseases🧪

Anti-amyloid drugs modestly slow #Alzheimer’s disease progression, but also paradoxically accelerate brain volume changes. In this Perspective, Francesca Alves and Scott Ayton examine potential explanations and argue for transparent release of clinical trial data🧪 #MedSky plos.io/49TRdsv

In this study, Ayaka Monoi and colleagues model the benefits and risks of maternal respiratory syncytial virus (RSV) vaccination by gestational age and show that benefits outweigh risks with vaccination from the third trimester 🧪💉 #Medsky #vaccines #RSV plos.io/4bEBIXO

Next up in our 'meet the editors' is our Senior Editor, Alex Tosun ( @atosun.bsky.social). Alex handles papers in the areas of cancer, rheumatology and musculoskeletal disease, and global health 🧪 #Medsky #PLOSMedicine

GLP-1-based medications for obesity have seen unprecedented rises in popularity. However, as outlined by Ariana Chao & co in this Perspective, this rapid growth is met with rising concerns about side effects, long-term outcomes & predatory marketing practices🧪 #GLP-1 #obesity #Medsky plos.io/4qAXy2U

PLOS Ecosystems is our new open access journal bringing together rigorous research across terrestrial, freshwater, and marine systems - linking biodiversity, ecosystem function, and nature’s contributions to people. ➡️ Help shape the future of ecosystems research: plos.io/4puYlRE

Explore cutting‑edge science at keystonesymposia.bsky.social with the upcoming meeting “Antibodies as Drugs: Engineering and Computational Tools Enabling Clinical Advances.” Co‑located with “Emerging Cell Therapies”. Find out more: hubs.la/Q03XlfWC0

In this retrospective analysis of whole-slide images from individuals with stage II colorectal cancer used to train a deep learning model, Zihan Zhao and colleagues identify histological features associated with risk of disease recurrence. 🧪 #Medsky #CRC #cancer plos.io/4qpIzJi