Organoid photo and inspiration for the Cover of @stemcellreports.bsky.social July issue - many thanks to the team that made APOE4's starry night the cover! 🟢 Tuj1 (beta III tubulin for neurons, 🔵 DAPI for DNA 🔴 My favorite protein, APOE

My talented undergrad student, Adyasha Aruk showing off her cryomolds from organoids she cut (each mold is 1-2 hours). I might make it into a trophy 👀

Excited to share my first author publication exploring the neurodevelopmental role of APOE4. Using organoids, we show that APOE4 shifts the balance between neurogenesis and gliogenesis, accelerates maturation, and alters network function. Lasty, cortical APOE4 was sufficient to alter function.

Can't believe I'm graduating with my PhD in Neuro in 10 days. I loved my dissertation project, studying the neurodevelopmental impact of APOE, and the implications on Alzheimer's. Starting over from Twitter, please help me meet more neuro enthusiasts that love research in Alz, glia, and APOE!

My second science card for my husband (also PhD), interested in aging research. Fun fact, naked mole rates like like 27 years, the longest relative life span to most rodent species. Anyone know why?

Making science cards for my favorite scientists 🤓 C. Elegans for my advisor

My NIH funded fellowship has allowed me to investigate how the leading Alzheimer's disease genetic risk factor, APOE4, shapes the developing human brain. 1 in 4 people are APOE4 carriers, and my research suggests that early changes in the brain may lead to later brain vulnerability.

APOE4 increases energy metabolism in APOE-isogenic iPSC-derived neurons https://www.biorxiv.org/content/10.1101/2024.06.03.597106v1