@tomsextonlab.bsky.social
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pinned post!
Out now in @ScienceAdvances 👇
science.org/doi/10.1126/...
A great team effort, spearheaded by Angeliki, showing that promoter and enhancer dynamics become homogenized on transcriptional activation, and that loop extrusion and transcription compete to put brakes on chromatin
loading . . .
Transcription processes compete with loop extrusion to homogenize promoter and enhancer dynamics
Gene promoters and enhancers share the same constrained mobilities during transcription, opposing cohesin-mediated loop extrusion.
https://science.org/doi/10.1126/sciadv.adq0987
11 months ago
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The perfect addition to our Christmas tree: an ES cell and a cancer cell, knitted by the super talented @cathieerb
11 months ago
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From 2023: out now in
@plosbiology.org
👇 TLDR: Transcription CAN directly remodel TADs... in specific contexts. Big congrats to Sanjay and @yousra_zouari who spearheaded the project, and @djost_physbiol +Hossein
11 months ago
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We've now joined BlueSky - we'll try and catch up with all the Twitter/X expats asap
11 months ago
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Out now in @ScienceAdvances 👇
science.org/doi/10.1126/...
A great team effort, spearheaded by Angeliki, showing that promoter and enhancer dynamics become homogenized on transcriptional activation, and that loop extrusion and transcription compete to put brakes on chromatin
loading . . .
Transcription processes compete with loop extrusion to homogenize promoter and enhancer dynamics
Gene promoters and enhancers share the same constrained mobilities during transcription, opposing cohesin-mediated loop extrusion.
https://science.org/doi/10.1126/sciadv.adq0987
11 months ago
2
20
2
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