Shrijan Bhattarai (@rainshj.bsky.social)

In this new paper we find that Tel1 kinase (yeast ATM) targets D/E-S/T motifs… more prevalent than S/T-Q! Mec1 (yeast ATR) can’t target D/E-S/T, so we think D/E-S/T targeting allows Tel1 functional specialization. A mutation in Tel1 makes it only target S/T-Q… and cells become CPT sensitive.

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Profiling Tel1 Signaling Reveals a Non-Canonical Motif Targeting DNA Repair and Telomere Control Machineries The stability of the genome relies on Phosphatidyl Inositol 3-Kinase-related Kinases (PIKKs) that sense DNA damage and trigger elaborate downstream si… https://www.sciencedirect.com/science/article/pii/S0021925825000419?via%3Dihub