Debashis Dhara
@debashisdhara.bsky.social
📤 17
đź“Ą 20
đź“ť 3
Postdoc, University of Oxford
Glad to share our new paper online! Splice-switching oligonucleotides and click conjugates containing LNA-phosphothiotriester linkages
academic.oup.com/nar/article/...
#RNAtherapeutics
#Oligonucleotides
#SpliceSwitching
#Phosphorothioate
#NucleicAcids
loading . . .
Biophysical and biological properties of splice-switching oligonucleotides and click conjugates containing LNA-phosphothiotriester linkages
Abstract. Antisense oligonucleotides hold great promise in the treatment of disease, but their efficacy is limited by modest bioavailability and toxicity.
https://academic.oup.com/nar/article/53/21/gkaf1263/8340990
2 months ago
0
1
0
Charge neutral oligonucleotides
onlinelibrary.wiley.com/doi/full/10....
loading . . .
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.202511386
4 months ago
0
0
0
reposted by
Debashis Dhara
Chemical Society Reviews
11 months ago
This review is from
@hollensteinlab.bsky.social
,
@debashisdhara.bsky.social
and Laurence Mulard at
@pasteur.fr
'Natural, modified and conjugated carbohydrates in nucleic acids'
#OpenAccess
🔓
pubs.rsc.org/en/content/a...
loading . . .
Natural, modified and conjugated carbohydrates in nucleic acids
Storage of genetic information in DNA occurs through a unique ordering of canonical base pairs. However, this would not be possible in the absence of the sugar–phosphate backbone which is essential fo...
https://pubs.rsc.org/en/content/articlelanding/2025/cs/d4cs00799a
1
10
6
Happy to share our latest review article on carbohydrates in nucleic acids!
@chemsocrev.bsky.social
pubs.rsc.org/en/content/a...
loading . . .
Natural, modified and conjugated carbohydrates in nucleic acids
Storage of genetic information in DNA occurs through a unique ordering of canonical base pairs. However, this would not be possible in the absence of the sugar–phosphate backbone which is essential fo...
https://pubs.rsc.org/en/content/articlelanding/2025/cs/d4cs00799a#ChemSocRev
12 months ago
0
3
1
you reached the end!!
feeds!
log in
