(@jeanjuchung.bsky.social)

Starting first posting in Bluesky! In this study, we delineate CatSper’s assembly order and molecularly define a binding surface for activity modulation, offering CatSper canopies as potential targets for fertility control. www.biorxiv.org/content/10.1...

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CATSPERϵ extracellular domains are essential for sperm calcium channel assembly and activity modulation The sperm flagellar-specific CatSper Ca2+ channel is a multiprotein complex critical for successful fertilization. The four ancillary subunits, CATSPERβ, γ, δ, and ε, form a unique canopy structure ov... https://www.biorxiv.org/content/10.1101/2024.11.18.624146v2