Jahn Zhong
@jahnzhong.bsky.social
📤 20
📥 21
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reposted by
Jahn Zhong
Greifflab
12 months ago
We created one of the largest antibody bottom-up proteomics datasets to query the impact of experimental and computational parameters on the reconstruction of antibody sequences.
www.biorxiv.org/content/10.1...
Brilliant work by
@mchernigovskaya.bsky.social
, Khang Le Quy and Igor Snapkow.
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Systematic benchmarking of mass spectrometry-based antibody sequencing reveals methodological biases
The circulating antibody repertoire is crucial for immune protection, holding significant immunological and biotechnological value. While bottom-up mass spectrometry (MS) is the most widely used prote...
https://www.biorxiv.org/content/10.1101/2024.11.11.622451v1
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reposted by
Jahn Zhong
Diego del Alamo
over 1 year ago
Someone got the covid vaccination 217 times (two hundred and seventeen, or appx one every five days) and "did not report any vaccination-related side effects" and "showed no abnormalities attributable to hypervaccination" 🧪🧬🧶
www.thelancet.com/journals/lan...
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Adaptive immune responses are larger and functionally preserved in a hypervaccinated individual
Prime-boost vaccinations can enhance immune responses,1 whereas chronic antigen exposure can cause immune tolerance.2 In humans, the benefits, limitations, and risks of repetitive vaccination remain p...
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00134-8/fulltext
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reposted by
Jahn Zhong
Eva Smorodina
about 2 years ago
Our work on antibody developability is out! We present a cartography of the developability landscapes of native and human-engineered antibodies. This study was a team effort of Habib Bashour,
@evasmorodina.bsky.social
, Matteo Pariset, and
@jahnzhong.bsky.social
from
@victorgreiff.bsky.social
, UiO
add a skeleton here at some point
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