@alexgutierrezd.bsky.social
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Nephrology at Hospital Miguel Servet, Zaragoza, Spain, and biophilia everywhere
Great news and a highly anticipated article. Not a word about the immunosuppression received??? Just a mention in supplemental material (standard steroid-free IS, islet transplantation protocol by the Clinical Islet Transplantation Consortium).
www.nejm.org/doi/full/10....
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Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM
Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimisle...
https://www.nejm.org/doi/full/10.1056/NEJMoa2506549?query=TOC&cid=DM2415341_Non_Subscriber&bid=-1178067420#supplementary-materials
3 months ago
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Very interesting article about the different preferences and perceptions of older patients regarding their health and increasing age. Health Outcome Preferences and Trade-Offs Among Older Adults With Advanced CKD - American Journal of Kidney Diseases
www.ajkd.org/article/S027...
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Health Outcome Preferences and Trade-Offs Among Older Adults With Advanced CKD: A Discrete Choice Experiment
Decision making for the treatment of kidney failure in older adults, should incorporate patient preferences. This discrete choice experiment (DCE) aimed to identify the health outcome preferences of o...
https://www.ajkd.org/article/S0272-6386%2825%2900967-9/fulltext
4 months ago
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Beatiful review of basic cellular and molecular mechanisms for sensing imbalances in blood osmolality, volume, and sodium content The neurobiology of thirst and salt appetite: Neuron
www.cell.com/neuron/fullt...
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The neurobiology of thirst and salt appetite
Thirst and salt appetite are critical for maintaining fluid balance. In this review, Grove and Knight discuss how fluid imbalances are sensed at a molecular level and how these signals converge on bra...
https://www.cell.com/neuron/fulltext/S0896-6273%2824%2900799-2
4 months ago
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Transplantation is a story of serendipity, of lives intertwined in ways both seen and unseen. The Serendipitous Dance between Life and Death | New England Journal of Medicine
www.nejm.org/doi/full/10....
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The Serendipitous Dance between Life and Death | NEJM
As her father awaits an organ for his third transplantation, a surgical resident retrieves a kidney from a fellow hockey fan, recognizing at a deep, personal level the value of his gift of life.
https://www.nejm.org/doi/full/10.1056/NEJMp2502925?query=TOC&cid=DM2412190_Non_Subscriber&bid=-1213828634
4 months ago
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A necessary wake-up call about an everyday reality in all kidney transplant programs Unmet Educational and Psychosocial Support Needs After Graft Loss: A Call for Clarity and Compassion.
journals.lww.com/transplantjo...
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Unmet Educational and Psychosocial Support Needs After... : Transplantation
An abstract is unavailable.
https://journals.lww.com/transplantjournal/fulltext/2025/08000/unmet_educational_and_psychosocial_support_needs.14.aspx
4 months ago
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An impressive leap forward in the field of transplantation. I'm eagerly awaiting a whole organ modification.
@senefrologia.bsky.social
@edoardomelilli.bsky.social
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | New England Journal of Medicine
www.nejm.org/doi/full/10....
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Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | NEJM
The need to suppress a patient’s immune system after the transplantation of allogeneic cells is associated with wide-ranging side effects. We report the outcomes of transplantation of genetically m...
https://www.nejm.org/doi/full/10.1056/NEJMoa2503822?query=TOC&cid=DM2411188_Non_Subscriber&bid=-1224984383
4 months ago
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Clear, direct, understandable, i love it
www.youtube.com/watch?v=NukU...
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Human Papillomavirus and Cancer | NEJM
YouTube video by NEJM Group
https://www.youtube.com/watch?v=NukU5pdLvzw
4 months ago
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reposted by
Maria José Pérez Sáez
5 months ago
Aquí os dejamos una pincelada del proyecto COMPARTE-TR Súmate!
@senefrologia.bsky.social
@auxiliadoramaz2.bsky.social
@pepasolerr.bsky.social
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reposted by
Maria José Pérez Sáez
6 months ago
Happy to share our collaborative work in Spain highlighting frailty prevalence among KT candidates
#frailty
#kidneytransplant
url7417.frontierspartnerships.org/ls/click?upn...
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Frontiers Publishing Partnerships | Frailty Prevalence and Characterization Among Kidney Transplant Candidates in Spain: A Multicenter Study
Frailty is a frequent condition among kidney transplant candidates (KTc) that confers poor outcomes after transplantation. We aimed to establish frailty prev...
https://url7417.frontierspartnerships.org/ls/click?upn=u001.pU5iRCWmQrGyDrAYnepT6B9qS3zMeeoDsTGgXWsQ7ivvCJefIHcbuLbuyoj9IF0C1Z-2BDxCM2IUCLmjd4r-2FOcVOy9eoDf5oKlpIECvjtJ-2BG0-3Dp_XT_kc5UvQt18VqLF-2BkdwUgAJSYZxCkP-2B4fRFjIAWhmAYl9XBKuC8gQ32NzmEN4Nyy8MY01AVc6mfvEba83mLSXXJADS2gOls4DMi2sh5OdGafdR882H6M5izyUweWL7dS12QdkKjOkfN0oGZqaYb7jktWBFCbCZutaXFla309iJDBlI6VEA98hYIFz0XgSyfPqOI8YoqCEAD2ELfHBddF7QmyEWSRcFnamYfio-2BIl-2B2F-2FYHbTDzIbbdR4li6S4YoWBwPknqHG9-2FO1NawtYitKCGobYDWSp-2Byjn6HPzZDNX082KFs7H8XewX6Y-2Bv2ZxdbBUlOIYSoqY7YrLhKHQVSEK2IaYg71ZWaep-2FJvZdLCzrDKLK1bonplZYS4niyBmrwHmI
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looking forward to seeing it, I'm afraid it won't be a fiction film but rather a story of everyday reality...
www.theguardian.com/film/2025/ju...
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The shocking hit film about overworked nurses that’s causing alarm across Europe
A Swiss film about a nurse pushed to her limits one night is being praised for the picture it paints of treacherously underfunded healthcare. The director talks about the ‘heart-pounding’ story that i...
https://www.theguardian.com/film/2025/jul/29/late-shift-swiss-hospital-nurses-overworked-healthcare?CMP=Share_AndroidApp_Other
4 months ago
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youtube.com/post/Ugkxi3X...
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Post from The Guardian - YouTube
Gaza: ‘Clean it out then bring in something good’ ► https://youtu.be/43oZ0yUDG8E “No one knows what will come to replace the international system that is cur...
http://youtube.com/post/Ugkxi3X4ZhMEH9UP-EhJd4G8c_VpLvGzkuRh?si=eXYqJjR8DBGr6EuQ
5 months ago
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reposted by
Sociedad Española de Nefrología
6 months ago
¿Quieres formar parte de una nueva edición del
#CursoTXMir2025
#TrasplanteEnAcción
? 🫵🫵¡ABRIMOS INSCRIPCIONES!
senefro.org/modules.php?...
Curso dirigido a socios MIR4 que quieran formarse en Trasplante Renal 👏
@alexgutierrezd.bsky.social
@martacrespo.bsky.social
@mjoseperezsaez.bsky.social
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Fantástica iniciativa de nuestra compañeras del equipo de Nefrología del Hospital San Juan de Dios
@senefrologia.bsky.social
7 months ago
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reposted by
Nephrology Journal Club
7 months ago
Major Trials in the use of ASIs targeting difficult-to-control hypertension
#NephJC
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"... a fundamental change in the ethical framework of the law will be difficult to reverse, and the unintended harms to altruism and transplantation as a noncommercial process ... are likely to be irreversible"
@senefrologia.bsky.social
@edoardomelilli.bsky.social
jamanetwork.com/journals/jam...
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The End Kidney Deaths Act Risks Irreversible Harm to Organ Donation
This Viewpoint explores the possible negative effects of the End Kidney Deaths Act on organ donation and transplant and offers strategies on how to narrow the gap between organ demand and supply.
https://jamanetwork.com/journals/jama/fullarticle/2832002?utm_source=twitter&utm_campaign=content-shareicons&utm_content=article_engagement&utm_medium=social&utm_term=052225
7 months ago
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Really interesting "the common clinical practice of using the phenotype antigen beads as a screening assay, reflexing to SAB testing only when positive, may inadvertently fail to detect DQ-specific antibodies"
www.sciencedirect.com/science/arti...
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Antigen quantity is responsible for the discrepancy between phenotype and single antigen beads for the detection of HLA-DQ antibody: potential clinical implications
De novo donor-specific HLA-DQ antibodies detected by single antigen beads (SAB) are significantly associated with chronic antibody-mediated rejection …
https://www.sciencedirect.com/science/article/pii/S1600613525002011?dgcid=raven_sd_aip_email#fig5
8 months ago
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8 months ago
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Uau!!! wise words "Kidney transplantation is a health and lifespan-extending procedure that relies on the expertise of transplant nephrologists" 💪👏👏
@senefrologia.bsky.social
@edoardomelilli.bsky.social
www.sciencedirect.com/science/arti...
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THE ECONOMIC VALUE OF A TRANSPLANT NEPHROLOGIST: THE CASE FOR IMPROVING COMPENSATION MODELS
This article examines the economic value of transplant nephrologists and the need for adequate compensation. Kidney transplantation is a health and li…
https://www.sciencedirect.com/science/article/abs/pii/S1600613525001406?dgcid=raven_sd_aip_email
9 months ago
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Excellent work and an essential guide 👍. With the changes in our population of kidney transplant recipients, the urgent need to improve the evaluation and treatment of frailty is becoming more evident every day.
@senefrologia.bsky.social
@mjoseperezsaez.bsky.social
journals.lww.com/transplantjo...
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Unmet Questions About Frailty in Kidney Transplant... : Transplantation
tion with transplant outcomes. Being prefrail significantly impacts both graft and patient survival, often beginning with just 1 Fried criterion. Rather than viewing frailty as a categorical state, it...
https://journals.lww.com/transplantjournal/abstract/2025/02000/unmet_questions_about_frailty_in_kidney_transplant.16.aspx
11 months ago
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x.com/supermariajo...
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x.com
https://x.com/supermariajo/status/1882055506598252799?t=llzjYhw23zpg5DiwElhH1Q&s=09
11 months ago
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reposted by
Héctor Uroz
11 months ago
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Asymptomatic BP elevations in the hospital are commonly treated with as-needed BP medications, and this could be associated with increased AKI risk.
jamanetwork.com/journals/jam...
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One-Time and As-Needed Blood Pressure Medication and Adverse Outcomes in VA Hospitals
This cohort study evaluates the risk for acute kidney injury and other adverse effects from as-needed and 1-time blood pressure medications in hospitalized veterans.
https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2826330
11 months ago
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reposted by
American Journal of Kidney Diseases
11 months ago
Check out the best of the best on the
#AJKDBlog
: Top Ten AJKDBlog Posts of 2024!
https://bit.ly/3WyYnwz
(FREE)
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A paradigm shift? This interesting article shows a complex relationship between GFR, NT-proBNP and CV risk in patients with HF-pEF and CKD, and call into question proposals for higher NT-proBNP references ranges in people with CKD.
@senefrologia.bsky.social
www.jacc.org/doi/10.1016/...
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Natriuretic Peptides, Kidney Function, and Clinical Outcomes in Heart Failure With Preserved Ejection Fraction:
https://www.jacc.org/doi/10.1016/j.jchf.2024.08.009?utm_medium=email_newsletter&utm_source=jchf&utm_campaign=toc&utm_content=20250107&s=03
11 months ago
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reposted by
ISNkidneycare
11 months ago
📖 This weekend don't miss our @kidneyint.bsky.social #ISNFridaySelection: Targeted gene therapy for rare genetic kidney diseases
www.kidney-internati...
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When the top 1% of people hold as much wealth as the bottom 90%, as in the US today, is it time to take drastic action? Limiting the accumulation of wealth would make societies better overall How rich is too rich?
www.nature.com/articles/d41...
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How rich is too rich?
Where should society draw the line on extreme wealth? A fresh account sets out the logic and suggests how to redress inequality.
https://www.nature.com/articles/d41586-024-01276-1
11 months ago
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#stopgenocide
As Hopes Rise for Gaza Cease-Fire, Conditions There Have Worsened
www.nytimes.com/2024/12/28/w...
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What to Know About Gaza’s Humanitarian Crisis Amid Cease-Fire Push
Human rights organizations and residents describe the situation in the enclave as getting more desperate. Here is a closer look.
https://www.nytimes.com/2024/12/28/world/middleeast/gaza-cease-fire-human-rights.html?smid=nytcore-android-share
12 months ago
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Sufficient staffing at dialysis centers associated with access to waiting lists and kidney transplants in older adults (Patzer RE, AJT 2014), young, and adolescents
@senefrologia.bsky.social
@SETrasplante
@mjoseperezsaez.bsky.social
@ONT_esp
#acerca
jamanetwork.com/journals/jam...
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Dialysis Facility Staffing Ratios and Kidney Transplant Access Among Adolescents and Young Adults
This cohort study aims to determine whether patient to nurse or patient to social worker staff ratios are associated with access to kidney transplant for adolescents and young adults.
https://jamanetwork.com/journals/jama/fullarticle/2825311?utm_source=twitter&utm_campaign=content-shareicons&utm_content=article_engagement&utm_medium=social&utm_term=121824
12 months ago
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x.com/SETrasplante...
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x.com
https://x.com/SETrasplante/status/1868582632680013857?t=FFzcgeXjR9ZygbK3ipXqkg&s=09
12 months ago
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Another opportunity for improvement. Bisphosphonates are underused in kidney transplant patients and may be associated with additional benefits beyond bone health. @SENTRA @SET
journals.lww.com/cjasn/abstra...
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Bisphosphonate Use After Kidney Transplantation Is... : Clinical Journal of the American Society of Nephrology
bisphosphonates associates with lower incidence of non-vertebral fractures after kidney transplantation. Methods: We conducted a retrospective review for all Southern California Kaiser Permanente k...
https://journals.lww.com/cjasn/abstract/9900/bisphosphonate_use_after_kidney_transplantation_is.496.aspx
about 1 year ago
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Effect of Delayed Remote Ischemic Preconditioning on Acute Kidney Injury and Outcomes in Patients Undergoing Cardiac Surgery: A RCT | Circulation. New hope for overcoming the limitations of previous evidence in kidney tx (Ko E, et al. Syst Rev. 2024;(1):201)
www.ahajournals.org/doi/10.1161/...
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Effect of Delayed Remote Ischemic Preconditioning on Acute Kidney Injury and Outcomes in Patients Undergoing Cardiac Surgery: A Randomized Clinical Trial | Circulation
BACKGROUND: Remote ischemic preconditioning (RIPC) has 2 time windows for organ protection: acute and delayed. Previous studies have mainly focused on the organoprotective effects of acute RIPC. We ai...
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.124.071408
about 1 year ago
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reposted by
ISNkidneycare
about 1 year ago
𝗧𝗢𝗗𝗔𝗬: ISN webinar: "How GLP1 receptor agonist evolved from weight management drugs to kidney protective therapy?". 🗣️ Katherine Tuttle, Peter Rossing 👤 Sola Bahous 🗓️ December 3 🕕 5 pm CET 🔗 Free registration:
ow.ly/XoCg50UcV94
#NephSky
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"the association between physical activity and mortality risk remained consistent across the adult lifespan, which contrasts with other modifiable health factors, for which associations with mortality risk diminished with age" more than a pill
jamanetwork.com/journals/jam...
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https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2826554?guestAccessKey=bdd088aa-4d7c-4e41-9151-2a6db460f230&utm_source=silverchair&utm_medium=email&utm_campaign=jama_network&utm_content=network_highlights&utm_term=November%2027,%202024&adv=000002221988
about 1 year ago
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Interesting for kidney transplant recipients. GLP-1RAs vs insulin were associated with a great risk reduction in 10/13 obesity-associated cancers in T2D, but showed no risk reduction versus metformin. Could there be a synergistic effect of the combination?
jamanetwork.com/journals/jam...
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GLP-1RAs and Obesity-Associated Cancers in Patients With Type 2 Diabetes
This cohort study evaluates whether glucagon-like peptide receptor agonists (GLP-1RAs) are associated with risk of obesity-associated cancer among patients with type 2 diabetes compared with insulin o...
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2820833?utm_source=twitter&utm_campaign=content-shareicons&utm_content=article_engagement&utm_medium=social&utm_term=120124
about 1 year ago
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Amazing Engage II ESOT meeting in Barcelona, plenty of ideas and exchange of experiences in an evolving field @SENTRA @SEN @ESOT
about 1 year ago
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Adding ezetimibe to moderate-intensity statins could be a better approach to reach target LDL-C levels with less new-onset diabetes and intolerance than high high-intensity statin strategy. I think that is true for all statin doses in renal transplant recipients
jamanetwork.com/journals/jam...
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LDL Cholesterol–Lowering Strategy in ASCVD
This systematic review and individual patient data meta-analysis investigates the association of an alternative low-density lipoprotein (LDL) strategy with differences in long-term efficacy and safety...
https://jamanetwork.com/journals/jamacardiology/fullarticle/2826516?guestAccessKey=379a36bd-9cb9-4d98-a5e4-0c67cc5dc007&utm_source=silverchair&utm_medium=email&utm_campaign=jama_network&utm_content=network_highlights&utm_term=112424&adv=000002221988
about 1 year ago
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We still have room for research in kidney tx recipients. Among hospitalized patients with bloodstream infection, antibiotic treatment for 7 days was noninferior to treatment for 14 days BUT PATIENTS WITH SEVERE IMMUNOSUPPRESSION WERE EXCLUDED
www.nejm.org/doi/full/10....
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Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections | NEJM
Bloodstream infections are associated with substantial morbidity and mortality. Early, appropriate antibiotic therapy is important, but the duration of treatment is uncertain. In a multicenter, non...
https://www.nejm.org/doi/full/10.1056/NEJMoa2404991?query=TOC&cid=DM2372811_Non_Subscriber&bid=-1640152947
about 1 year ago
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Slow correction (<8 or 6-10 mEq/L per 24 hours) and very slow correction (<4-6 mEq/L per 24 hours) of severe hyponatremia were associated with an increased risk of mortality and hospital LOS compared to rapid correction (≥8-10 mEq/L per 24 hours)
jamanetwork.com/journals/jam...
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Correction Rates and Clinical Outcomes in Hospitalized Adults With Severe Hyponatremia
This systematic review and meta-analysis evaluates the association of sodium correction rates with mortality among hospitalized adults with severe hyponatremia.
https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2826087
about 1 year ago
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