Quantitative Biosciences Institute, UCSF
@qbi-ucsf.bsky.social
📤 70
📥 14
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Transforming our understanding of biology and disease through collaborative, quantitative research.
We’re welcoming Kevin Lou as a QBI Fellow! In his Q&A, he shares what inspired his journey into chemical biology, why QBI is the right place to pursue his vision, and how quantitative approaches are shaping the future of drug discovery. Read more:
qbi.ucsf.edu/kevin-lou-qb...
18 days ago
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APOE4, the strongest genetic risk for Alzheimer’s, disrupts the recycling centers of nerve cells, laying the foundation for toxic protein accumulation. A new study led by Einar Krogsaeter & Danielle Swaney sheds light on early cellular stress in AD. Read more:
www.tandfonline.com/doi/full/10....
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Lysosomal proteomics reveals mechanisms of neuronal APOE4-associated lysosomal dysfunction
APOE4 is the primary risk factor for Alzheimer disease (AD). Early AD pathological events first affect the neuronal endolysosomal system, which in turn causes neuronal protein aggregation and cell ...
https://www.tandfonline.com/doi/full/10.1080/15548627.2025.2576613?src=#abstract
about 1 month ago
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What happens when a chromosome breaks & how do cells put it back together? Jim Haber
@brandeisuniversity.bsky.social
will be at UCSF next week to share how scientists learned to watch DNA repair in real time & what that reveals about how cells maintain genetic stability.
qbi.ucsf.edu/seminar-haber
about 1 month ago
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Join us on November 13 for a seminar with Dr. Rafael Couñago of UNC on leveraging AI models to accelerate chemical probe discovery for Target 2035! Learn more & register for his talk:
qbi.ucsf.edu/seminar-coun...
about 1 month ago
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How does AI meet molecular structure to reveal the roots of health & disease? Join us for a QBI seminar with Dr. Arun Prasad Pandurangan of University of Cambridge on November 12 at UCSF Mission Bay! Learn more & register:
qbi.ucsf.edu/seminar-pand...
about 1 month ago
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How do cells control what enters and exits the nucleus? A study maps the nuclear pore complex in unprecedented detail, solving a decades-old mystery and offering insights into cancer, Alzheimer’s, and ALS:
www.pnas.org/doi/10.1073/...
about 2 months ago
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We look forward to welcoming Dr.
@andykilianski.bsky.social
, Program Manager at ARPA-H for a seminar hosted by James Fraser. Learn about how ARPA-H is investing in bold, transformative research to shape the future of health in the United States:
qbi.ucsf.edu/seminar-kili...
about 2 months ago
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AI is powering new frontiers in drug discovery, but success still depends on good data and biological insight. This
@cenmag.bsky.social
piece features our director, Nevan Krogan, among voices exploring the real promise and pitfalls of AI in biomedicine.
cen.acs.org/physical-che...
about 2 months ago
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Join us for the next Infectious Diseases & Human Health Mini-Symposium by
@gladstoneinst.bsky.social
and QBI: “Viral Landscapes: How to Comprehensively Monitor Evolutionary Trajectories" on 9/23. Learn more & register:
qbi.ucsf.edu/givi-mini-sy...
3 months ago
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New QCRG-AViDD study: SARS-CoV protein Orf9b shape-shifts to block our immune defenses by binding to mitochondria’s Tom70. Lipids & mutations tweak how efficiently it works -revealing new insights into coronavirus immune evasion. Learn more:
doi.org/10.7554/eLif...
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Coupled equilibria of dimerization and lipid binding modulate SARS Cov 2 Orf9b interactions and interferon response
Lipid binding stabilizes the SARS-CoV-2 Orf9b homodimer, slowing its conversion to the Tom70-binding monomeric form and modulating interferon suppression.
https://doi.org/10.7554/eLife.106484.3
3 months ago
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The HARC Center supports scientists through Mentored Scientist and Collaborative Developmental Awards, fostering HIV research and training opportunities. Check out this year’s awardees and the projects they’re working on! 🔬✨https://bit.ly/HARCawards2025
3 months ago
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In this QBI TV Fireside Chat, Amber Smith sits down with Zelda Love to share insights from her team’s new cryo-EM structure of the HIV-1 Rev/RRE/CRM1/Ran complex. Watch the episode & read the study:
qbi.ucsf.edu/Smith-Love-Q...
3 months ago
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Speaker lineup announced & registration now open! Join us for a chance to connect, celebrate, and support the next generation of researchers at the QBI Internship Symposium on 8/19.
qbi.ucsf.edu/qbi-intern-s...
4 months ago
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We look forward to hosting Dr. Ludovic Deriano of Institut Pasteur
@pasteur.fr
next week at UCSF on August 5! He’ll share how BRCA1/2-deficient cells adapt to DNA damage and how CRISPR screens reveal new targets for cancer therapy. Learn more & save your spot:
qbi.ucsf.edu/seminar-deri...
4 months ago
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QBI-UCSF launches the Paul Farmer African Initiative for Research (PFAIR) to strengthen research capacity across Africa by building a foundation for sustainable research through mentorship, funding, and international exchange for African scientists. Learn more:
www.ucsf.edu/news/2025/07...
4 months ago
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We look forward to having Dr. Andy Kilianski of ARPA-H at QBI for a seminar! Join us to learn how ARPA-H is investing in bold, high-impact research to transform the future of health in the U.S. Learn more & register:
qbi.ucsf.edu/seminar-kili...
5 months ago
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We’ve enjoyed having Hoai Nguyen as a visiting scholar this summer! Join us July 14 as she wraps up her time at QBI and
@gladstoneinst.bsky.social
with a seminar on her team’s CRISPR-based dengue virus diagnostic assay.
qbi.ucsf.edu/seminar-hoai...
#GlobalHealth
#CRISPR
#Dengue
5 months ago
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Dari Kimanius (
@czbiohub.bsky.social
) is joining us at UCSF
@ucsanfrancisco.bsky.social
for next week’s AI in Biology symposium! He’ll share how ML is advancing in situ Cryo-ET and how foundation models are enabling high-throughput discovery. See full speaker lineup:
qbi.ucsf.edu/ai-symposium...
6 months ago
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Longtime collaborators Steven Altschuler & Lani Wu will share how AI helps map cell phenotypes for early drug discovery, while stressing the need for biological validation. Hear them at “AI in Biology” @UCSF, June 17–18.
qbi.ucsf.edu/ai-symposium...
#QBI
#AIinBiology
#UCSF
#BiotechInnovation
6 months ago
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Next week at UCSF: Brian Cheung of MIT will share how large language models can grasp the real world, even without seeing or hearing a thing! Catch him at the QBI/Rezo “AI in Biology” symposium June 17–18. Few tickets left:
qbi.ucsf.edu/ai-symposium...
#QBI
#AIinBiology
#UCSF
#BiotechInnovation
6 months ago
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Meet Cecilia Clementi, Physics Prof at
@freieuniversitaet.bsky.social
+ speaker at the QBI/Rezo “AI in Biology” symposium next week! Join us June 17–18 at UCSF
@ucsanfrancisco.bsky.social
:
qbi.ucsf.edu/ai-symposium...
#QBI
#Rezo
#AIinBiology
#UCSF
#BiotechInnovation
6 months ago
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Meet Anil Palepu, Research Scientist at Google and speaker at our QBI/Rezo Therapeutics “AI in Biology” symposium on June 17-18! Register to join:
qbi.ucsf.edu/ai-symposium...
#SpeakerSpotlight
#QBI
#AIinBiology
#RezoTherapeutics
#ScienceSymposium
#BiotechInnovation
#ai
6 months ago
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Meet Angela Oliveira Pisco, Head of Computational Biology at inistro
@insitro.bsky.social
and speaker at our QBI/Rezo “AI in Biology” symposium on June 17-18! Register to join:
qbi.ucsf.edu/ai-symposium...
#SpeakerSpotlight
#QBI
#AIinBiology
#RezoTherapeutics
#ScienceSymposium
#BiotechInnovation
6 months ago
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Join us June 17–18 at UCSF for “Separating the Signal from the Noise: AI in Biology” — a 2-day symposium with speakers from Google, Genentech, Insitro, MIT, Freie Universität Berlin, CZI, University of Toronto, Alberta Machine Intelligence Institute, QBI UCSF, and Rezo!
qbi.ucsf.edu/ai-symposium...
7 months ago
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From AI-driven discoveries to building collaborative ecosystems, QBI Director Nevan Krogan shares his vision for the future of science-and why Berlin is an exceptional partner in that mission. Read the full Q&A via
@einsteinberlin.bsky.social
:
www.einsteinfoundation.de/en/questionn...
7 months ago
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QBI & Thermo Fisher are hosting a Lunch & Learn on May 9 at UCSF! Learn how to set up robust quantitative proteomics experiments using cutting-edge mass spectrometry with insights from Kevin Yang & Rafael Melani. Lunch included! Learn more & register:
qbi.ucsf.edu/qbi-thermo-f...
7 months ago
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QBI Director Nevan Krogan was awarded an Einstein Visiting Fellowship with Christian Freund at Freie Universitat Berlin. Now, their labs use mass spec, cryo-EM & computational tools to study epilepsy & influenza A—catalyzing a long-term partnership.
pharmacy.ucsf.edu/news/2025/04...
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Bridging borders in science: Q&A with Einstein Visiting Fellow Nevan Krogan, PhD
April 23, 2025 · The Department of Bioengineering and Therapeutic Sciences professor will lead a new global research initiative with Freie Universität Berlin, establishing a Berlin-based lab to advanc...
https://pharmacy.ucsf.edu/news/2025/04/bridging-borders-science-qa-einstein-visiting-fellow-nevan-krogan-phd
8 months ago
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Join us April 24 at QBI for a seminar with Dr. Hoai Nguyen, who will share her work in infectious disease research and explore opportunities for international collaboration in diagnostics, antimicrobial resistance, and global health. Learn more & register:
qbi.ucsf.edu/seminar-hoai...
8 months ago
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Yesterday’s Structural Biology & Proteomics Workshop, co-sponsored by the Host Pathogen Map Initiative & HARC Centers, featured expert talks, lab tours, and hands-on learning. Thanks to all who joined us for a day of science and collaboration!
#StructuralBiology
#Proteomics
8 months ago
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Curious about launching a startup or navigating a path to extend the reach of your research? Join us for the Innovation Ventures Startup Workshop, led by the UCSF Office of Technology Management and tailored for the QBI community and faculty!
qbi.ucsf.edu/startup-work...
8 months ago
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Join us for the Structural Biology & Proteomics Training Workshop on 4/15! This hands-on event offers researchers a chance to explore techniques in structural biology and proteomics. Learn more & register:
qbi.ucsf.edu/structuralbi...
9 months ago
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This week QBI and
@institutpasteur.bsky.social
celebrated their scientific alliance–launched in 2019 & now expanded as the Pasteur-UCSF-Gladstone Center
@gladstoneinst.bsky.social
.
www.pasteur.fr/en/research-...
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An international scientific alliance to strengthen the fight against infectious diseases
The Institut Pasteur and UCSF-QBI celebrated an ongoing successful scientific collaboration today, which was initiated in March 2019, and expanded significantly during the pandemic. This alliance, for...
https://www.pasteur.fr/en/research-journal/news/international-scientific-alliance-strengthen-fight-against-infectious-diseases
9 months ago
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QBI presents the 3rd Full Circle of Native & Indigenous Scientists in Biology symposium on April 3-4, 2025 at UCSF Mission Bay. A gathering of Native scientists across career stages, focused on community & representation in academia. Join us!
qbi.ucsf.edu/full-circle-...
9 months ago
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That's a wrap on the QBI Hackathon! Thank you to everyone who joined for a weekend of innovation, collaboration, and problem-solving. So many inspiring ideas and great exchanges. Congrats to all the teams for your hard work and creativity!
qbi.ucsf.edu/hackathon2025
9 months ago
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In honor of
#InternationalWomensDay
, we're sharing a series of fireside chats with trailblazing women from our global network of collaborators. Tune in to hear their journeys, challenges, and achievements—an inspiration for future game changers!
youtube.com/playlist?lis...
9 months ago
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UCSF scientists are leading the “avoid-ome” project to equip AI with data to spot drug development pitfalls. Their ADME data library aims to enhance AI models for faster, more efficient drug discovery. Learn more:
nature.com/articles/d41...
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Four ways to power-up AI for drug discovery
Insights from artificial intelligence could eventually transform drug development, if the quality and quantity of biological and chemical data can be improved.
https://nature.com/articles/d41586-025-00602-5
9 months ago
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Starting soon! Don’t miss today’s QBI seminar with Ewa Bomba-Warczak, Assistant Professor at UPenn Perelman School of Medicine, hosted by Nevan Krogan. See you at 11 AM in Mission Bay!
qbi.ucsf.edu/seminar-warczak
9 months ago
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Mark your calendar for February 28! Join us for a talk by Yury Polikanov, hosted by Danica Fujimori, on how ribosome-targeting antibiotics work—and how bacteria fight back. Learn more & register:
qbi.ucsf.edu/seminar-poli...
10 months ago
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Thanks to everyone who joined our pre-hackathon mixer last night. It was great to see new connections forming! The main event is just 2 weeks away! Bay Area developers and scientists will team up to tackle biomedical challenges! Sign up now!
#LetsCollaborate
qbi.ucsf.edu/qbi-hackatho...
10 months ago
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Join us on Feb 27 for a seminar with Dr. Janina Sörmann on deep learning’s role in designing modulators for acid-sensing ion channels—a promising yet underexplored stroke therapy target! Learn more & register:
qbi.ucsf.edu/qbi.ucsf.edu...
10 months ago
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Are you a life scientist with imaging or mass spec data but no coding skills? Or a computer scientist eager to apply AI & ML to biomedical challenges? Join the QBI Hackathon—a 48-hour event uniting Bay Area devs & scientists to push science forward!
qbi.ucsf.edu/qbi-hackatho...
10 months ago
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In honor of
#InternationalDayofWomenandGirlsinScience
, we are celebrating some of the incredible women who help drive our success! This year’s theme,
#RedefiningSuccess
, highlights how accomplishments can take many forms. Check it out!
qbi.ucsf.edu/womeninscien...
10 months ago
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Thinking about moving from academia to industry? Join us on Feb 7 for a seminar with Dr. Ron Aoyama of Gilead Sciences. With 20+ years in biotech, he'll share tips on making the leap, building skills, and positioning yourself for success. Learn more:
qbi.ucsf.edu/seminar-aoyama
11 months ago
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Excited to announce the Infectious Insights Webinar Series in collaboration with
@institutpasteur.bsky.social
&
@gladstoneinst.bsky.social
! Kicking off Feb 5, at 9 AM PST | 6 PM CET, the first session tackles the Mpox outbreak, a global health challenge. Learn more:
qbi.ucsf.edu/infectious-i...
11 months ago
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